INT74631

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.11
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (UBXN11) cytoplasm (UBXN11)
Anatomy Link Frequency
muscles 3
fibroblasts 2
brain 1
skin 1
UBXN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 77 99.50 Very High Very High Very High
imagery 7 99.08 Very High Very High Very High
anesthesia 3 97.84 Very High Very High Very High
Demyelination 2 96.16 Very High Very High Very High
Pain 7 92.52 High High
cytokine 16 35.08 Quite Low
fibrosis 55 21.76 Low Low
Inflammation 106 5.00 Very Low Very Low Very Low
Bile 26 5.00 Very Low Very Low Very Low
alcohol 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 99 99.96 Very High Very High Very High
Severe Combined Immunodeficiency 9 99.80 Very High Very High Very High
Hepatocellular Cancer 25 98.60 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 4 96.20 Very High Very High Very High
Demyelinating Disease 4 96.16 Very High Very High Very High
Adrenoleukodystrophy 17 95.96 Very High Very High Very High
Convulsion 2 95.00 High High
Muscle Hypotonia 2 94.60 High High
Rhabdomyolysis 4 93.12 High High
Neurological Disease 3 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-oxidation, producing succinyl-CoA and acetyl-CoA [115, 116].
Gene_expression (producing) of CoA
1) Confidence 0.75 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.46 Pain Relevance 0
Consequently, the reduced tyrosine phosphorylation of IRS-1 and IRS-2 in rat hepatoma cells exposed to palmitic acid can be reversed by inhibition of acyl-CoA synthesis of palmitoyl-CoA, suggesting an important role of FATP (ACSLV) proteins in insulin signaling [50].
Gene_expression (synthesis) of CoA associated with hepatocellular cancer
2) Confidence 0.75 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.95 Pain Relevance 0
-oxidation, producing succinyl-CoA and acetyl-CoA [115, 116].
Gene_expression (producing) of CoA
3) Confidence 0.75 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.46 Pain Relevance 0
Since LCFA-CoA production is controlled by FATPs, which channel acyl-CoAs to the synthesis of phospholipids, cholesterol esters, and triglycerides or oxidation by the mitochondrial and peroxisomal ?
Gene_expression (production) of CoA
4) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.19 Pain Relevance 0
In contrast, a slight increase in serum ketones in both fed and fasted animals (Table 1), together with unchanged levels of HMG-CoA synthase mRNA (Fig. 6B) and a significant increase in propionyl-CoA, an odd chain ?
Gene_expression (synthase mRNA) of CoA
5) Confidence 0.65 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.27 Pain Relevance 0
When a comparison between the products of glucose, glycogen, and palmitate oxidation to 8 acetyl CoA molecules is made, carbohydrate oxidation yields a higher proportion of NADH to FADH2, more CO2, and a greater ATP yield, even when accounting for the less ATP efficient glycerol-3-phosphate shuttle for electron transfer from glycolysis (NADH?
Gene_expression (molecules) of CoA
6) Confidence 0.65 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0 Pain Relevance 0
This suggests that oleic acid might inhibit elongation/desaturation processes either directly (e.g. as a competitive inhibitor of linoleoyl-CoA and alpha-linolenoyl-CoA formation) or by some indirect mechanism.
Gene_expression (formation) of CoA
7) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2875212 Disease Relevance 0.07 Pain Relevance 0
Defects in the VLCFA-CoA importer and in the racemase do not produce disease until a long time after the neonatal period.
Neg (not) Gene_expression (produce) of CoA associated with disease
8) Confidence 0.65 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.99 Pain Relevance 0.15
The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.
Gene_expression (defects) of CoA associated with adrenoleukodystrophy
9) Confidence 0.65 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.53 Pain Relevance 0.10
This suggests that oleic acid might inhibit elongation/desaturation processes either directly (e.g. as a competitive inhibitor of linoleoyl-CoA and alpha-linolenoyl-CoA formation) or by some indirect mechanism.
Gene_expression (formation) of CoA
10) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2875212 Disease Relevance 0.07 Pain Relevance 0
-oxiation is regulated by carnitine palmitoyltransferase (CPT1), carnitine concentration, and malonyl-CoA produced by acetyl CoA carboxylase (ACC2) from cytosolic acetyl-CoA.
Gene_expression (produced) of CoA
11) Confidence 0.58 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.43 Pain Relevance 0
selective agonist

(L165041) increases the expression of AcylCoA synthtase 2 (ASC2) in rat brain

Gene_expression (expression) of CoA in brain associated with agonist
12) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.23 Pain Relevance 0.13
Palmitoyl-CoA and behenoyl-CoA dehydrogenase in fibroblasts were deficient.
Gene_expression (deficient) of CoA in fibroblasts
13) Confidence 0.58 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546340 Disease Relevance 0.09 Pain Relevance 0.09
Palmitoyl-CoA and behenoyl-CoA dehydrogenase in fibroblasts were deficient.
Gene_expression (deficient) of CoA in fibroblasts
14) Confidence 0.58 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546340 Disease Relevance 0.09 Pain Relevance 0.09
A significant difference (p = 0.02) existed in the duration of swallowing between the SOC (1.472 seconds) and SNOC (1.327 seconds) groups.
Gene_expression (swallowing) of SOC
15) Confidence 0.20 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
No significant differences existed in the SEMG activity of the submental muscles between the SOC and SNOC groups (LDA, p = 0.4; RDA, p = 0.2).
Gene_expression (groups) of SOC in muscles
16) Confidence 0.20 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
A highly significant difference (p = 0.0001) existed between the SOC and SNOC groups in all the SEMG activation of the stomatognatic muscles (LTA, RTA, LMM, RMM).
Gene_expression (groups) of SOC in muscles
17) Confidence 0.20 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
No significant differences existed in the sternocleidomastoid muscles between the SOC and SNOC groups (LSC, p = 0.2; RSC, p = 0.3).
Gene_expression (groups) of SOC in muscles
18) Confidence 0.20 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
The findings of these three skin-tropic ORFs not only confirmed previous studies but also further verified the similarity between SCID-skin and SOC systems.
Gene_expression (systems) of SOC in skin associated with severe combined immunodeficiency
19) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2895648 Disease Relevance 1.26 Pain Relevance 0

General Comments

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