INT74545

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 7.77
Pain Relevance 16.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
stroma 2
hepatocytes 2
glial cell 2
synaptic cleft 2
neurons 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 503 100.00 Very High Very High Very High
Morphine 64 100.00 Very High Very High Very High
Dorsal horn 14 100.00 Very High Very High Very High
Thermal hyperalgesia 12 100.00 Very High Very High Very High
antagonist 29 99.86 Very High Very High Very High
intrathecal 42 99.60 Very High Very High Very High
tolerance 21 99.22 Very High Very High Very High
Antinociceptive 11 98.62 Very High Very High Very High
narcan 8 98.34 Very High Very High Very High
Endep 7 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 42 100.00 Very High Very High Very High
Diabetic Cardiomyopathies 210 99.96 Very High Very High Very High
Diabetes Mellitus 362 99.82 Very High Very High Very High
Coronary Heart Disease 16 99.58 Very High Very High Very High
Nociception 41 97.72 Very High Very High Very High
Poisoning 45 97.24 Very High Very High Very High
Injury 44 95.92 Very High Very High Very High
Carcinoma 2 95.76 Very High Very High Very High
Apoptosis 262 94.32 High High
Pancreatitis 4 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the levels of PKC alpha, beta I, or beta II isozymes in these fractions were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (levels) of PKC associated with kinase c
1) Confidence 0.42 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.90 Pain Relevance 1.85
Infusion of NMDA antagonist D-AP5 prevented both the thermal hyperalgesia and the increase in PKC gamma expression in PTX-treated rats.
Negative_regulation (prevented) of Gene_expression (expression) of PKC associated with kinase c, thermal hyperalgesia and antagonist
2) Confidence 0.42 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.91 Pain Relevance 2.01
The phorbol ester and protein kinase C (PKC) activator, phorbol dibutyrate (PDBU), was observed to produce an over 100% elevation of Iscc but only a small yet significant 20-30% decrease of TER across rat distal colon.
Negative_regulation (decrease) of Gene_expression (produce) of PKC in colon associated with kinase c
3) Confidence 0.42 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539661 Disease Relevance 0 Pain Relevance 0.37
The latter observation led Sen et al, to propose that differential expression of PKC?
Spec (propose) Negative_regulation (propose) of Gene_expression (expression) of PKC associated with kinase c
4) Confidence 0.41 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.34
The results obtained were unexpected; the prediction was that because of low expression of PKC?
Negative_regulation (low) of Gene_expression (expression) of PKC associated with kinase c
5) Confidence 0.41 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.15
are found in cell bodies within the superficial dorsal horn, where PKC?
Negative_regulation (where) of Gene_expression (found) of PKC in dorsal horn associated with kinase c and dorsal horn
6) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.41 Pain Relevance 1.21
These results show that acute amitriptyline treatment preserved morphine's antinociceptive effect in morphine-tolerant rats; the mechanisms may be involved in inhibition of phospho-PKA and PKC expression, and thus inducing the GLAST and GLT-1 trafficking onto glial cell surface which enhances the EAA uptake from the synaptic cleft and reduces EAA concentration in the spinal CSF.
Negative_regulation (inhibition) of Gene_expression (expression) of PKC in synaptic cleft associated with antinociceptive, endep and morphine
7) Confidence 0.34 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.65
Expression of PKC substrate proteins, GAP-43 and neurogranin, is downregulated by cAMP signaling and alterations in synaptic activity.
Negative_regulation (downregulated) of Gene_expression (Expression) of PKC
8) Confidence 0.24 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 18005072 Disease Relevance 0 Pain Relevance 0.18
As taurine treatment reduced the hepatic H2O2 production, As-induced PKC?
Negative_regulation (reduced) of Gene_expression (production) of PKC associated with kinase c
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.38 Pain Relevance 0.58
PKC family consists of at least 12 members and can be classified into three groups based on their biochemical properties and sequence homologies, e.g. conventional PKC isoforms (cPKC-?
Negative_regulation (conventional) of Gene_expression (isoforms) of PKC associated with kinase c
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.32 Pain Relevance 0.49
PKC family consists of at least 12 members and can be classified into three groups based on their biochemical properties and sequence homologies, e.g. conventional PKC isoforms (cPKC-?
Negative_regulation (conventional) of Gene_expression (isoforms) of PKC associated with kinase c
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.33 Pain Relevance 0.50
and pre-treatment of hepatocytes with its inhibitor, rottlerin, suppressed the activation of JNK indicating that PKC?
Negative_regulation (suppressed) of Gene_expression (indicating) of PKC in hepatocytes
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.90 Pain Relevance 0
However, in our present study, except PKC?
Negative_regulation (However) of Neg (except) Gene_expression (except) of PKC
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.31 Pain Relevance 0
Another interesting finding in the present study was the presence of PKM fragment of PKC in ShhMSCs at 72-h after transfection with Shh plasmid.
Negative_regulation (presence) of Gene_expression (fragment) of PKC
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.08 Pain Relevance 0.03
This study showed that breviscapine has a protective effect on DCM, which is dose related.174 Breviscapine also prevented cardiac hypertrophy in diabetic rats by inhibiting the expression of PKC, which may have a protective effect in the pathogenesis of DCM via the PKC/NF-?
Negative_regulation (inhibiting) of Gene_expression (expression) of PKC associated with diabetes mellitus, diabetic cardiomyopathies and coronary heart disease
15) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.26 Pain Relevance 0.03
Treatment with breviscapine reversed the cardiac dysfunction and structure changes in rats with DCM, decreased the expression of PKC, and increased the expression of calcium handling regulators, ie, protein phosphatase inhibitor-1, phospholamban, and SERCA2.
Negative_regulation (decreased) of Gene_expression (expression) of PKC associated with diabetic cardiomyopathies
16) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.15 Pain Relevance 0.04
In situ assessment of PKC activity using eGFP-MARCKS
Negative_regulation (assessment) of Gene_expression (activity) of PKC associated with kinase c
17) Confidence 0.17 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.31
F/Fo: 0.88 ± 0.22, 89.79 ± 16.3% of control, n = 6 cells, 2 dishes) or the specific PKC inhibitor BIM (1 ?
Negative_regulation (inhibitor) of Gene_expression (specific) of PKC associated with kinase c
18) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.06 Pain Relevance 0.16
F/Fo: 0.88 ± 0.22, 89.79 ± 16.3% of control, n = 6 cells, 2 dishes) or the specific PKC inhibitor BIM (1 ?
Negative_regulation (inhibitor) of Gene_expression (0.22) of PKC associated with kinase c
19) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.06 Pain Relevance 0.16
The percentages of neurons co-expressing CB/PKCgamma in the total numbers of CB- and PKCgamma-immunoreactive neurons were 6.7 and 5.9%, respectively.
Negative_regulation (numbers) of Gene_expression (co-expressing) of PKCgamma in neurons
20) Confidence 0.06 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0.07 Pain Relevance 0.33

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