INT74587

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 33
Disease Relevance 24.40
Pain Relevance 14.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8)
proteinaceous extracellular matrix (MMP8)
Anatomy Link Frequency
plaque 4
neutrophil 4
teeth 3
chondrocytes 2
blood 2
MMP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 334 100.00 Very High Very High Very High
Angina 160 99.84 Very High Very High Very High
Inflammatory stimuli 1 99.74 Very High Very High Very High
Pain 34 99.36 Very High Very High Very High
Inflammation 666 98.66 Very High Very High Very High
cytokine 65 91.24 High High
Opioid 1 85.20 High High
chemokine 5 84.36 Quite High
Neuropeptide 4 84.28 Quite High
iatrogenic 3 78.56 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 123 99.84 Very High Very High Very High
Hemorrhage 130 99.68 Very High Very High Very High
INFLAMMATION 701 99.58 Very High Very High Very High
Pain 22 99.36 Very High Very High Very High
Acute Coronary Syndrome 175 99.04 Very High Very High Very High
Injury 137 98.96 Very High Very High Very High
Disease 108 98.84 Very High Very High Very High
Coronary Artery Disease 100 98.80 Very High Very High Very High
Atherosclerotic Plaque 33 98.64 Very High Very High Very High
Rupture 55 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These results suggest that capsaicin-evoked neurogenic gingival inflammation can trigger the expression and activation of MMP-8 in GCF of the adjacent teeth.


Gene_expression (expression) of MMP-8 in teeth
1) Confidence 0.78 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
To elucidate whether MMP-1, MMP-8 and MMP-13 levels in blood were high in patients with unstable angina (UAP), we measured serum MMP-1 and plasma MMP-8 and MMP-13 levels in 45 patients with UAP, 175 with stable coronary artery disease (CAD), and 45 controls.
Gene_expression (levels) of MMP-8 in blood associated with angina and coronary artery disease
2) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.15 Pain Relevance 0.84
Notably, MMP-8 levels were higher in patients with stable CAD than in controls (median 3.5ng/ml vs. 2.8ng/ml, P<0.005), however, MMP-8 levels in patients with UAP were much higher than those in stable CAD (3.9ng/ml vs. 3.5ng/ml, P<0.05).
Gene_expression (levels) of MMP-8 associated with angina and coronary artery disease
3) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.59 Pain Relevance 1.16
Thus, plasma MMP-8 levels were found to be high in patients with UAP, suggesting that MMP-8 levels in UAP may reflect coronary plaque instability and that MMP-8 is a promising biomarker for UAP.
Gene_expression (levels) of MMP-8 in plaque associated with angina
4) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.61 Pain Relevance 1.09
To elucidate whether MMP-1, MMP-8 and MMP-13 levels in blood were high in patients with unstable angina (UAP), we measured serum MMP-1 and plasma MMP-8 and MMP-13 levels in 45 patients with UAP, 175 with stable coronary artery disease (CAD), and 45 controls.
Gene_expression (levels) of MMP-8 in blood associated with angina and coronary artery disease
5) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.03 Pain Relevance 0.81
High levels of MMPs mRNA and proteins, especially MMP-1, MMP-2, MMP-8, MMP-9, and MMP-13, were shown in human atherosclerotic plaques.
Gene_expression (levels) of MMP-8 in plaques associated with atherosclerotic plaque and metalloproteinase
6) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 0.64 Pain Relevance 0.59
Thus, plasma MMP-8 levels were found to be high in patients with UAP, suggesting that MMP-8 levels in UAP may reflect coronary plaque instability and that MMP-8 is a promising biomarker for UAP.
Gene_expression (levels) of MMP-8 in plaque associated with angina
7) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.57 Pain Relevance 1.07
Notably, MMP-8 levels were higher in patients with stable CAD than in controls (median 3.5ng/ml vs. 2.8ng/ml, P<0.005), however, MMP-8 levels in patients with UAP were much higher than those in stable CAD (3.9ng/ml vs. 3.5ng/ml, P<0.05).
Gene_expression (levels) of MMP-8 associated with angina and coronary artery disease
8) Confidence 0.61 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.58 Pain Relevance 1.16
Western immunoblot revealed that both neutrophil- and mesenchymal-type MMP-8 isoforms were elevated and activated, together with 110 kDa high-molecular size MMP-8 species.
Gene_expression (elevated) of MMP-8 in neutrophil
9) Confidence 0.59 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
In multivariate analysis, MMP-8 level was an independent factor for UAP.
Gene_expression (level) of MMP-8 associated with angina
10) Confidence 0.53 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.53 Pain Relevance 1.11
During the experiments, no marked changes occurred in MMP-8 levels in the GCF of distantly located teeth.
Gene_expression (levels) of MMP-8 in teeth
11) Confidence 0.53 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
The molecular forms of MMP-8 in the GCF of stimulated and non-stimulated teeth were analyzed by Western immunoblot, and MMP-8 levels by quantitative immunofluorometric assay.
Spec (analyzed) Gene_expression (levels) of MMP-8 in teeth associated with metalloproteinase
12) Confidence 0.53 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 15790739 Disease Relevance 0.33 Pain Relevance 1.01
Analysis of these data indicated that pulpal pain can induce local elevations in MMP-8 levels in GCF.
Gene_expression (levels) of MMP-8 associated with pain and metalloproteinase
13) Confidence 0.53 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 15790739 Disease Relevance 0.36 Pain Relevance 0.94
MMP8 Matrix metalloproteinase 8
Gene_expression (metalloproteinase) of MMP8 associated with metalloproteinase
14) Confidence 0.51 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.62 Pain Relevance 0.40
Transcripts encoding the potent pro-inflammatory calgranulins proteins S100A8/9 and S100A12, characteristic of granulocyte neutrophil activity [51] and involved in a diversity of inflammatory diseases [56], as well as the granulocyte-related metalloprotease MMP8 are also over-expressed.
Gene_expression (expressed) of MMP8 in granulocyte associated with inflammation and disease
15) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.73 Pain Relevance 0.32
These results indicate that the documented favourable clinical response may in part be due to in vivo inhibition of classic neutrophil and mesenchymal collagenase/MMP-8 activities produced by doxycycline.
Gene_expression (produced) of MMP-8 in neutrophil
16) Confidence 0.38 Published 1998 Journal Rheumatol. Int. Section Abstract Doc Link 9542777 Disease Relevance 0.40 Pain Relevance 0.49
Women with PPROM had elevated levels of MMP-8.
Gene_expression (levels) of MMP-8
17) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1769412 Disease Relevance 0.24 Pain Relevance 0.04
MMP-8 and MMP-9 were detected in all the samples.
Gene_expression (detected) of MMP-8 associated with metalloproteinase
18) Confidence 0.25 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.08 Pain Relevance 0.69
MMP-8 is a collagenase produced by neutrophils, but also by endothelial cells, smooth muscle cells and macrophages in plaques.
Gene_expression (produced) of MMP-8 in neutrophils
19) Confidence 0.23 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.69 Pain Relevance 0.21
For clinical relevance, we compared the diagnostic performance of the MR score against glucose, WBC count, LDH, IL-6, and MMP-8 by using the clinical laboratory cutoffs previously reported in the literature [18,19,21,22].
Gene_expression (count) of MMP-8
20) Confidence 0.20 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1769412 Disease Relevance 0.91 Pain Relevance 0.25

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