INT74596

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 0.94
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh3) signal transducer activity (Hrh3)
Anatomy Link Frequency
neurons 2
medial vestibular nucleus 2
ileum 1
aorta 1
striatum 1
Hrh3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
agonist 43 99.84 Very High Very High Very High
Enkephalin 20 99.84 Very High Very High Very High
antagonist 46 97.36 Very High Very High Very High
allodynia 1 97.24 Very High Very High Very High
trk C 2 96.96 Very High Very High Very High
Deafferentation 10 96.52 Very High Very High Very High
noradrenaline 14 91.72 High High
Central nervous system 27 89.84 High High
ASIC 12 88.88 High High
Disease Link Frequency Relevance Heat
Nociception 15 97.88 Very High Very High Very High
Catalepsy 3 97.32 Very High Very High Very High
Neuropathic Pain 1 97.24 Very High Very High Very High
Syndrome 18 92.92 High High
Ocular Toxicity (including Many Sub-types) 15 88.64 High High
Increased Venous Pressure Under Development 1 74.04 Quite High
Ganglion Cysts 19 68.40 Quite High
Dizziness 6 58.08 Quite High
Nystagmus 11 56.68 Quite High
Targeted Disruption 3 54.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strong H3-receptor mRNA expression in enkephalin neurons suggests that the synergistic neurochemical and motor effects of ciproxifan and haloperidol result from direct H3/D2-receptor interactions, leading to an enhanced activation of striatopallidal neurons of the indirect movement pathway.
Gene_expression (expression) of H3-receptor in neurons associated with enkephalin
1) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12177222 Disease Relevance 0.10 Pain Relevance 0.58
The majority ( approximately 70%) of striatal enkephalin neurons express H3-receptor mRNAs.
Gene_expression (express) of H3-receptor in neurons associated with enkephalin
2) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12177222 Disease Relevance 0 Pain Relevance 0.43
This important degree of coexpression of proenkephalin and H3-receptor mRNAs prompted us to explore the effect of H3-receptor ligands on the regulation of enkephalin mRNA expression in the striatum.
Gene_expression (coexpression) of H3-receptor in striatum associated with enkephalin
3) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12177222 Disease Relevance 0 Pain Relevance 0.46
This study involves analysis of trends observed in mRNA expression levels for the H3 receptor (H3X, the oligonucleotide probe detecting all H3 receptor mRNAs characterized so far) as well as three of the known functionally active isoforms (H3A, H3B, and H3C), described by Drutel et al. [24], during the process of post-lesional plasticity in the central nervous system (CNS).
Gene_expression (expression) of H3 receptor in central nervous system associated with central nervous system
4) Confidence 0.65 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC517932 Disease Relevance 0 Pain Relevance 0.33
After 1 week post-lesion, H3 receptor mRNA expression levels (as indicated by probe H3X) returned to normal levels.
Gene_expression (expression) of H3 receptor mRNA
5) Confidence 0.65 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC517932 Disease Relevance 0 Pain Relevance 0.03
Histamine H3 receptor desensitization in the guinea-pig ileum.
Gene_expression (desensitization) of Histamine H3 receptor in ileum
6) Confidence 0.59 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9543246 Disease Relevance 0 Pain Relevance 0.13
We compared the total H3 receptor mRNA expression levels (using probe H3X) in ipsilateral MVe of control animals to that of test animals from the four time points (Fig. 1A).
Gene_expression (expression) of H3 receptor mRNA in MVe
7) Confidence 0.50 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC517932 Disease Relevance 0 Pain Relevance 0.04
Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat

Background

Gene_expression (expression) of H3 receptor
8) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Title Doc Link PMC517932 Disease Relevance 0.18 Pain Relevance 0.12
Expression levels for histamine H3 receptor (total) as well as three isoforms which display variable lengths of the third intracellular loop of the receptor were analyzed using in situ hybridization on brain sections containing the rat medial vestibular nucleus after unilateral labyrinthectomy.
Spec (analyzed) Gene_expression (Expression) of H3 receptor in medial vestibular nucleus
9) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC517932 Disease Relevance 0.16 Pain Relevance 0.13
The inhibitory effect of 3.2 microM WIN 55,212-2 on the evoked overflow from the guinea-pig aorta was comparable in size to that obtained with agonists at the histamine H3, kappa opioid (KOP) and ORL1 (NOP) receptor (1 or 10 microM, producing the respective near-maximum effects) whereas prostaglandin E2 1 microM caused a higher near-maximum inhibition of 70%.
Gene_expression (producing) of histamine H3 in aorta associated with agonist and opioid
10) Confidence 0.15 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16195872 Disease Relevance 0 Pain Relevance 0.45
The larger caliber arterial afferents express the histamine receptor 3, which is implicated in intense pressure mechanical nociception and allodynia [46].
Gene_expression (express) of histamine receptor 3 associated with nociception and allodynia
11) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.39 Pain Relevance 0.25
Studies using RT-PCR and immunoblotting and immunocytochemical experiments in frog and mouse semicircular canal sensory epithelia showed that both frog and mouse vestibular epithelia express H1 receptors, although no clear evidence for H3 receptor expression in hair cells was found [19].
Gene_expression (expression) of H3 receptor in semicircular canal
12) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.11 Pain Relevance 0.18

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