INT74593

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.21
Pain Relevance 5.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
caudate putamen 1
brain 1
forebrain 1
central nervous system 1
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 43 100.00 Very High Very High Very High
Morphine 26 99.92 Very High Very High Very High
Central nervous system 2 99.00 Very High Very High Very High
Central grey 2 98.76 Very High Very High Very High
butorphanol 9 98.44 Very High Very High Very High
Hippocampus 32 97.76 Very High Very High Very High
Intracerebroventricular 3 97.74 Very High Very High Very High
Physical dependence 2 96.36 Very High Very High Very High
Pain 7 96.20 Very High Very High Very High
amygdala 12 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 10 96.36 Very High Very High Very High
Pain 7 96.20 Very High Very High Very High
Urological Neuroanatomy 4 93.84 High High
Anxiety Disorder 47 93.72 High High
Cognitive Disorder 13 92.76 High High
Nociception 2 75.00 Quite High
Schizophrenia 10 63.68 Quite High
Psychosis 8 5.00 Very Low Very Low Very Low
Hallucination 4 5.00 Very Low Very Low Very Low
Amnesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute effects of subcutaneously injected morphine on transcripts of the NMDA receptor subunits NR1, NR2A and NR2B in certain areas of the central nervous system of male rats were examined by Northern blot analysis.
Transcription (transcripts) of NR2B in central nervous system associated with nmda receptor, central nervous system and morphine
1) Confidence 0.66 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.61
Although NVP-AAM077 could act at NR2B as well, it is unlikely that the NVP-AAM077 effect was mediated by NR2B-NMDARs, because similar treatment with the selective NR2B-NMDAR antagonist ifenprodil (0.2 ?
Transcription (act) of NR2B associated with antagonist
2) Confidence 0.54 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.23 Pain Relevance 0.17
The results indicate that the use of siRNA targeting the NR2B subunit not only decreased the expression of NR2B mRNA and its associated protein, as demonstrated by real-time PCR and Western blotting, but also abolished formalin-induced pain behaviors in rat model.
Transcription (expression) of NR2B associated with pain
3) Confidence 0.53 Published 2005 Journal Gene Ther. Section Abstract Doc Link 15470478 Disease Relevance 0.34 Pain Relevance 0.61
Results of NR 2 B mRNA and protein detections showed no significant differences among the 5 groups in their expression (P>0.05).
Transcription (detections) of NR 2 B
4) Confidence 0.50 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 20209972 Disease Relevance 0 Pain Relevance 0
Continuous intracerebroventricular (i.c.v.) infusion with butorphanol (26 nmol/microl/h) resulted in significant modulations in the NRI, NR2A, and NR2B mRNA levels.
Transcription (levels) of NR2B associated with butorphanol and intracerebroventricular
5) Confidence 0.39 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.31
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Transcription (levels) of NR2B in forebrain associated with nmda receptor
6) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.29
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Transcription (mRNA) of NR2B associated with cognitive disorder and morphine
7) Confidence 0.33 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.51
In the caudate putamen, mRNA levels of GluR3, NR2A, and NR2B receptor subunits were significantly increased.
Transcription (levels) of NR2B in caudate putamen
8) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.13 Pain Relevance 0.38
The expression of NR2A and NR2B subunit mRNAs did not change after morphine treatment in any brain region.
Transcription (expression) of NR2B in brain associated with morphine
9) Confidence 0.05 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 1.18
Using in situ hybridization techniques, the effects of chronic morphine treatment on the expression of mRNAs encoding the NMDA receptor subunits NRI, NR2A, and NR2B were investigated.
Transcription (expression) of NR2B associated with nmda receptor and morphine
10) Confidence 0.04 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 0.92

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