INT74528

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.34
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
endothelial cell 1
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 18 100.00 Very High Very High Very High
chemokine 27 99.00 Very High Very High Very High
Chronic pancreatitis 5 98.54 Very High Very High Very High
cytokine 83 88.60 High High
fibrosis 153 88.08 High High
Glutamate 2 77.28 Quite High
Inflammation 57 69.32 Quite High
Inflammatory response 9 60.32 Quite High
dexamethasone 9 59.56 Quite High
cINOD 9 33.80 Quite Low
Disease Link Frequency Relevance Heat
Cancer 379 99.84 Very High Very High Very High
Desmoid Disease 36 99.70 Very High Very High Very High
Meningioma 9 99.24 Very High Very High Very High
Leukemia 9 99.00 Very High Very High Very High
Pancreatitis 6 98.54 Very High Very High Very High
Fibrosis 172 97.96 Very High Very High Very High
Gastrointestinal Stromal Tumor 18 97.64 Very High Very High Very High
Neuroblastoma 9 92.20 High High
Brain Tumor 36 91.48 High High
Recurrence 9 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In chronic pancreatitis, PDGF A chain mRNA transcripts were also abundant, and 11 of 19 samples exhibited the PDGF B chain mRNA transcript.
Negative_regulation (exhibited) of PDGF associated with chronic pancreatitis
1) Confidence 0.40 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.73 Pain Relevance 0.39
PDGF inhibition in combination with radiotherapy
Negative_regulation (inhibition) of PDGF
2) Confidence 0.31 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.64 Pain Relevance 0
Thus, inhibition of PDGF may be an attractive therapy option, alone or combined with surgery or/and radiotherapy in refractory cases.
Negative_regulation (inhibition) of PDGF
3) Confidence 0.31 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.50 Pain Relevance 0.03
A sustained release of PDGF not only influences tissue neogenesis and neovascularization, but also impacts the PDGF-induced gene profile of chemokine family members, actin, and interleukins.
Negative_regulation (impacts) of PDGF associated with chemokine
4) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.35
Todo et al showed DNA synthesis in tumor cells could be inhibited through an antagonist of PDGF in three of seven meningiomas cell lines [32].
Negative_regulation (antagonist) of PDGF associated with meningioma, cancer and antagonist
5) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.92 Pain Relevance 0.13
Suppression of PDGF is discussed as one potential mechanism of action of some novel antifibrotic drugs undergoing clinical trials [88,89].
Negative_regulation (Suppression) of PDGF
6) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.47 Pain Relevance 0.21
Recently it has been shown that three distinct receptor tyrosine kinase inhibitors (RTKI), overlapping in inhibition of PDGF signaling, attenuated radiation-induced pulmonary fibrogenesis in vivo [78].
Negative_regulation (inhibition) of PDGF associated with fibrosis
7) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.93 Pain Relevance 0.31
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by direct anti-angiogenic effect to endothelial cells and pericytes and by inhibiting pericyte mediated endothelial cell survival mechanisms [46].
Negative_regulation (inhibition) of PDGF in endothelial cell associated with cancer
8) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.74 Pain Relevance 0
Overexpression of PDGF were observed in desmoid tumors, while inhibition of PDGF signaling by imatinib induced overall 1 year tumor control rate of 36.8% in a phase II clinical study [15].
Negative_regulation (inhibition) of PDGF associated with cancer and desmoid disease
9) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.64 Pain Relevance 0.06
Treatment with imatinib almost completely inhibited Leydig tumor growth in an allograft mouse model by inhibition of PDGF and c-kit signaling with no drug-resistance development during imatinib treatment [36].
Negative_regulation (inhibition) of PDGF associated with cancer
10) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.91 Pain Relevance 0
The clinical success of imatinib/gleevec, a triple tyrosine kinase inhibitor of c-kit, PDGF and c-Abl signaling, in chronic myeloid leukemia [37] and gastrointestinal stromal tumors [38] has accelerated the development of molecular targeted cancer therapy.
Negative_regulation (inhibitor) of PDGF associated with leukemia, cancer and gastrointestinal stromal tumor
11) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.84 Pain Relevance 0

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