INT7459

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 6.96
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
Anatomy Link Frequency
plasma 3
liver 2
heart 2
tail 1
skeletal muscles 1
Lpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
beta blocker 2 100.00 Very High Very High Very High
antagonist 6 99.52 Very High Very High Very High
Catecholamine 19 99.24 Very High Very High Very High
Clonidine 5 97.68 Very High Very High Very High
Action potential 1 96.04 Very High Very High Very High
Restless leg syndrome 31 88.36 High High
aspirin 6 82.48 Quite High
tolerance 4 79.20 Quite High
withdrawal 1 69.68 Quite High
Pain 10 62.16 Quite High
Disease Link Frequency Relevance Heat
Shock 3 99.88 Very High Very High Very High
Obesity 42 99.32 Very High Very High Very High
Panic Disorder 6 99.22 Very High Very High Very High
Diabetes Mellitus 115 98.48 Very High Very High Very High
Hypertension 13 97.56 Very High Very High Very High
Body Weight 19 97.24 Very High Very High Very High
Ganglion Cysts 3 96.12 Very High Very High Very High
Disorder Of Lipid Metabolism 63 93.68 High High
Increased Venous Pressure Under Development 57 91.36 High High
Stress 22 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of reserpine, alpha-methyldopa and clonidine on the activity of lipoprotein lipase (LPL) of the rabbit heart and the effect of reserpine on the LPL activity of the cardiac tissue of normotonic and spontaneously hypertensive rats was investigated by a modified method of Robinson, Reserpine and alpha-methyldopa caused in the rabbit heart muscle a pronounced increase in LPL activity by 74 and 35%, respectively.
Positive_regulation (increase) of LPL in heart associated with hypertension and clonidine
1) Confidence 0.70 Published 1980 Journal Acta Biol. Med. Ger. Section Abstract Doc Link 7282227 Disease Relevance 0.26 Pain Relevance 0.22
Application of reserpine increases the LPL activity in the hearts both of normotonic and spontaneously hypertensive rats.
Positive_regulation (increases) of LPL in hearts associated with hypertension
2) Confidence 0.70 Published 1980 Journal Acta Biol. Med. Ger. Section Abstract Doc Link 7282227 Disease Relevance 0.26 Pain Relevance 0.22
In female Sprague-Dawley rats, TPM also increased energy expenditure and it has been observed to increase LPL activity in brown adipose tissue, which could indicate that TPM has the ability to enhance regulatory thermogenesis.
Positive_regulation (increase) of LPL in adipose tissue associated with obesity
3) Confidence 0.62 Published 2000 Journal Nutrition Section Abstract Doc Link 11054602 Disease Relevance 0.58 Pain Relevance 0
In addition, TPM stimulates LPL activity in skeletal muscles, further emphasizing its potential to promote substrate oxidation.
Positive_regulation (stimulates) of LPL in skeletal muscles
4) Confidence 0.45 Published 2000 Journal Nutrition Section Abstract Doc Link 11054602 Disease Relevance 0.50 Pain Relevance 0
PLS also identified a correlation between decreased plasma lipids and increased hepatic lipoprotein lipase (LPL) at days 7 and 14 (figure 6B) and confirmed the association between decreased in glucokinase expression and decreased hepatic glycogen.


Positive_regulation (increased) of LPL in plasma
5) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.08 Pain Relevance 0
PLS also identified a correlation between decreased plasma lipids and increased hepatic lipoprotein lipase (LPL) at days 7 and 14 (figure 6B) and confirmed the association between decreased in glucokinase expression and decreased hepatic glycogen.


Positive_regulation (increased) of lipoprotein lipase in plasma
6) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.08 Pain Relevance 0
Furthermore, in one study provided on patients with panic disorder authors was found correlation between increased activity of lipoprotein lipase, cholesterol, and catecholamines concentrations (14).
Positive_regulation (increased) of lipoprotein lipase associated with panic disorder and catecholamine
7) Confidence 0.17 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816847 Disease Relevance 0.78 Pain Relevance 0.12
In these studies researchers pointed out that norepinephrine increase the activity of lipoprotein lipase, and the result of increased activity of lipoprotein lipase is increase of free fatty acids in the serum, which in turn may be converted by the liver into cholesterol.
Positive_regulation (increase) of lipoprotein lipase in liver
8) Confidence 0.17 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816847 Disease Relevance 0.66 Pain Relevance 0.12
In these studies researchers pointed out that norepinephrine increase the activity of lipoprotein lipase, and the result of increased activity of lipoprotein lipase is increase of free fatty acids in the serum, which in turn may be converted by the liver into cholesterol.
Positive_regulation (increased) of lipoprotein lipase in liver
9) Confidence 0.17 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816847 Disease Relevance 0.71 Pain Relevance 0.12
Particularly, plasma triglycerides concentration is reduced after exercise training by increasing lipoprotein lipase activity in plasma clearing triglycerides from circulation and replenishing it to the skeletal muscle stores to the process of excitation-contraction coupling (27).
Positive_regulation (increasing) of lipoprotein lipase in plasma
10) Confidence 0.13 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.63 Pain Relevance 0
Previous studies have shown that the primary fatty acid
component in serum from dialysis patients is OA, and that the increased
concentration is caused by activation of lipoprotein lipase by administered
heparin (22,
23). 
Positive_regulation (activation) of lipoprotein lipase
11) Confidence 0.06 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2596408 Disease Relevance 0 Pain Relevance 0
These extracts restored the activities of enzyme lipoprotein lipase (LPL) that was reduced and glucose-6-phosphatase and lactate dehydrogenase, which were raised in untreated diabetics [36].
Positive_regulation (restored) of lipoprotein lipase associated with diabetes mellitus
12) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275761 Disease Relevance 1.00 Pain Relevance 0.04
LPL16 is FMRFamide immunoreactive; it is excited by tail shock; and stimulation of LPL16 produces inhibition of siphon sensory cell-to-motor cell postsynaptic potentials and narrowing of action potentials in the sensory cells in tetraethylammonium solution.
Positive_regulation (stimulation) of LPL16 in tail associated with action potential and shock
13) Confidence 0.02 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1349637 Disease Relevance 0.44 Pain Relevance 0.08
The activity of lipoprotein lipase that determines the catabolism of very low density lipoproteins (VLDL) is decreased by the beta-blocker propranolol and increased by alpha 1-antagonists.
Positive_regulation (increased) of lipoprotein lipase associated with beta blocker and antagonist
14) Confidence 0.02 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455133 Disease Relevance 0.12 Pain Relevance 0.39
In general, the effects of prolactin on body mass and testes found in the present study are consistent with the evidence that high prolactin levels during late breeding phase decrease fat stores [31] by affecting lipid metabolism via increasing lipoprotein lipase activity in the adipocytes [32] and induce testicular regression by inhibiting the hypothalamo-hypophyseal-gonadal axis [4,7,13].
Positive_regulation (increasing) of lipoprotein lipase in adipocytes associated with obesity
15) Confidence 0.01 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC538291 Disease Relevance 0.19 Pain Relevance 0
The mechanism is unclear but it is thought to be related to increased levels of cAMP, increased lipoprotein lipase activity, and attenuated triglyceride secretion (Motoyashiki et al 1996; Elam et al 1998).
Positive_regulation (increased) of lipoprotein lipase
16) Confidence 0.01 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544362 Disease Relevance 0.68 Pain Relevance 0.48

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