INT74586

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.68
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8)
proteinaceous extracellular matrix (MMP8)
Anatomy Link Frequency
sulcus 1
fibroblasts 1
periodontium 1
neutrophil 1
MMP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 105 99.28 Very High Very High Very High
cINOD 3 88.96 High High
Inflammation 94 83.36 Quite High
visual analogue scale 3 79.20 Quite High
Pain 7 79.04 Quite High
rheumatoid arthritis 21 76.00 Quite High
Arthritis 16 74.16 Quite High
cytokine 36 67.04 Quite High
fibrosis 2 63.04 Quite High
corticosteroid 3 61.80 Quite High
Disease Link Frequency Relevance Heat
Gingival Overgrowth 10 96.60 Very High Very High Very High
INFLAMMATION 116 83.36 Quite High
Wound Healing 15 81.04 Quite High
Pain 7 79.04 Quite High
Rheumatoid Arthritis 21 75.00 Quite High
Rheumatic Diseases 1 75.00 Quite High
Disease 62 74.52 Quite High
Chronic Periodontitis 3 70.72 Quite High
Nicotine Addiction 22 69.20 Quite High
Endotoxemia 2 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the documented favourable clinical response may in part be due to in vivo inhibition of classic neutrophil and mesenchymal collagenase/MMP-8 activities produced by doxycycline.
Negative_regulation (inhibition) of MMP-8 in neutrophil
1) Confidence 0.27 Published 1998 Journal Rheumatol. Int. Section Abstract Doc Link 9542777 Disease Relevance 0.41 Pain Relevance 0.50
Chlodronate was able to inhibit MMP-8 in peri-implant sulcus fluid [123].


Negative_regulation (inhibit) of MMP-8 in sulcus
2) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.42 Pain Relevance 0.31
This finding is in agreement with in-vitro and in-vivo studies which report a relative reduction in MMP-1 and MMP-8/TIMP-1 in gingival fibroblasts and in serum and GCF concentration in CSA-associated gingival overgrowth subjects [50,51].
Negative_regulation (reduction) of MMP-8 in fibroblasts associated with gingival overgrowth
3) Confidence 0.06 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.21 Pain Relevance 0.04
Reverse transcription polymerase chain reaction was performed for the collagenases (MMP-1, MMP-8, MMP-13), the stromelysins (MMP-3, MMP-10, MMP-11), and the tissue inhibitors of metalloproteinase (TIMP-1, TIMP-2, TIMP-3, TIMP-4).
Negative_regulation (inhibitors) of MMP-8
4) Confidence 0.02 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0
A recent study on 19 periodontal patients scheduled for flap surgery demonstrated that short term therapy with SDD alone reduced levels of proteolytic enzymes, while low dose flurbiprofen alone had no significant effect; combined medication with both agents resulted in statistically significant synergistic reduction in collagenase, gelatinase, serpinolytic activities and to a lesser extent, elastase activity [62].
Negative_regulation (reduction) of collagenase
5) Confidence 0.00 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.39 Pain Relevance 0.39
Subantimicrobial dosing with doxycycline (SDD; 20mg bd) has been shown to consistently reduce the activity of mammalian collagenase and other matrix metalloproteinases in the tissues of the periodontium.
Negative_regulation (reduce) of collagenase in periodontium associated with metalloproteinase
6) Confidence 0.00 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.24 Pain Relevance 0.40

General Comments

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