INT74629

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.78
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp7) extracellular region (Mmp7) proteinaceous extracellular matrix (Mmp7)
Anatomy Link Frequency
eye 3
brain 2
plasma 1
cartilage 1
articular 1
Mmp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 193 100.00 Very High Very High Very High
cINOD 4 99.36 Very High Very High Very High
Osteoarthritis 64 99.16 Very High Very High Very High
ischemia 30 98.96 Very High Very High Very High
Neuritis 15 98.88 Very High Very High Very High
Snapping jaw 47 98.72 Very High Very High Very High
Chronic pancreatitis 8 98.12 Very High Very High Very High
cytokine 46 98.00 Very High Very High Very High
Catecholamine 2 97.04 Very High Very High Very High
Inflammatory mediators 4 93.60 High High
Disease Link Frequency Relevance Heat
Necrosis 23 100.00 Very High Very High Very High
Cancer 19 100.00 Very High Very High Very High
Injury 16 99.88 Very High Very High Very High
Experimental Autoimmune Neuritis 12 99.84 Very High Very High Very High
Pancreatic Cancer 4 99.84 Very High Very High Very High
Transient Ischemic Attack 16 99.72 Very High Very High Very High
Pressure And Volume Under Development 11 99.40 Very High Very High Very High
Brain Hemorrhage 11 99.32 Very High Very High Very High
INFLAMMATION 64 99.24 Very High Very High Very High
Osteoarthritis 76 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we test if matrix metalloproteinase 7 (MMP-7), a secreted protease frequently expressed in pancreatic carcinoma, can be measured in plasma, pancreatic, and duodenal juice, and if it can distinguish between periampullary carcinoma and chronic pancreatitis.
Gene_expression (expressed) of MMP-7 in plasma associated with pancreatic cancer, metalloproteinase, carcinoma and chronic pancreatitis
1) Confidence 0.55 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17507610 Disease Relevance 1.24 Pain Relevance 0.56
Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barré syndrome.
Gene_expression (expressed) of MMP-7 associated with syndrome, experimental autoimmune neuritis, metalloproteinase and neuritis
2) Confidence 0.47 Published 1998 Journal Ann. Neurol. Section Title Doc Link 9546322 Disease Relevance 1.05 Pain Relevance 0.66
Janusz et al10 demonstrated a reduction in chondropathy following MMP inhibition with an Matrix Metalloproteinase inhibitor (MMPi) inhibitor, structurally related to hydroxamic acid (Proctor and Gamble) in a meniscal injury model of OA.
Neg (inhibition) Gene_expression (inhibition) of Metalloproteinase associated with injury, metalloproteinase and osteoarthritis
3) Confidence 0.12 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 1.10 Pain Relevance 0.98
Matrix metalloproteinase expression during experimental autoimmune neuritis.
Gene_expression (expression) of metalloproteinase associated with experimental autoimmune neuritis, metalloproteinase and neuritis
4) Confidence 0.10 Published 1998 Journal Brain Section Title Doc Link 9549524 Disease Relevance 1.21 Pain Relevance 0.98
Nonsteroidal anti-inflammatory drugs in orthodontic tooth movement: metalloproteinase activity and collagen synthesis by endothelial cells.
Gene_expression (synthesis) of metalloproteinase in endothelial cells associated with inflammation, metalloproteinase and cinod
5) Confidence 0.06 Published 2000 Journal Am J Orthod Dentofacial Orthop Section Title Doc Link 10935962 Disease Relevance 0.26 Pain Relevance 0.37
Stroke index score, infarct volume, cerebral specific gravity, and the endogenous expression of tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in the brain tissue were quantified in the ischemic and matched contralateral nonischemic hemisphere.
Gene_expression (expression) of metalloproteinase in brain associated with necrosis, cancer, stroke and metalloproteinase
6) Confidence 0.04 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.62 Pain Relevance 0.55
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
Gene_expression (production) of metalloproteinase associated with brain hemorrhage, pressure and volume under development, necrosis, cancer, ischemia and metalloproteinase
7) Confidence 0.04 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 15729288 Disease Relevance 1.70 Pain Relevance 0.51
A recent study reported an increased incidence of ulcerative keratolysis with corneal perforation after topical fluoroquinolone treatment for microbial keratitis.[11] These findings led us to investigate the role of various commercially available fluoroquinolone eye drop formulations on the physiological remodeling of the corneal extracellular matrix by evaluating matrix metalloproteinase expression in cornea.
Gene_expression (expression) of metalloproteinase in eye associated with corneal perforation, metalloproteinase and keratitis
8) Confidence 0.03 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.51 Pain Relevance 0.18
To quantify the metalloproteinase expression after the application of fluoroquinolone eye drops, the four test groups were analyzed by western-blot and zymography.


Gene_expression (expression) of metalloproteinase in eye associated with metalloproteinase
9) Confidence 0.03 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0 Pain Relevance 0.05
Recent in vivo and in vitro studies indicate that the pathologic mechanism with fluoroquinolones may be related to significant increases of matrix-degrading proteolytic activity, inhibitory effects on cell metabolism, as well as the degenerative and ultrastructural cell changes with increased levels and interferences in the regulative pathways of several cytokines. [22-26] The clinical significance of these findings revolve around two main questions: how is the expression of these matrix metalloproteinase increased after the application of topical fluoroquinolone eye drops?
Gene_expression (expression) of metalloproteinase in eye associated with metalloproteinase and cytokine
10) Confidence 0.02 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.05 Pain Relevance 0.20
In peripheral blood monocytes and monocyte-derived macrophages, NE and epinephrine alone only show a minor effect on matrix metalloproteinase (MMP)-1 and MMP-9 production [39].
Gene_expression (production) of metalloproteinase in blood associated with metalloproteinase
11) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0.29
With respect to gonadal function, Adamts19 (a disintegrin and metalloproteinase domain, with thrombospondin type-1 modules), significantly up-regulated in 20% CR, 40% CR and HFG diets, has been shown to be expressed in multiple tissues, and in particular the testes [27], [28].
Gene_expression (expressed) of metalloproteinase in testes associated with metalloproteinase
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.40 Pain Relevance 0.10
Moreover, PDGF-BB facilitates degradation of extracellular matrix proteins by enhancement of MMP synthesis, but MMP activity was probably limited because of elevated tissue inhibitor of metalloproteinase 1 expression.


Gene_expression (expression) of metalloproteinase in extracellular matrix
13) Confidence 0.02 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
Estrogen modulation of matrix metalloproteinase (MMP) expression has also been observed in the cartilage of the TMJ [5,6]; high levels of MMP have been reported to play a role in TMJ osteoarthritis [7,8].
Gene_expression (expression) of metalloproteinase in cartilage associated with snapping jaw, metalloproteinase and osteoarthritis
14) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2811708 Disease Relevance 1.03 Pain Relevance 1.01
Agmatine has been reported to block the blood-brain barrier disruption by suppressing the expression of matrix metalloproteinase after transient cerebral ischemia (Kim et al., 2008).
Gene_expression (expression) of metalloproteinase in brain associated with transient ischemic attack, ischemia and metalloproteinase
15) Confidence 0.01 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0.63 Pain Relevance 0.21
Metalloproteinase expression and activity
Gene_expression (expression) of Metalloproteinase associated with metalloproteinase
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.60 Pain Relevance 0.08
Similarly, intra-articular injection of IL-1RA attenuated the development of cartilage lesions and metalloproteinase expression in canine models of OA [41].
Gene_expression (expression) of metalloproteinase in articular associated with metalloproteinase and osteoarthritis
17) Confidence 0.01 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 1.39 Pain Relevance 0.85

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox