INT7457

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2005
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 2.75
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
lung 2
myocytes 1
sensory nerves 1
C127 1
reticulum 1
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 20 97.84 Very High Very High Very High
fibrosis 40 97.60 Very High Very High Very High
Calcium channel 2 95.88 Very High Very High Very High
agonist 10 92.80 High High
tetrodotoxin 1 92.04 High High
antagonist 2 90.88 High High
ischemia 48 81.32 Quite High
cerebral cortex 2 75.00 Quite High
Glutamate 9 63.60 Quite High
imagery 8 62.44 Quite High
Disease Link Frequency Relevance Heat
Inborn Genetic Diseases 8 99.76 Very High Very High Very High
Stress 64 99.20 Very High Very High Very High
Hypoxia 64 98.92 Very High Very High Very High
Cystic Fibrosis 40 98.16 Very High Very High Very High
INFLAMMATION 20 97.84 Very High Very High Very High
Pressure And Volume Under Development 216 96.68 Very High Very High Very High
Colitis 6 86.72 High High
Inflammatory Bowel Disease 1 82.96 Quite High
Cv Unclassified Under Development 48 81.32 Quite High
Glioma 8 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ryanodine, a blocker of the sarcoplasmic reticulum calcium-induced calcium release channel, was also without effect.
Localization (release) of channel in reticulum
1) Confidence 0.60 Published 1992 Journal Glia Section Abstract Doc Link 1349589 Disease Relevance 0 Pain Relevance 0.35
The excitatory responses of deflationary slowly adapting pulmonary stretch receptor (SAR) activity to lung deflation ranging from approximately -15 to -25 cm of H(2)O for approximately 5 s were examined before and after administration of flecainide, a Na(+) channel blocker, and K(+) channel blockers, such as 4-aminopyridine (4-AP) and tetraethylammonium (TEA).
Spec (examined) Localization (administration) of channel in lung
2) Confidence 0.42 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805222 Disease Relevance 0 Pain Relevance 0
The excitatory responses of deflationary slowly adapting pulmonary stretch receptor (SAR) activity to lung deflation ranging from approximately -15 to -25 cm of H(2)O for approximately 5 s were examined before and after administration of flecainide, a Na(+) channel blocker, and K(+) channel blockers, such as 4-aminopyridine (4-AP) and tetraethylammonium (TEA).
Spec (examined) Localization (administration) of channel in lung
3) Confidence 0.42 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805222 Disease Relevance 0 Pain Relevance 0
The vanilloid receptor subtype-1 (VR-1) is a cation channel located on the sensory nerves that, when stimulated, release proinflammatory peptides.
Localization (release) of channel in sensory nerves
4) Confidence 0.02 Published 2004 Journal J. Gastrointest. Surg. Section Abstract Doc Link 15531237 Disease Relevance 0.68 Pain Relevance 0.16
Maxi-anion channel as an ATP-releasing pathway
Localization (releasing) of channel
5) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.33 Pain Relevance 0
The swelling-induced release of ATP from neonatal rat ventricular myocytes was sensitive to the anion channel blockers SITS and NPPB, suggesting an electrogenic mechanism of ATP release via an anion channel.
Localization (release) of channel in myocytes associated with pressure and volume under development
6) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.63 Pain Relevance 0.11
The structural basis for channel-mediated ATP release remains obscure.
Localization (release) of channel
7) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0 Pain Relevance 0
Connexin as an ATP-releasing channel
Localization (releasing) of channel
8) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.07 Pain Relevance 0.03
Thus, it is possible that Cx expression upregulates the activity of an ATP-releasing anion channel which is distinct from the Cx-hemichannel.
Localization (releasing) of channel
9) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.25 Pain Relevance 0.06
Recent advances in crystallographic methods may provide us with a biophysically solid framework for understanding channel-mediated ATP release.
Localization (release) of channel
10) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0 Pain Relevance 0
CFTR as an ATP-releasing channel
Localization (releasing) of channel
11) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.45 Pain Relevance 0.14
Cardiac ATP release and maxi-anion channel activity shared the same pharmacological profile and were sensitive to Gd3+ and arachidonic acid, which are the most effective blockers of maxi-anion channels in C127 cells [115, 213].
Localization (release) of channel in C127
12) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.34 Pain Relevance 0

General Comments

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