INT74613

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GCC1) plasma membrane (GCC1) cytoplasm (GCC1)
Anatomy Link Frequency
reticulum 1
GCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 114 87.88 High High
cannabis 32 80.04 Quite High
cocaine 56 79.64 Quite High
Pain 2 69.20 Quite High
addiction 6 68.08 Quite High
alcohol 8 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Nucleus accumbens 4 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 100.00 Very High Very High Very High
Peripheral Arterial Disease 9 99.92 Very High Very High Very High
Diabetes Mellitus 21 99.52 Very High Very High Very High
Disorder Of Lipid Metabolism 16 92.96 High High
Drug Dependence 116 87.88 High High
Cardiovascular Disease 18 82.24 Quite High
Phencyclidine Abuse 8 81.12 Quite High
Obesity 8 79.36 Quite High
Stress 6 72.00 Quite High
Pain 2 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
34), representing a number of consistently changed functional classes: Calmodulin-related transcripts (CALM1, CALM2, CAMK2B) were decreased, while transcripts related to cholesterol biosynthesis and trafficking (FDFT1, APOL2, SCARB1), and Golgi/endoplasmic reticulum (ER) functions (SEMA3B, GCC1) were all increased.
Positive_regulation (ll increa) of GCC1 in reticulum
1) Confidence 0.43 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762434 Disease Relevance 0.77 Pain Relevance 0.40
Transcripts involved in various aspects of Golgi/ER function (YIPF5, GCC1, COG4, COPZ1, VPS37C, LEPREL1, CPVL, SEMA3B) were increased.
Positive_regulation (increased) of GCC1
2) Confidence 0.29 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.13 Pain Relevance 0.09
Non-insulin dependent diabetes (NIDDM) is associated with an increased risk of peripheral vascular disease (PVD), but within the diabetic population the relationship between lipid profile and PVD has not been clearly defined.
Positive_regulation (increased) of peripheral vascular disease associated with diabetes mellitus, peripheral arterial disease and increased venous pressure under development
3) Confidence 0.00 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9544725 Disease Relevance 1.43 Pain Relevance 0.07

General Comments

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