INT74600

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.17

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nucleus (YY1, ADCY1) plasma membrane (YY1, ADCY1) cell differentiation (YY1)
small molecule metabolic process (ADCY1) intracellular (YY1) GTPase activity (ADCY1)
YY1 (Homo sapiens)
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
bradykinin 1 96.60 Very High Very High Very High
Analgesic 1 25.00 Low Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 1 89.24 High High
Neuroblastoma 2 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
Negative_regulation (blocked) of delta Negative_regulation (inhibition) of adenylyl cyclase associated with opioid receptor and bradykinin
1) Confidence 0.36 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.17

General Comments

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