INT74531

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Context Info
Confidence 0.26
First Reported 1998
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 7.57
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
endothelial cells 3
leukocytes 2
fibroblasts 2
smooth muscle 1
acinar cells 1
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 35 99.80 Very High Very High Very High
chemokine 141 99.74 Very High Very High Very High
Inflammation 54 97.80 Very High Very High Very High
Kappa opioid receptor 8 90.92 High High
cytokine 43 88.20 High High
isoflurane 5 87.76 High High
fibrosis 19 87.44 High High
anesthesia 6 86.88 High High
opioid receptor 1 86.00 High High
Opioid 1 74.40 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 42 99.80 Very High Very High Very High
INFLAMMATION 58 97.80 Very High Very High Very High
Mycobacterium Infection 118 97.68 Very High Very High Very High
Wound Healing 10 96.36 Very High Very High Very High
Injury 18 94.56 High High
Fibrosis 26 92.84 High High
Cirrhosis 1 87.44 High High
Frailty 7 86.60 High High
Rhinitis 62 86.24 High High
Increased Venous Pressure Under Development 2 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate the effect of PDGF release rate on PDGF biological function in vivo, nine groups of 3 animals each were prepared to test in a rat wound healing model. [24] They were grouped as follows:
Spec (investigate) Regulation (effect) of PDGF associated with wound healing
1) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.10 Pain Relevance 0.13
By controlling the MW of the MS over a range of 6.5 KDa┬ľ64 KDa, release rates of PDGF can be regulated over periods of weeks to months in vitro.
Regulation (regulated) of PDGF
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.16 Pain Relevance 0.04
These chemokines seem not to influence PDGF functions on cell migration and proliferation because Nirodi et. al. reported [37] that there was no CXC receptor II (CXCR2) for CXCL1, 2 and 5 in normal human skin, while CXCR2 was found to be rich within endothelial cells, indicating these PDGF-inducible chemokines in the current study play a role in angiogenesis.
Neg (not) Spec (seem) Regulation (influence) of PDGF in endothelial cells associated with chemokine
3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.30
These results indicate that tissue penetration and specimen area are dependent on in vivo PDGF release rate.
Regulation (dependent) of PDGF
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.10
However, a major obstacle for its successful clinical application is the delivery system, which ultimately controls the in vivo release rate of PDGF.
Regulation (controls) of PDGF
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.09 Pain Relevance 0.04
In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.
Regulation (immunoreactivity) of PDGF in leukocytes associated with chronic pancreatitis
6) Confidence 0.25 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41
The rational of targeting PDGF signaling in radiation oncology can arise in three ways: 1) the direct antitumoral potential, 2) the anti-angiogenic impact, and 3) the antifibrotic activity which protects normal tissue from the side effects of ionising radiation.
Regulation (targeting) of PDGF
7) Confidence 0.24 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.51 Pain Relevance 0.18
In the normal pancreas, PDGF immunoreactivity was present in islet cells, whereas type beta PDGF receptor immunoreactivity was present in acinar cells.
Regulation (immunoreactivity) of PDGF in acinar cells
8) Confidence 0.22 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.74 Pain Relevance 0.33
In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.
Regulation (immunoreactivity) of PDGF in leukocytes associated with chronic pancreatitis
9) Confidence 0.22 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41
(PDGFb) and regulated on activation of normal T cell expressed and secreted (RANTES).
Regulation (regulated) of PDGFb in T cell
10) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.32 Pain Relevance 0.12
A down-regulated PDGFB homodimer-centric network involving several smooth muscle-related genes was also identified (Figure 4).
Regulation (regulated) of PDGFB in smooth muscle
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.91 Pain Relevance 0.28
In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.
Regulation (immunoreactivity) of PDGF in endothelial cells associated with chronic pancreatitis
12) Confidence 0.09 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41
In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.
Regulation (immunoreactivity) of PDGF in fibroblasts associated with chronic pancreatitis
13) Confidence 0.09 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41
In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.
Regulation (immunoreactivity) of PDGF in fibroblasts associated with chronic pancreatitis
14) Confidence 0.08 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41
In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.
Regulation (immunoreactivity) of PDGF in endothelial cells associated with chronic pancreatitis
15) Confidence 0.08 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41
Although this did not appear to affect the quality of SIS, urban PHC staff acknowledged a minimal understanding of leprosy management indicating capacity-building of urban PHC staff was compromised.
Spec (appear) Regulation (affect) of SIS associated with mycobacterium infection
16) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791232 Disease Relevance 0.51 Pain Relevance 0
In oligodendrocytes, it also decreased with cAMP, but increased under the effect of bFGF and PDGF-BB.
Regulation (effect) of PDGF-BB in oligodendrocytes
17) Confidence 0.01 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.08 Pain Relevance 0.40

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