INT74632

Context Info Confidence 0.64 First Reported 1998 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 11 Total Number 12 Disease Relevance 3.93 Pain Relevance 3.56

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)

Anatomy Link Frequency blood 1 Plasma 1 uterus 1 bowel 1 Oxt (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 21 98.32 withdrawal 15 98.06 cannabis 3 97.84 Dismenorea 17 96.80 opiate 4 94.44 tolerance 13 93.48 Cannabinoid 7 92.80 analgesia 30 91.80 Neuropeptide 9 86.44 antagonist 15 85.52

Disease Link Frequency Relevance Heat Targeted Disruption 23 99.60 Opiate Addiction 8 98.24 Dysmenorrhea 12 96.80 Stress 70 91.08 Aggression 3 90.44 Reprotox - General 1 3 82.64 Drug Dependence 16 81.28 Anxiety Disorder 284 79.76 Cannabis Dependence 1 67.00 Appetite Loss 3 63.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Avp and Oxytocin mRNA in situ hybridization

Transcription (mRNA) of Oxytocin

1) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0 Pain Relevance 0

Detection of Oxt mRNA was performed by hybridization of a similarly specific 48-bp oligonucleotide (5?

Transcription (Detection) of Oxt

2) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.06 Pain Relevance 0

Oxytocin levels were assessed in a separate group of 15 children with inflammatory bowel disease with abdominal pain and in a control group of 79 healthy school children.

Transcription (levels) of Oxytocin in bowel

3) Confidence 0.53 Published 2004 Journal J. Pediatr. Gastroenterol. Nutr. Section Body Doc Link 15097440 Disease Relevance 0 Pain Relevance 0

Both control HT and KO mice showed higher OT mRNA expression levels than control WT group and these levels did not change after induced sodium intake.

Transcription (expression) of OT associated with targeted disruption

4) Confidence 0.52 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.29 Pain Relevance 0.05

Moreover, beta-endorphin mutated mice have similar higher levels of OT mRNA expression after the different conditions analyzed: basal, control or experimental, compared with WT mice.

Transcription (expression) of OT

5) Confidence 0.52 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.30 Pain Relevance 0.11

Both control HT and KO mice showed higher OT mRNA expression levels than control WT group and these levels did not change after induced sodium intake.

Transcription (levels) of OT associated with targeted disruption

6) Confidence 0.52 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.29 Pain Relevance 0.05

Plasma OT levels were analyzed by RIA after extraction.

Spec (analyzed) Transcription (levels) of OT in Plasma

7) Confidence 0.46 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9546727 Disease Relevance 0.79 Pain Relevance 1.60

RESULTS: All three groups included individuals prescribed OxyContin for pain and demographic variables and psychiatric/medical histories failed to discriminate between the pain and substance abuse (SA) subjects.

Transcription (prescribed) of OxyContin

8) Confidence 0.40 Published 2008 Journal J Opioid Manag Section Body Doc Link 18557163 Disease Relevance 0 Pain Relevance 0

To confirm this GeneChip data, reverse transcription-polymerase chain reaction (RT-PCR) was performed to measure the mRNA expression level of oxytocin in CaMKIV-/- mice (Fig. 5).

Transcription (expression) of oxytocin

9) Confidence 0.34 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.78 Pain Relevance 0.32

To confirm this GeneChip data, reverse transcription-polymerase chain reaction (RT-PCR) was performed to measure the mRNA expression level of oxytocin in CaMKIV-/- mice (Fig. 5).

Transcription (level) of oxytocin

10) Confidence 0.34 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.77 Pain Relevance 0.32

Additionally, the uterus itself may be a source of these hormones and we have recently found oxytocin mRNA in the endometrium of non-pregnant women with the highest levels around the time of ovulation.

Transcription (found) of oxytocin in uterus

11) Confidence 0.10 Published 2004 Journal Rocz. Akad. Med. Bialymst. Section Abstract Doc Link 15631309 Disease Relevance 0.16 Pain Relevance 0.20

Lithium was found to prevent the cannabis withdrawal syndrome (increased expression of Fos proteins in oxytocin-immunoreactive neurons and increased oxytocin mRNA expression / increased oxytocin levels in the peripheral blood).

Transcription (expression) of oxytocin in blood associated with cannabis and withdrawal

12) Confidence 0.07 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.50 Pain Relevance 0.91

General Comments

This test has worked.