INT74595

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.66
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
spinal cord 2
central nervous system 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 12 100.00 Very High Very High Very High
nMDA receptor 4 100.00 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Central nervous system 1 98.64 Very High Very High Very High
nMDA receptor antagonist 1 98.28 Very High Very High Very High
Hyperalgesia 2 93.00 High High
withdrawal 1 91.24 High High
Opioid 2 85.84 High High
Neuropathic pain 3 84.72 Quite High
Hippocampus 2 80.24 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 93.00 High High
Cognitive Disorder 3 92.76 High High
Neuropathic Pain 4 84.72 Quite High
Non-diabetic Peripheral Neuropathy 1 72.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Neg (not) Regulation (change) of Transcription (levels) of NR2A in spinal cord associated with spinal cord
1) Confidence 0.42 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.79
The acute effects of subcutaneously injected morphine on transcripts of the NMDA receptor subunits NR1, NR2A and NR2B in certain areas of the central nervous system of male rats were examined by Northern blot analysis.
Spec (examined) Regulation (effects) of Transcription (transcripts) of NR2A in central nervous system associated with nmda receptor, central nervous system and morphine
2) Confidence 0.41 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.61
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Spec (whether) Regulation (altered) of Transcription (mRNA) of NR2A associated with cognitive disorder and morphine
3) Confidence 0.22 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52

General Comments

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