INT7464

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2010
Negated 7
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 6.62
Pain Relevance 6.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
blood 4
heart 3
sympathetic 2
spleen 1
urine 1
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 5 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Ultiva 22 99.86 Very High Very High Very High
Action potential 3 99.62 Very High Very High Very High
antagonist 27 99.50 Very High Very High Very High
lidocaine 11 98.90 Very High Very High Very High
noradrenaline 15 98.78 Very High Very High Very High
anesthesia 50 98.70 Very High Very High Very High
tetrodotoxin 1 98.54 Very High Very High Very High
Clonidine 7 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 34 100.00 Very High Very High Very High
Sepsis 5 100.00 Very High Very High Very High
Stroke 5 100.00 Very High Very High Very High
Heart Rate Under Development 33 99.40 Very High Very High Very High
Sprains And Strains 6 99.28 Very High Very High Very High
Paralysis 2 99.24 Very High Very High Very High
Fever 1 98.84 Very High Very High Very High
Congenital Anomalies 7 97.84 Very High Very High Very High
Optic Neuritis 4 97.36 Very High Very High Very High
Hypertension 10 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The long-lasting pressor response to i.v. injected clonidine was abolished after water deprivation for 48 hr, whereas the initial rise in MBP was less affected.
Regulation (affected) of MBP associated with clonidine
1) Confidence 0.62 Published 1987 Journal Life Sci. Section Abstract Doc Link 3573988 Disease Relevance 0.07 Pain Relevance 0.58
By contrast, administration of 4% lidocaine (0.2-0.4 microliter) into the same HF sites failed to affect MBP and HR.
Neg (failed) Regulation (affect) of MBP associated with lidocaine
2) Confidence 0.59 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1349645 Disease Relevance 0.11 Pain Relevance 0.36
This change was blocked by tetrodotoxin, indicating that axonally generated action potentials were necessary to regulate the phosphorylation state of MBP.
Regulation (regulate) of MBP associated with action potential and tetrodotoxin
3) Confidence 0.39 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460230 Disease Relevance 0 Pain Relevance 0.34
Influence of SART stress on MBP and HR during the HUT test
Regulation (Influence) of MBP associated with stress
4) Confidence 0.27 Published 2010 Journal Biopsychosoc Med Section Body Doc Link PMC2967492 Disease Relevance 0.10 Pain Relevance 0
The results indicate that different mechanisms are involved in the effects of sepsis on MBP, sympathetic activation and fever.
Regulation (effects) of MBP in sympathetic associated with fever and sepsis
5) Confidence 0.25 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144036 Disease Relevance 0.97 Pain Relevance 0.20
Changes in resting MBP and HR after administration of phenylephrine were observed from 15 min to 105 min.
Regulation (Changes) of MBP
6) Confidence 0.24 Published 2010 Journal Biopsychosoc Med Section Body Doc Link PMC2967492 Disease Relevance 0 Pain Relevance 0.05
Time-related changes in MBP and HR with the HUT test are shown in Figure 1.
Regulation (changes) of MBP
7) Confidence 0.24 Published 2010 Journal Biopsychosoc Med Section Body Doc Link PMC2967492 Disease Relevance 0.10 Pain Relevance 0
There were no significant changes in intergroup mean blood pressure (MBP), but heart rate (HR) was higher and O2 saturation (SpO2) was lower in the pentazocine group after treatment.
Neg (no) Regulation (changes) of MBP in heart
8) Confidence 0.23 Published 2003 Journal Acta Anaesthesiol. Sin. Section Body Doc Link 12747344 Disease Relevance 0 Pain Relevance 0
Since the administration of BN 52021, at all doses studied, did not alter MBP and HR at the doses used, the bulk of these results clearly demonstrate a protective action of BN 52021, a specific antagonist of PAF, against bupivacaine-induced cardiovascular toxicity.
Neg (not) Regulation (alter) of MBP associated with toxicity and antagonist
9) Confidence 0.23 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2594614 Disease Relevance 0.16 Pain Relevance 0.12
Twelve beta adrenoceptor antagonists were examined for their effects on mean blood pressure (MBP), heart rate (HR), plasma renin activity (PRA) and sympathetic nerve function in spontaneously hypertensive rats (SHR).
Spec (examined) Regulation (effects) of MBP in sympathetic associated with antagonist and hypertension
10) Confidence 0.23 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2873238 Disease Relevance 0.17 Pain Relevance 0.19
The changes in HR and PRA were correlated with peripheral beta adrenoceptor blockade but changes in MBP were not.
Regulation (changes) of MBP
11) Confidence 0.23 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2873238 Disease Relevance 0.13 Pain Relevance 0.23
Changes in MBP and CI of nephrectomized, atropinized or intact rats did not differ significantly.
Regulation (Changes) of MBP
12) Confidence 0.23 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2936614 Disease Relevance 0.28 Pain Relevance 0
Pretreatment of the HF with the kappa opioid receptor antagonist nor-binaltorphimine at a dose of 2 to 4 nmol, which itself had no significant influence on basal MBP and HR, almost totally abolished the depressor and bradycardic responses induced by HF injection of DA1-8.
Neg (no) Regulation (influence) of MBP associated with antagonist and kappa opioid receptor
13) Confidence 0.22 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1349645 Disease Relevance 0.14 Pain Relevance 0.40
Noradrenaline in doses ranging from 0.03 to 0.3 micrograms (i.t.) did not alter the mean blood pressure (MBP) while higher doses (1, 3 and 10 micrograms, i.t.) caused a dose-dependent increase in MBP.
Neg (not) Regulation (alter) of MBP in blood associated with noradrenaline
14) Confidence 0.22 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8816361 Disease Relevance 0.24 Pain Relevance 0.27
We evaluated the effects of 10 microg i.c.v. cadmium on mean blood pressure (MBP) and several urinary parameters such as 24h urine volume, sodium and potassium excretion and osmolality in a rat strain inbred for low urinary kallikrein and in normal-kallikrein Wistar rats.
Regulation (effects) of MBP in urine associated with sprains and strains
15) Confidence 0.22 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12543064 Disease Relevance 0.10 Pain Relevance 0.08
Neither transfer magnitudes nor phases between ILV and MBP were affected during sevoflurane anesthesia.
Regulation (affected) of MBP
16) Confidence 0.22 Published 1999 Journal Can J Anaesth Section Body Doc Link 10490148 Disease Relevance 0 Pain Relevance 0
Percent changes in MBP, TPRI and CI were not different between SHR and WKY. 3.
Regulation (changes) of MBP
17) Confidence 0.22 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8542672 Disease Relevance 0.35 Pain Relevance 0
Comparative effects on heart rate (HR) and mean blood pressure (MBP) were also studied.
Regulation (effects) of MBP in blood
18) Confidence 0.20 Published 1997 Journal Brain Res. Section Abstract Doc Link 9401743 Disease Relevance 0.55 Pain Relevance 0.90
The combined treatment (flosequinan + xamoterol) significantly increased CO (1.7 l.min-1) and HR (10 beats.min-1), but had no effect on SV and MBP.
Neg (no) Regulation (effect) of MBP associated with heart rate under development
19) Confidence 0.19 Published 1994 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 7957523 Disease Relevance 0.77 Pain Relevance 0.16
Compared to placebo, at supine rest, flosequinan significantly increased heart rate (HR) by 5 beats.min-1, but had no effect on cardiac output (CO), stroke volume (SV) and mean blood pressure (MBP).
Neg (no) Regulation (effect) of MBP in blood associated with heart rate under development and stroke
20) Confidence 0.19 Published 1994 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 7957523 Disease Relevance 0.85 Pain Relevance 0.18

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