INT74529

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.41
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
endothelial cells 1
vessels 1
pericytes 1
smooth muscle cells 1
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 5 99.96 Very High Very High Very High
cytokine 75 94.88 High High
Inflammation 76 90.44 High High
fibrosis 138 76.32 Quite High
chemokine 33 63.76 Quite High
antagonist 16 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.96 Very High Very High Very High
Mycobacterium Infection 118 98.44 Very High Very High Very High
Cancer 383 96.84 Very High Very High Very High
Eczema 31 96.84 Very High Very High Very High
Gastrointestinal Stromal Tumor 120 93.36 High High
Adhesions 2 93.20 High High
INFLAMMATION 94 90.44 High High
Disease 121 88.68 High High
Hyperplasia 20 88.64 High High
Renal Cancer 8 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imatinib is a selective tyrosine kinase inhibitor which binds KIT, Bcr-Abl, PDGFA/PDGFB.
PDGFB Binding (binds) of
1) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.91 Pain Relevance 0
In chronic pancreatitis, PDGF A chain mRNA transcripts were also abundant, and 11 of 19 samples exhibited the PDGF B chain mRNA transcript.
PDGF Binding (abundant) of associated with chronic pancreatitis
2) Confidence 0.35 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.74 Pain Relevance 0.39
The PDGF isoforms exert their cellular effects by binding to and activating two structurally related protein tyrosine kinase receptors.
PDGF Binding (binding) of
3) Confidence 0.26 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC1780053 Disease Relevance 0.27 Pain Relevance 0
cDNA array screening for potential PDGF-inducible genes
PDGF Binding (screening) of
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.03
In this regard, PDGF has been shown to be essential for the stability of normal blood vessel formation by recruiting pericytes and smooth muscle cells [40].
PDGF Binding (recruiting) of in smooth muscle cells
5) Confidence 0.20 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.76 Pain Relevance 0
Pericytes expressing PDGFRs migrate along steep gradient of PDGF-B in the peri-endothelial compartment to endothelial cells and thus initiate intimate association with the abluminal surface of the endothelial cells [41].
PDGF Binding (association) of in endothelial cells
6) Confidence 0.20 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.75 Pain Relevance 0
On the one hand PDGF increases survival and proliferation of endothelial cells and on the other hand, PDGF regulates vessel growth via pericyte recruitment and association to newly formed vessels.


PDGF Binding (association) of in vessels
7) Confidence 0.19 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.64 Pain Relevance 0
Different from PDGF-A and -B, PDGF-C and PDGF-D require proteolytic activation before binding to and activation of PDGFR [19,20].
PDGF Binding (binding) of
8) Confidence 0.19 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.39 Pain Relevance 0.03
PDGF exerts its biological activity by binding to structurally similar PDGF receptors (PDGFR-?
PDGF Binding (binding) of
9) Confidence 0.19 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.39 Pain Relevance 0.04
Different from PDGF-A and -B, PDGF-C and PDGF-D require proteolytic activation before binding to and activation of PDGFR [19,20].
PDGF Binding (binding) of
10) Confidence 0.19 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.40 Pain Relevance 0.03
Interestingly, a molecular network centered around the homodimer of PDGFB (i.e.
PDGFB Binding (homodimer) of
11) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.88 Pain Relevance 0.09
In this regard, PDGF has been shown to be essential for the stability of normal blood vessel formation by recruiting pericytes and smooth muscle cells [40].
PDGF Binding (recruiting) of in pericytes
12) Confidence 0.07 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.76 Pain Relevance 0
Simplified Information System (SIS)
SIS Binding (Simplified) of
13) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791232 Disease Relevance 0.51 Pain Relevance 0

General Comments

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