INT74602

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.19

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cytosol (PLCB1) signal transduction (PLCB1) nucleus (PLCB1)
enzyme binding (PLCB1) cytoplasm (PLCB1) signal transducer activity (PLCB1)
PLCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 1 100.00 Very High Very High Very High
opioid receptor 3 97.78 Very High Very High Very High
Analgesic 1 25.00 Low Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 1 83.64 Quite High
Neuroblastoma 2 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
Negative_regulation (inhibition) of Positive_regulation (activation) of phospholipase C associated with opioid receptor and bradykinin
1) Confidence 0.41 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.19

General Comments

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