INT74530

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.56
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
pancreas 3
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 20 98.26 Very High Very High Very High
cytokine 1 73.16 Quite High
Inflammation 25 68.72 Quite High
aspirin 5 47.36 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 166 99.44 Very High Very High Very High
Hypereosinophilic Syndrome 1 99.42 Very High Very High Very High
Pancreatitis 24 99.32 Very High Very High Very High
Rhinitis 62 98.88 Very High Very High Very High
Frailty 4 97.32 Very High Very High Very High
Disease 27 95.24 Very High Very High Very High
Fibrosis 4 94.92 High High
Eczema 31 91.00 High High
Hyperplasia 4 88.80 High High
Adhesions 2 71.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the normal human pancreas, PDGF A chain mRNA levels were relatively abundant, whereas PDGF B chain mRNA levels were not detected, and type beta PDGF receptor mRNA transcripts were present at low levels.
Neg (not) Transcription (detected) of PDGF in pancreas
1) Confidence 0.65 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.73 Pain Relevance 0.31
In the normal human pancreas, PDGF A chain mRNA levels were relatively abundant, whereas PDGF B chain mRNA levels were not detected, and type beta PDGF receptor mRNA transcripts were present at low levels.
Transcription (abundant) of PDGF in pancreas
2) Confidence 0.65 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.73 Pain Relevance 0.30
In addition, there was a significant increase in the mRNA levels of type beta PDGF receptor in the pancreatitis samples by comparison with the normal pancreas (P < 0.001).
Transcription (levels) of PDGF in pancreas associated with pancreatitis
3) Confidence 0.59 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.73 Pain Relevance 0.40
In chronic pancreatitis, PDGF A chain mRNA transcripts were also abundant, and 11 of 19 samples exhibited the PDGF B chain mRNA transcript.
Transcription (transcript) of PDGF associated with chronic pancreatitis
4) Confidence 0.50 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.73 Pain Relevance 0.40
However, a PDGFRA mutation was associated with Gleevac-sensitive hypereosinophilic syndrome (HES), so perhaps decreased PDGFB-related transcription is also associated with an eosinophilic response.
Transcription (transcription) of PDGFB associated with rhinitis and hypereosinophilic syndrome
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.03 Pain Relevance 0.07
In addition, PDGF-B mRNA expression was weak but quantitatively able to be detected by real-time RT-PCR and showed no significant change among the clones (Figure 5A).
Transcription (expression) of PDGF-B
6) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.26 Pain Relevance 0
Next, we examined the EBC1 cell-derived mRNA levels of human VEGF-A, VEGF-C and PDGF-B in implanted tumor tissues as described in Methods.
Spec (examined) Transcription (levels) of PDGF-B associated with cancer
7) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.28 Pain Relevance 0
The authors' contibutions to this research are reflected in the order shown, with the exception of SSV who supervised the research and the preparation of the manuscript.
Neg (exception) Transcription (exception) of SSV
8) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.07 Pain Relevance 0

General Comments

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