INT74527

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Context Info
Confidence 0.38
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 13.31
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
platelet 3
brain 2
stromal cells 1
pancreas 1
oligodendrocytes 1
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 103 98.48 Very High Very High Very High
Inflammation 75 96.88 Very High Very High Very High
antagonist 16 96.28 Very High Very High Very High
chemokine 57 96.00 Very High Very High Very High
fibrosis 144 94.88 High High
Chronic pancreatitis 5 93.84 High High
Kappa opioid receptor 8 91.72 High High
isoflurane 2 87.12 High High
anesthesia 2 86.24 High High
opioid receptor 1 86.00 High High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 18 100.00 Very High Very High Very High
Anaplastic Astrocytoma 16 100.00 Very High Very High Very High
Fibrosis 159 99.96 Very High Very High Very High
Pancreatitis 6 99.32 Very High Very High Very High
Meningioma 8 97.80 Very High Very High Very High
Myocardial Infarction 41 97.76 Very High Very High Very High
Hepatitis B Virus Infection 10 97.56 Very High Very High Very High
Pathologic Processes 16 97.36 Very High Very High Very High
Cancer 356 97.24 Very High Very High Very High
Hepatitis C Virus Infection 72 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, there was a significant increase in the mRNA levels of type beta PDGF receptor in the pancreatitis samples by comparison with the normal pancreas (P < 0.001).
Positive_regulation (increase) of PDGF in pancreas associated with pancreatitis
1) Confidence 0.38 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.73 Pain Relevance 0.40
Similarly, autocrine loops involving PDGF-A or -B and their respective receptors was also observed in many malignant and low-grade astrocytomas, while the activation of PDGF autocrine loops was suggested to be an early event in the pathogenesis of malignant astrocytomas [33].
Positive_regulation (activation) of PDGF associated with anaplastic astrocytoma and malignant neoplastic disease
2) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 2.17 Pain Relevance 0.12
Autocrine activation of PDGF was observed and interpreted as an important mechanism involved in brain and other tumors.
Positive_regulation (activation) of PDGF in brain associated with cancer
3) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC1780053 Disease Relevance 0.65 Pain Relevance 0.04
In order to investigate the effect of PDGF release rate on PDGF biological function in vivo, nine groups of 3 animals each were prepared to test in a rat wound healing model. [24] They were grouped as follows:
Spec (investigate) Positive_regulation (rate) of PDGF associated with wound healing
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.10 Pain Relevance 0.13
Quantitative Real-time PCR confirmation of PDGF-BB induction
Positive_regulation (induction) of PDGF-BB
5) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.13
On the one hand, treatment with imatinib/gleevec disrupted an autocrine PDGF/PDGFR loop by specifically inhibiting phosphorylation of PDGFR and thus exerted a synergistic antitumoral effect with ionising radiation as radiosensitizer [54].
Positive_regulation (autocrine) of PDGF
6) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.15 Pain Relevance 0.09
Similarly, autocrine loops involving PDGF-A or -B and their respective receptors was also observed in many malignant and low-grade astrocytomas, while the activation of PDGF autocrine loops was suggested to be an early event in the pathogenesis of malignant astrocytomas [33].
Positive_regulation (activation) of PDGF associated with anaplastic astrocytoma and malignant neoplastic disease
7) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 2.24 Pain Relevance 0.13
A schematic diagram depicts the suggested role of radiation induced PDGF signaling in fibrogenesis (Fig. 1).


Positive_regulation (induced) of PDGF associated with fibrosis
8) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.55 Pain Relevance 0.17
However, radiation of stromal cells, such as fibroblasts and endothelial cells, induced paracrine PDGF in co-culture systems which substantially stimulated the proliferation of non-irradiated fibroblasts [51].
Positive_regulation (induced) of PDGF in stromal cells
9) Confidence 0.25 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.80 Pain Relevance 0.19
Many investigators have shown that autocrine activation of PDGF was interpreted to be an important pathogenetic mechanism involved in different brain tumors [16-18].
Positive_regulation (activation) of PDGF in brain associated with brain tumor
10) Confidence 0.25 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.78 Pain Relevance 0.03
PDGF in radiotherapy-induced fibrogenesis
Positive_regulation (induced) of PDGF associated with fibrosis
11) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.18 Pain Relevance 0.17
Intramyocardial transplantation of EPC after AMI induces significant and sustained increase in angiogenic, antiapoptotic, and chemoattractant factors, that are upregulated in both transplanted and host cells (i.e., vascular endothelial growth factor-A [VEGF-A], fibroblast growth factor-2 [FGF-2], angiopoietin-1 [Ang-1], angiopoietin-2 [Ang-2], placenta growth factor [PIGF], hepatocyte growth factor [HGF], insulin-like growth factor-1 [IGF-1], platelet-derived growth factor-B [PDGF-B], and stromal cell-derived factor-1 [SDF-1]) [35].
Positive_regulation (upregulated) of platelet-derived growth factor-B in platelet associated with myocardial infarction
12) Confidence 0.19 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.62 Pain Relevance 0.33
ROS play also an important role in fibrogenesis throughout increasing platelet-derived growth factor [56] or the secretion of profibrotic cytokines, such as TGF-?.
Positive_regulation (increasing) of platelet-derived growth factor in platelet associated with fibrosis and cytokine
13) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.64 Pain Relevance 0.20
Validation of the platelet gel comprised measurement of the growth factors platelet-derived growth factor AB (PDGF AB) and epidermal growth factor (EGF), as well as the thrombocyte and leukocyte counts.
Positive_regulation (measurement) of PDGF AB in platelet
14) Confidence 0.03 Published 2008 Journal J Extra Corpor Technol Section Abstract Doc Link 18853833 Disease Relevance 0.62 Pain Relevance 0
In oligodendrocytes, it also decreased with cAMP, but increased under the effect of bFGF and PDGF-BB.
Positive_regulation (increased) of PDGF-BB in oligodendrocytes
15) Confidence 0.01 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.08 Pain Relevance 0.40

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