INT74599

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (YY1, ADCY1) plasma membrane (YY1, ADCY1) cell differentiation (YY1)
small molecule metabolic process (ADCY1) intracellular (YY1) GTPase activity (ADCY1)
YY1 (Homo sapiens)
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
agonist 5 97.20 Very High Very High Very High
bradykinin 1 96.60 Very High Very High Very High
medulla 2 75.00 Quite High
antagonist 1 74.64 Quite High
Pain 1 64.72 Quite High
Enkephalin 2 52.80 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 1 88.92 High High
Neuroblastoma 2 88.56 High High
Pain 1 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
delta Negative_regulation (inhibition) of adenylyl cyclase associated with opioid receptor and bradykinin
1) Confidence 0.36 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.17
In contrast, the deltaOR/SNSR-4 bivalent agonist BAM22, which could activate each receptor expressed individually, fully activated the SNSR-4-dependent phospholipase C but did not promote deltaOR-mediated inhibition of adenylyl cyclase in deltaOR/SNSR-4-coexpressing cells.
deltaOR Negative_regulation (inhibition) of adenylyl cyclase associated with agonist
2) Confidence 0.00 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682504 Disease Relevance 0.06 Pain Relevance 0.50

General Comments

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