INT74563

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2011
Negated 6
Speculated 5
Reported most in Body
Documents 258
Total Number 265
Disease Relevance 168.18
Pain Relevance 34.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
neutrophils 14
macrophages 10
plasma 10
granulocytes 10
embryos 9
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2773 100.00 Very High Very High Very High
cytokine 1291 100.00 Very High Very High Very High
cocaine 1168 100.00 Very High Very High Very High
Adalimumab 511 99.98 Very High Very High Very High
agonist 236 99.98 Very High Very High Very High
qutenza 133 99.98 Very High Very High Very High
rheumatoid arthritis 251 99.90 Very High Very High Very High
Oxycodone 2 99.76 Very High Very High Very High
ischemia 331 99.74 Very High Very High Very High
Nicotine 238 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 6375 100.00 Very High Very High Very High
INFLAMMATION 3185 100.00 Very High Very High Very High
Hypoxia 454 100.00 Very High Very High Very High
Urological Neuroanatomy 97 100.00 Very High Very High Very High
Hyperglycemia 209 99.98 Very High Very High Very High
Disease 2016 99.96 Very High Very High Very High
Apoptosis 3547 99.92 Very High Very High Very High
Rheumatoid Arthritis 258 99.92 Very High Very High Very High
Diabetes Mellitus 2046 99.90 Very High Very High Very High
Anaemia 12 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NSAIDs and short-chain fatty acids under study all possess a carboxyl group, and this carboxyl group is essential for salicylic acid's ability to increase ROS production.
Positive_regulation (increase) of Gene_expression (production) of ROS associated with cinod
1) Confidence 0.61 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9540818 Disease Relevance 0.52 Pain Relevance 0.56
In sharp contrast, normal keratinocytes did not show increases in ROS levels and were not killed.
Neg (not) Positive_regulation (increases) of Gene_expression (levels) of ROS in keratinocytes
2) Confidence 0.57 Published 2009 Journal J Drugs Dermatol Section Body Doc Link 19180893 Disease Relevance 0.12 Pain Relevance 0
Increased ROS production leads to tissue damage associated with inflammation.
Positive_regulation (Increased) of Gene_expression (production) of ROS associated with inflammation
3) Confidence 0.55 Published 2008 Journal Iran J Allergy Asthma Immunol Section Abstract Doc Link 19052348 Disease Relevance 1.46 Pain Relevance 0.44
Activation of polymorphonuclear leucocytes and macrophages leads to increased production of ROS [102].
Positive_regulation (leads) of Gene_expression (production) of ROS in macrophages
4) Confidence 0.51 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.63 Pain Relevance 0.24
Metal ions can also increase the production of ROS directly through the Haber-Weiss reaction.
Positive_regulation (increase) of Gene_expression (production) of ROS
5) Confidence 0.51 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.18 Pain Relevance 0
MEASUREMENTS AND MAIN RESULTS: Thiopental-treated lymphocytes exhibited an overgeneration of ROS, but no change was detected in mitochondrial glutathione quantity.
Positive_regulation (overgeneration) of Gene_expression (overgeneration) of ROS in lymphocytes
6) Confidence 0.50 Published 2004 Journal J Clin Anesth Section Body Doc Link 15217658 Disease Relevance 0 Pain Relevance 0
ROS generation may play a part in the exposure of PS.
Positive_regulation (generation) of Gene_expression (generation) of ROS
7) Confidence 0.49 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16309195 Disease Relevance 0.43 Pain Relevance 0.11
Errors of spermiogenesis associated with the retention of excess residual cytoplasm appear to be associated with oxidative stress as a consequence of enhanced ROS production by uncharacterised 'oxidases', plasma membrane electron transport chains or oxidoreductases capable of activating redox-cycling xenobiotics.
Positive_regulation (enhanced) of Gene_expression (production) of ROS in plasma associated with stress
8) Confidence 0.47 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.57 Pain Relevance 0
Examples of such compounds include endocrine disruptors with estrogenic properties that are capable of inducing ROS production by male germ cells and initiating free radical-mediated DNA damage [47].
Positive_regulation (inducing) of Gene_expression (production) of ROS in male germ cells
9) Confidence 0.47 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.09 Pain Relevance 0
While these glial responses are beneficial to neurons, the continuous or repeated activation of astrocytes and microglia under conditions of chronic inflammatory stresses can lead to the increased production of ROS/RNS and other neurotoxic mediators, which can lead to severe neuronal damage (Banati et al., 1993; Banati and Graeber, 1994; Aloisi, 2001; Streit, 2002).
Positive_regulation (increased) of Gene_expression (production) of ROS in astrocytes associated with stress and inflammation
10) Confidence 0.46 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.68 Pain Relevance 0.33
The results of this study demonstrate that platycodon D mediates ROS production, and that this mediation is followed by a decrease in mitochondrial membrane potential (MMP, DJm), activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP).
Positive_regulation (mediates) of Gene_expression (production) of ROS in poly
11) Confidence 0.44 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.82 Pain Relevance 0.12
Decreased UCP2 expression results in increased ROS production, in vitro [19], while animal studies have shown that absence of UCP2 causes higher oxidative stress [20].
Positive_regulation (increased) of Gene_expression (production) of ROS associated with stress
12) Confidence 0.41 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.92 Pain Relevance 0
Our results demonstrate a novel mechanism of sulindac-induced apoptosis in human MM cells, namely, accumulation of p53, Bax, and Bak in mitochondria mediated by p38 MAPK activation downstream of ROS production.
Positive_regulation (activation) of Gene_expression (production) of ROS associated with multiple myeloma and apoptosis
13) Confidence 0.41 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.11 Pain Relevance 0
ROS production was assessed by the peak time (PT) of ROS production and area under the luminol reaction curve (AUC), which represents total ROS production quantity against opsonized zymosan stimuli.
Positive_regulation (represents) of Gene_expression (production) of ROS
14) Confidence 0.41 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.13 Pain Relevance 0.25
Propofol and droperidol could not induce any perturbative effect on the oxidative state of T cells, whereas succinylcholine was found to markedly affect lymphocyte oxidative state both by impairing glutathione content and promoting exaggerated production of ROS.
Positive_regulation (promoting) of Gene_expression (production) of ROS in lymphocyte
15) Confidence 0.41 Published 2004 Journal J Clin Anesth Section Body Doc Link 15217658 Disease Relevance 0 Pain Relevance 0
Arachidonic acid was also found to increase ROS generation, and could synergize with indomethacin in this reaction.
Positive_regulation (increase) of Gene_expression (generation) of ROS
16) Confidence 0.41 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9540818 Disease Relevance 0.57 Pain Relevance 0.55
In addition, inhibitors of NADPH oxidase, diphenylene iodonium, apocynin and neopterine, profoundly blocked the capsaicin-induced ROS generation and apoptosis.
Positive_regulation (induced) of Gene_expression (generation) of ROS associated with qutenza and apoptosis
17) Confidence 0.39 Published 2004 Journal Free Radic. Res. Section Abstract Doc Link 15190937 Disease Relevance 1.14 Pain Relevance 0.95
Although DWN resulted in an increase in ROS production, the increase occurred after the peak decline in muscle function and DOMS, suggesting that there may be a disassociation in the temporal relationship between ROS, loss of muscle function and DOMS.
Positive_regulation (increase) of Gene_expression (production) of ROS in muscle associated with myalgia
18) Confidence 0.38 Published 2004 Journal Eur. J. Appl. Physiol. Section Abstract Doc Link 14685863 Disease Relevance 0.72 Pain Relevance 0.04
In both populations of dopaminergic neurons, the auto-oxidation of dopamine itself and its metabolites can lead to the production of ROS, which is worsened by abundant content of iron and copper in this region (Olney et al., 1990; Jenner et al., 1992).
Positive_regulation (lead) of Gene_expression (production) of ROS in dopaminergic neurons associated with dopamine
19) Confidence 0.37 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.04 Pain Relevance 0.33
In the hippocampus, astrocytes in the CA1 region under ischemia, display selective loss of glutamate transport activity, increased mitochondrial ROS generation, and reduced mitochondrial membrane potential.
Positive_regulation (increased) of Gene_expression (generation) of ROS in hippocampus associated with glutamate, ischemia and hippocampus
20) Confidence 0.37 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.77 Pain Relevance 0.36

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