INT74579

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 5.57
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)
Anatomy Link Frequency
plasma 2
eosinophils 2
C5AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 96.40 Very High Very High Very High
Inflammatory response 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 416 100.00 Very High Very High Very High
Eosinophilia 3 99.96 Very High Very High Very High
Flavivirus Infection 320 99.70 Very High Very High Very High
Pressure And Volume Under Development 2 99.26 Very High Very High Very High
Pain 5 96.40 Very High Very High Very High
Fever 5 94.60 High High
Infection 152 93.92 High High
Erythema 1 93.72 High High
Disease 68 92.64 High High
Thrombocytopenia 32 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A case of episodic angioedema associated with blood eosinophilia: upregulated C5a receptor expression on eosinophils.
Positive_regulation (upregulated) of Gene_expression (expression) of C5a in eosinophils associated with pressure and volume under development and eosinophilia
1) Confidence 0.67 Published 1998 Journal Allergy Section Title Doc Link 9542615 Disease Relevance 0.74 Pain Relevance 0.10
In addition, clinical studies have shown that the levels of dengue NS1 and products of complement activation, including those with a known vascular effect, such as C3a, C5a, and sC5b-9, are present in higher levels in DHF patients before plasma leakage takes place, supporting the theory that complement activation is involved in the development of severe disease [12] and to deleterious patient outcomes [11], [13], [14].
Positive_regulation (activation) of Gene_expression (levels) of C5a in plasma associated with flavivirus infection, dengue and disease
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.03 Pain Relevance 0
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Positive_regulation (consumption) of Gene_expression (production) of C5a associated with flavivirus infection
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.02 Pain Relevance 0
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Positive_regulation (increased) of Gene_expression (production) of C5a associated with flavivirus infection
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.01 Pain Relevance 0
DHF patients have elevated levels of the anaphylotoxins C3a and C5a
Positive_regulation (elevated) of Gene_expression (levels) of C5a associated with flavivirus infection
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.76 Pain Relevance 0

General Comments

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