INT74506

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 1.95
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 12
livers 2
neurons 1
nociceptors 1
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 29 100.00 Very High Very High Very High
nociceptor 7 99.52 Very High Very High Very High
imagery 18 97.66 Very High Very High Very High
substance P 5 96.92 Very High Very High Very High
Inflammation 27 94.76 High High
Paracetamol 26 94.68 High High
agonist 21 86.80 High High
Acute pain 9 86.76 High High
Dorsal horn neuron 1 79.52 Quite High
Glutamate 2 78.32 Quite High
Disease Link Frequency Relevance Heat
Pain 35 100.00 Very High Very High Very High
Neurogenic Inflammation 1 94.76 High High
Necrosis 13 94.72 High High
Infection 2 68.04 Quite High
INFLAMMATION 21 67.52 Quite High
Inflammatory Bowel Disease 32 66.24 Quite High
Disease 10 55.68 Quite High
Cancer 18 54.64 Quite High
Repression 4 52.32 Quite High
Nociception 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that coactivator PBP is essential for nuclear translocation of CAR but not PRIP.
Localization (translocation) of CAR in CAR
1) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.06 Pain Relevance 0.13
These results establish that transcription coactivator PBP plays a pivotal role in nuclear localization of CAR, that it is likely that PBP either enhances nuclear import or nuclear retention of CAR in hepatocytes, and that PRIP is redundant for CAR function.
Localization (localization) of CAR in CAR
2) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.09 Pain Relevance 0.18
CAR is localized to the hepatocyte cytoplasm but to be functional, it translocates into the nucleus in the presence of phenobarbital-like CAR ligands.
Localization (translocates) of CAR in CAR
3) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0 Pain Relevance 0
CAR translocation into the nucleus of PRIP null livers resulted in the induction of CAR target genes such as CYP2B10, necessary for the conversion of acetaminophen to its hepatotoxic intermediate metabolite, N-acetyl-p-benzoquinone imine.
Localization (translocation) of CAR in livers associated with paracetamol
4) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.07 Pain Relevance 0.17
Using this approach we investigated the role of transcription coactivators PBP and PRIP in the translocation of EGFP-CAR into the nucleus of PBP and PRIP liver conditional null mouse hepatocytes.
Localization (translocation) of EGFP-CAR in CAR
5) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0 Pain Relevance 0.06
Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro.
Localization (translocation) of CAR in livers
6) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.07 Pain Relevance 0.15
These results establish that transcription coactivator PBP plays a pivotal role in nuclear localization of CAR, that it is likely that PBP either enhances nuclear import or nuclear retention of CAR in hepatocytes, and that PRIP is redundant for CAR function.
Localization (retention) of CAR in CAR
7) Confidence 0.71 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.09 Pain Relevance 0.17
These results establish that transcription coactivator PBP plays a pivotal role in nuclear localization of CAR, that it is likely that PBP either enhances nuclear import or nuclear retention of CAR in hepatocytes, and that PRIP is redundant for CAR function.
Localization (retention) of CAR in CAR
8) Confidence 0.71 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.09 Pain Relevance 0.17
Using this approach we investigated the role of transcription coactivators PBP and PRIP in the translocation of EGFP-CAR into the nucleus of PBP and PRIP liver conditional null mouse hepatocytes.
Localization (translocation) of EGFP-CAR in CAR
9) Confidence 0.71 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0 Pain Relevance 0.06
These results establish that transcription coactivator PBP plays a pivotal role in nuclear localization of CAR, that it is likely that PBP either enhances nuclear import or nuclear retention of CAR in hepatocytes, and that PRIP is redundant for CAR function.
Localization (localization) of CAR in CAR
10) Confidence 0.67 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.09 Pain Relevance 0.18
We now demonstrate that adenovirally driven EGFP-CAR, as expected, translocates into the nucleus of normal wild-type hepatocytes following phenobarbital treatment under both in vivo and in vitro conditions.
Localization (translocates) of EGFP-CAR in CAR
11) Confidence 0.66 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0 Pain Relevance 0
We now demonstrate that adenovirally driven EGFP-CAR, as expected, translocates into the nucleus of normal wild-type hepatocytes following phenobarbital treatment under both in vivo and in vitro conditions.
Localization (translocates) of EGFP-CAR in CAR
12) Confidence 0.62 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0 Pain Relevance 0
Consistent with these results, chromatin immunoprecipitation experiments revealed that ASC-2 is recruited to the known CAR target genes in a ligand-dependent manner.
Localization (recruited) of CAR in CAR
13) Confidence 0.62 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.05 Pain Relevance 0.08
B and other nuclear receptors, since RXR is a common partner for many nuclear receptors including CAR, VDR, RAR, TR, LXR and PPARs [Xie and Tian, 2006].
Localization (receptors) of CAR in CAR
14) Confidence 0.17 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.49 Pain Relevance 0.13
We conclude that the release of tachykinins from primary afferent pain-sensing receptors (nociceptors) is required to produce moderate to intense pain.
Localization (release) of pain-sensing in nociceptors associated with pain and nociceptor
15) Confidence 0.12 Published 1998 Journal Nature Section Abstract Doc Link 9537322 Disease Relevance 0.61 Pain Relevance 1.18
To assay large numbers of neurons simultaneously, we used ratiometric calcium imaging which detects global changes in cytoplasmic calcium levels and assesses both direct (e.g., modulation of a putative calcium-permeable NO receptor) and indirect (e.g., release of calcium from intracellular stores and/or downstream activation of calcium-permeable ion channels) processes.
Localization (release) of calcium-permeable NO receptor in neurons associated with imagery
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0.22 Pain Relevance 0.39

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