INT74556

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
nucleus accumbens 2
brain 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 18 100.00 Very High Very High Very High
Inflammation 5 100.00 Very High Very High Very High
gABA 22 99.96 Very High Very High Very High
Analgesic 2 99.80 Very High Very High Very High
Nucleus accumbens 5 99.52 Very High Very High Very High
Calcitonin gene-related peptide 1 96.64 Very High Very High Very High
cannabis 4 96.60 Very High Very High Very High
Cannabinoid receptor 2 96.16 Very High Very High Very High
tolerance 2 95.84 Very High Very High Very High
qutenza 6 94.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 100.00 Very High Very High Very High
Anxiety Disorder 122 97.60 Very High Very High Very High
Psychosis 1 95.92 Very High Very High Very High
Schizophrenia 2 92.84 High High
Nociception 1 90.44 High High
Pressure And Volume Under Development 2 78.40 Quite High
Hyperalgesia 4 75.00 Quite High
Urological Neuroanatomy 1 71.84 Quite High
Stress 42 50.00 Quite Low
Post-traumatic Stress Disorder 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbens.
Negative_regulation (decreases) of cannabinoid 1 receptor Binding (binding) of in nucleus accumbens associated with nucleus accumbens, analgesic and cannabinoid
1) Confidence 0.59 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 15995876 Disease Relevance 0.26 Pain Relevance 0.56
Collectively, these results indicate that cannabinoids reduce inflammation via interaction with a peripheral CB1 receptor.
Negative_regulation (reduce) of CB1 receptor Binding (interaction) of associated with inflammation and cannabinoid
2) Confidence 0.54 Published 1998 Journal Pain Section Abstract Doc Link 9539680 Disease Relevance 0.64 Pain Relevance 1.18
Chronic exposure to Delta(9)-THC caused a significant reduction in CB1 receptor binding in all brain areas that contain this receptor.
Negative_regulation (reduction) of CB1 receptor Binding (binding) of in brain
3) Confidence 0.25 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10760375 Disease Relevance 0 Pain Relevance 0.34
Recently, Azad et al. [99] have shown that CB1 receptors reduce GABA-ergic synaptic transmission in the amygdale, and consequently facilitate
Negative_regulation (reduce) of CB1 Binding (receptors) of associated with gaba and cannabinoid
4) Confidence 0.21 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 0.23 Pain Relevance 0.59

General Comments

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