INT74592

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.05
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal cord 2
central nervous system 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 12 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Central nervous system 2 98.40 Very High Very High Very High
nMDA receptor antagonist 2 98.28 Very High Very High Very High
Glutamate receptor 5 96.68 Very High Very High Very High
Hyperalgesia 2 93.00 High High
withdrawal 1 91.24 High High
Opioid 1 85.36 High High
Neuropathic pain 3 84.72 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 144 99.40 Very High Very High Very High
Hyperalgesia 2 93.00 High High
Neuropathic Pain 4 84.72 Quite High
Non-diabetic Peripheral Neuropathy 1 72.28 Quite High
Ganglion Cysts 9 53.36 Quite High
Diabetes Mellitus 3 49.12 Quite Low
Diabetic Retinopathy 4 45.12 Quite Low
Glaucoma 2 44.12 Quite Low
Retinal Diseases 3 43.64 Quite Low
Death 1 30.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute effects of subcutaneously injected morphine on transcripts of the NMDA receptor subunits NR1, NR2A and NR2B in certain areas of the central nervous system of male rats were examined by Northern blot analysis.
Spec (examined) Regulation (effects) of Transcription (transcripts) of NR1 in central nervous system associated with nmda receptor, central nervous system and morphine
1) Confidence 0.60 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.60
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Neg (not) Regulation (change) of Transcription (levels) of NR1 in spinal cord associated with spinal cord
2) Confidence 0.40 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.79
Our results focused on mRNA expression and not protein expression or functional NMDAR changes after hypoxia and recovery.
Neg (not) Regulation (focused) of Transcription (expression) of NMDAR associated with hypoxia
3) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.56 Pain Relevance 0.12

General Comments

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