INT7465

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 53
Total Number 53
Disease Relevance 19.12
Pain Relevance 13.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
blood 6
plasma 2
heart 2
optic nerve 2
dendrites 1
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Metastatic pain 3 100.00 Very High Very High Very High
Morphine 5 99.98 Very High Very High Very High
MU agonist 3 99.80 Very High Very High Very High
antagonist 47 99.72 Very High Very High Very High
intrathecal 5 99.72 Very High Very High Very High
Spinal cord 31 99.56 Very High Very High Very High
corticosteroid 1 99.52 Very High Very High Very High
substance P 14 99.48 Very High Very High Very High
lidocaine 21 99.40 Very High Very High Very High
agonist 20 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Hypertension 26 99.84 Very High Very High Very High
Hypotension 37 99.76 Very High Very High Very High
Disease 72 99.16 Very High Very High Very High
Ganglion Cysts 52 99.00 Very High Very High Very High
Multiple Sclerosis 138 98.86 Very High Very High Very High
Demyelinating Disease 18 98.74 Very High Very High Very High
Death 20 98.68 Very High Very High Very High
INFLAMMATION 50 97.92 Very High Very High Very High
Schizophrenia 220 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreases in MBP and DBP were persistent after 60 minutes.
Negative_regulation (decreases) of MBP
1) Confidence 0.58 Published 1989 Journal Reg Anesth Section Abstract Doc Link 2487666 Disease Relevance 0.47 Pain Relevance 0.34
Intravenous injection of the specific platelet-activating factor (PAF) antagonist BN 52021 (10 mg/kg), 30 min before bupivacaine administration (2 mg/kg i.v.) suppressed both the decrease of MBP and HR.
Negative_regulation (decrease) of MBP in platelet associated with antagonist
2) Confidence 0.57 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2594614 Disease Relevance 0.09 Pain Relevance 0.09
Significant attenuation of MBP and HR was observed in the lidocaine and ketamine-lidocaine groups (P < .05).
Negative_regulation (attenuation) of MBP associated with ketamine and lidocaine
3) Confidence 0.56 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11426091 Disease Relevance 0 Pain Relevance 1.36
Hypoxic-ischemic insults resulted in severe white matter injury, enlarged ventricles, deficits in the hippocampus, reduction in numbers of mature oligodendrocytes and tyrosine hydroxylase-positive neurons, damage to axons and dendrites, and impaired myelination, as indicated by the decrease in myelin basic protein immunostaining in the P21 rat brain.
Negative_regulation (decrease) of myelin basic protein in dendrites associated with hypoxia, injury and hippocampus
4) Confidence 0.56 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836639 Disease Relevance 1.55 Pain Relevance 0.39
The maximal decrease in MBP and AUC due to tilting in the stressed rats was 24.3 ± 2.1 mmHg and 68.9 ± 6.8 mmHg·min, respectively, significantly higher than the values for unstressed rats (l7.3 ± 1.0 mmHg and 25.5 ± 1.9 mmHg·min, respectively).
Negative_regulation (decrease) of MBP
5) Confidence 0.51 Published 2010 Journal Biopsychosoc Med Section Body Doc Link PMC2967492 Disease Relevance 0 Pain Relevance 0.03
In anesthetized rats, RU 486 pretreatment decreases MBP, increases cardiac output (radiolabelled microsphere method), and depresses total and renal vascular resistance.
Negative_regulation (decreases) of MBP
6) Confidence 0.51 Published 1987 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 3116979 Disease Relevance 0 Pain Relevance 0.04
LPS administration resulted in severe white matter injury, enlarged ventricles, deficits in the hippocampus, loss of oligodendrocytes and tyrosine hydroxylase neurons, damage to axons and dendrites, and impaired myelination as indicated by the decrease in myelin basic protein immunostaining in the P21 rat brain.
Negative_regulation (decrease) of myelin basic protein in neurons associated with injury and hippocampus
7) Confidence 0.50 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16118791 Disease Relevance 0.64 Pain Relevance 0.29
LPS exposure resulted in severe brain damage, including enlargement of ventricles bilaterally, loss of mature oligodendrocytes, impaired myelination as indicated by the decrease in myelin basic protein immunostaining, and alterations in dendritic processes in the cortical gray matter of the parietal cortex.
Negative_regulation (decrease) of myelin basic protein in oligodendrocytes
8) Confidence 0.50 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18683243 Disease Relevance 0.29 Pain Relevance 0.16
Also, the rotenone exposure for 2 months resulted in a reduction of myelin basic protein (MBP) in the optic nerve by approximately 20% of control (Figure 4).
Negative_regulation (reduction) of myelin basic protein in optic nerve
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900204 Disease Relevance 0.21 Pain Relevance 0
Also, the rotenone exposure for 2 months resulted in a reduction of myelin basic protein (MBP) in the optic nerve by approximately 20% of control (Figure 4).
Negative_regulation (reduction) of MBP in optic nerve
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900204 Disease Relevance 0.21 Pain Relevance 0
Second, the decreases in MBP and HR were well tolerated by the healthy, well-hydrated patients of our study.
Negative_regulation (decreases) of MBP
11) Confidence 0.49 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2926435 Disease Relevance 0.33 Pain Relevance 0.45
Furthermore, the reduction in MBP caused by beta adrenoceptor antagonists is unrelated to acute beta adrenoceptor blockade, changes in HR, reductions in PRA or inhibition of sympathetic nerve function.
Negative_regulation (reduction) of MBP in sympathetic associated with antagonist
12) Confidence 0.49 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2873238 Disease Relevance 0.07 Pain Relevance 0.24
This reduction in MBP was dissociable from both reductions in HR as well as peripheral beta adrenoceptor blockade.
Negative_regulation (reduction) of MBP
13) Confidence 0.49 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2873238 Disease Relevance 0.16 Pain Relevance 0.22
In the hypotensive patients a decrease in MBP from 108 +/- 3 to 94 +/- 3 mmHg was accompanied by a simultaneous increase in HR from 81 +/- 3 to 91 +/- 3 beats/min (P less than 0.05).
Negative_regulation (decrease) of MBP associated with hypotension
14) Confidence 0.49 Published 1986 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3811794 Disease Relevance 0.43 Pain Relevance 0.08
An inotropic agent was given if the patient's MBP dropped below 65 mmHg or if the patient experienced a decrease in MBP greater than 20% of the preinduction value.
Negative_regulation (decrease) of MBP
15) Confidence 0.48 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 17972615 Disease Relevance 0 Pain Relevance 0
In anesthetized goats, IC injections of SP (1 to 6 micrograms.kg-1) reduced phrenic activity and MBP before and after CBX.
Negative_regulation (reduced) of MBP in phrenic associated with substance p
16) Confidence 0.47 Published 1995 Journal Respir Physiol Section Abstract Doc Link 8525117 Disease Relevance 0.23 Pain Relevance 0.60
LPS administration induced profound increases in RSNA and decreases in MBP.
Negative_regulation (decreases) of MBP
17) Confidence 0.47 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144036 Disease Relevance 0.65 Pain Relevance 0.28
Disease suppression was associated with a marked suppression of MBP-specific T-cell reactivity in vitro, without any evidence for a generalized impairment of T-cell activity.
Negative_regulation (suppression) of MBP in T-cell associated with disease
18) Confidence 0.43 Published 2005 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 16114509 Disease Relevance 0.83 Pain Relevance 0.24
Intravenous injection of BLF produced dose-dependent decreases in MBP but did not affect HR, while the opioid agonist morphine decreased both MBP and HR.
Negative_regulation (decreases) of MBP associated with mu agonist and morphine
19) Confidence 0.43 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14563657 Disease Relevance 0.38 Pain Relevance 0.35
KEY RESULTS: In anaesthetized rats, anandamide (1.5-3 micromol.kg(-1)) and its stable analogue methanandamide (0.5 micromol.kg(-1)) caused a delayed and prolonged decrease in MBP, SBP, DBP, MBF and RBF by about 10-30% of the respective basal values without changing HR.
Negative_regulation (decrease) of MBP
20) Confidence 0.43 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20105178 Disease Relevance 0.08 Pain Relevance 0

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