INT74505

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.10
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 1
lung 1
cortex 1
PGE2 1
DRN 1
Inadl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 219 100.00 Very High Very High Very High
gABA 10 100.00 Very High Very High Very High
dopamine receptor 9 100.00 Very High Very High Very High
agonist 41 99.98 Very High Very High Very High
c fibre 9 98.72 Very High Very High Very High
nMDA receptor 4 98.66 Very High Very High Very High
Eae 7 98.56 Very High Very High Very High
adenocard 3 98.04 Very High Very High Very High
tramadol 3 97.96 Very High Very High Very High
lidocaine 5 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 4 99.20 Very High Very High Very High
Hypersensitivity 3 98.40 Very High Very High Very High
Hypertension 9 98.20 Very High Very High Very High
INFLAMMATION 3 96.92 Very High Very High Very High
Hypercapnia 3 96.68 Very High Very High Very High
Disease 29 93.84 High High
Natriuresis 2 93.40 High High
Schizophrenia 27 92.80 High High
Diuresis 2 92.76 High High
Increased Venous Pressure Under Development 1 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats.
Positive_regulation (Activation) of D2-like associated with c fibre, dopamine and hypersensitivity
1) Confidence 0.35 Published 2003 Journal Am. J. Respir. Crit. Care Med. Section Title Doc Link 12531778 Disease Relevance 0.19 Pain Relevance 0.62
This study was performed to determine whether activation of dopamine D2-like receptors inhibits the hyperresponsiveness of pulmonary C fibers induced by inflammatory mediators such as prostaglandin E2 (PGE2).
Spec (whether) Positive_regulation (activation) of D2-like in PGE2 associated with inflammatory mediators and dopamine
2) Confidence 0.35 Published 2003 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12531778 Disease Relevance 0.17 Pain Relevance 0.47
In conclusion, these results clearly show that activation of the dopamine D2-like receptors attenuates the hyperresponsiveness of pulmonary C fibers to both chemical stimuli and lung inflation.
Positive_regulation (activation) of D2-like in lung associated with dopamine
3) Confidence 0.35 Published 2003 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12531778 Disease Relevance 0.22 Pain Relevance 0.58
These data suggest that dopamine agonists increase the release of GABA in the prefrontal cortex through a D2-like receptor.
Positive_regulation (increase) of D2-like in cortex associated with gaba, dopamine and agonist
4) Confidence 0.24 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9536031 Disease Relevance 0.09 Pain Relevance 0.99
These results indicate that DA-induced membrane depolarization in DRN 5-HT neurons is mediated by the activation of D2-like DA receptors.
Positive_regulation (activation) of D2-like in DRN associated with dopamine
5) Confidence 0.18 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488956 Disease Relevance 0 Pain Relevance 0.92
Administration of lidocaine into the VH also potentiated the increase in locomotor activity induced by D1-like receptor activation, but decreased that produced by co-activation of D1-like and D2-like receptors in the NAcc core.
Positive_regulation (co-activation) of D2-like associated with eae and lidocaine
6) Confidence 0.16 Published 2007 Journal Hippocampus Section Abstract Doc Link 17604350 Disease Relevance 0 Pain Relevance 0.86
Stimulation of dopamine D2-like receptors decreases extracellular dopamine in the dorsal striatum and the nucleus accumbens.
Positive_regulation (Stimulation) of D2-like in nucleus accumbens associated with nucleus accumbens and dopamine
7) Confidence 0.13 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12144934 Disease Relevance 0 Pain Relevance 0.43
The above results suggest that dopamine at low concentrations acts preferentially on D1-like receptors to promote N-methyl-D-aspartate receptor-mediated transmission, while at high concentrations dopamine also activates D2-like receptors, leading to a suppression of the N-methyl-D-aspartate function.
Positive_regulation (activates) of D2-like associated with dopamine and nmda receptor
8) Confidence 0.08 Published 1999 Journal Neuroscience Section Abstract Doc Link 10366010 Disease Relevance 0 Pain Relevance 0.81
Chronic treatment with tetrodotoxin reduced the number of fluorescent clusters of both D1-like and D2-like receptors, while chronic treatment with a high concentration of potassium increased the number of fluorescent clusters of both D1-like and D2-like receptors.
Positive_regulation (increased) of D2-like associated with tetrodotoxin
9) Confidence 0.08 Published 2000 Journal Neuroreport Section Abstract Doc Link 10976947 Disease Relevance 0.08 Pain Relevance 0.13
Apomorphine, which stimulates D1-like and D2-like dopamine receptors, induces detrusor overactivity in rats.
Positive_regulation (stimulates) of D2-like associated with tramadol, dopamine receptor and overactive bladder
10) Confidence 0.06 Published 2003 Journal J. Urol. Section Abstract Doc Link 12796703 Disease Relevance 0.37 Pain Relevance 0.57
A remarkable feature of dopamine functioning is that the concomitant activation of D1-like and D2-like receptors acts to intensify the expression of various dopamine-dependent effects, in particular the expression of the immediate-early genes, c-fos and zif268.
Positive_regulation (activation) of D2-like associated with dopamine
11) Confidence 0.04 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10103090 Disease Relevance 0 Pain Relevance 0.25
The prevailing opinion is that D2-like receptor function is upregulated in SHRs [43, 51, 71].
Positive_regulation (upregulated) of D2-like
12) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.90 Pain Relevance 0.54
A relative smaller pulsatile dopamine surge in response to a salient stimulus would therefore result in less activation of postsynaptic dopamine D1 and D2-like receptors, eventually resulting in reduced psychomotor activity in response to the stimulus.
Positive_regulation (activation) of D2-like associated with dopamine
13) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.08 Pain Relevance 0.65

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