INT74594

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 1999
Negated 1
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
brain 2
central nervous system 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
nMDA receptor 6 100.00 Very High Very High Very High
Central nervous system 1 99.00 Very High Very High Very High
Central grey 1 98.76 Very High Very High Very High
Hippocampus 3 97.76 Very High Very High Very High
amygdala 1 95.68 Very High Very High Very High
Nucleus accumbens 1 95.28 Very High Very High Very High
Intracerebroventricular 1 87.52 High High
Opioid 2 86.56 High High
tolerance 2 85.20 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 93.84 High High
Drug Dependence 1 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute effects of subcutaneously injected morphine on transcripts of the NMDA receptor subunits NR1, NR2A and NR2B in certain areas of the central nervous system of male rats were examined by Northern blot analysis.
Spec (examined) Regulation (effects) of Transcription (transcripts) of NR2B in central nervous system associated with nmda receptor, central nervous system and morphine
1) Confidence 0.42 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.61
The expression of NR2A and NR2B subunit mRNAs did not change after morphine treatment in any brain region.
Neg (not) Regulation (change) of Transcription (expression) of NR2B in brain associated with morphine
2) Confidence 0.03 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 1.19

General Comments

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