INT74520

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 31.68
Pain Relevance 7.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD68) plasma membrane (CD68)
Anatomy Link Frequency
macrophages 9
neuron 3
adipose tissue 2
limb 2
dendritic cells 1
CD68 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 6 99.80 Very High Very High Very High
Inflammation 289 99.72 Very High Very High Very High
Inflammatory response 19 99.66 Very High Very High Very High
rheumatoid arthritis 171 99.50 Very High Very High Very High
spastic colon 369 99.16 Very High Very High Very High
cytokine 73 96.20 Very High Very High Very High
epidural 1 88.56 High High
Pain 89 88.40 High High
backache 1 85.44 High High
Infliximab 23 84.12 Quite High
Disease Link Frequency Relevance Heat
Cancer 165 99.78 Very High Very High Very High
INFLAMMATION 321 99.72 Very High Very High Very High
Rheumatoid Arthritis 230 99.50 Very High Very High Very High
Obesity 345 99.46 Very High Very High Very High
Neuroma 49 99.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

440 99.16 Very High Very High Very High
Injury 103 98.98 Very High Very High Very High
Asthma 8 98.92 Very High Very High Very High
Rhinitis 27 98.48 Very High Very High Very High
Histiocytic Sarcoma 99 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining revealed that the tumor cells were positive for CD21, CD23, CD35, and clusterin, and focally positive for CD68, CD20, and CD79a.
Positive_regulation (positive) of CD68 associated with cancer
1) Confidence 0.61 Published 2006 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17076538 Disease Relevance 0.50 Pain Relevance 0.13
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Positive_regulation (upregulated) of CD68 in dendritic cells
2) Confidence 0.60 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
Cachectic patients were not insulin resistant, and neither upregulation of proinflammatory CD68, TNF-?
Neg (neither) Positive_regulation (upregulation) of CD68
3) Confidence 0.58 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.60 Pain Relevance 0.12
Our study extends this observation further and suggests that adipose tissue inflammation reflected by increases in CD68 and TNF-?
Positive_regulation (increases) of CD68 in adipose tissue associated with inflammation and obesity
4) Confidence 0.58 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.74 Pain Relevance 0.11
There were interstitial and perivascular aggregates of foamy histiocytes which were positive for CD-68 immunostaining.
Positive_regulation (positive) of CD-68 in histiocytes
5) Confidence 0.49 Published 1998 Journal J. Korean Med. Sci. Section Abstract Doc Link 9539328 Disease Relevance 0.85 Pain Relevance 0.15
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Positive_regulation (positive) of CD 68 in neuron
6) Confidence 0.45 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.89 Pain Relevance 0.08
The tumour cells were immunohistochemically characterized by positive staining for vimentin confirming its mesenchymal origin, and CD68 consistent with histiocyte-like qualities (Fig. 1E, F).
Positive_regulation (staining) of CD68 in histiocyte associated with cancer
7) Confidence 0.44 Published 2004 Journal Acta Neurochir (Wien) Section Abstract Doc Link 15057539 Disease Relevance 0.92 Pain Relevance 0.24
Immunohistochemical staining showed tumor cells with positive results for vimentin and CD68.
Positive_regulation (results) of CD68 associated with cancer
8) Confidence 0.43 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.85 Pain Relevance 0.07
Contrary to our expectations, adipose tissue expressions of proapoptotic and inflammatory markers were not increased in cachectic patients, and CD68 or TNF-?
Neg (not) Positive_regulation (increased) of CD68 in adipose tissue associated with inflammatory marker and obesity
9) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.90 Pain Relevance 0.30
A time course analysis of injury duration (time elapsed between the injury and the removal of the neuroma) demonstrated an immediate increase in CD68-IR, which remained above control levels during the entirety of the time course (Figure 7).
Positive_regulation (increase) of CD68 associated with injury and neuroma
10) Confidence 0.40 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 1.02 Pain Relevance 0.20
The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.
Positive_regulation (positive) of CD68 in spindle cells
11) Confidence 0.40 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.85 Pain Relevance 0.21
Mononuclear cells expressing CD4 (helper T cells) and CD68 (macrophages) also were significantly increased in the duodenal mucosa of asthma and rhinitis compared with controls.
Positive_regulation (increased) of CD68 in macrophages associated with asthma and rhinitis
12) Confidence 0.39 Published 2004 Journal Allergy Asthma Proc Section Abstract Doc Link 15510586 Disease Relevance 1.63 Pain Relevance 0.25
The latter consistently expresses S-100 protein, ATPase and HLA-DR, and is variably, weakly positive for CD68, lysozyme, and CD45 [1,5-8].
Positive_regulation (positive) of CD68
13) Confidence 0.34 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.09 Pain Relevance 0
They were strongly positive for CD163 (Fig. 4), CD68, lysozyme, NSE, and vimentin.
Positive_regulation (positive) of CD68
14) Confidence 0.34 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.33 Pain Relevance 0
Immunohistochemical staining in the tumor cells was positive for CD163, CD68, lysozyme, CD45, and NSE.
Positive_regulation (positive) of CD68 associated with cancer
15) Confidence 0.34 Published 2007 Journal Diagn Pathol Section Abstract Doc Link PMC1808440 Disease Relevance 0.86 Pain Relevance 0
Immunohistochemistry is variable, but in most cases, staining is positive for CD68, CD4, CD45, HLA-DR, and lysozyme, but negative for S100, CD20, and factor XIIIa [7].
Positive_regulation (positive) of CD68
16) Confidence 0.33 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.05 Pain Relevance 0.10
Multinucleated CD68-positive cells localized at the bone surface (insets) resembled osteoclasts.
Positive_regulation (Multinucleated) of CD68 in osteoclasts
17) Confidence 0.32 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.64 Pain Relevance 0.03
In the normal non-RA intima, macrophages are positive for CD68 and fibroblasts are negative, making it more certain that macrophages express CXCR5 in this cell layer [45].
Positive_regulation (positive) of CD68 in macrophages associated with rheumatoid arthritis
18) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.07 Pain Relevance 0.50
CD68 immunoreactivity (CD68-IR) was significantly increased in human limb neuromas (8.96 ± 0.99; n = 12; p < 0.0001) compared to the control group (0.32 ± 0.04; n = 13).
Positive_regulation (increased) of CD68 in limb associated with neuroma
19) Confidence 0.29 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.82 Pain Relevance 0.16
The molecular regulators of EP1 expression in DRG neurons are unknown – trauma and initial inflammatory response (shown by rapid increases of CD68-IR) may lead to increased EP1 levels, to which PGs may contribute.
Positive_regulation (increases) of CD68 in neurons associated with inflammatory response and injury
20) Confidence 0.29 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.90 Pain Relevance 0.68

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