INT7468

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2008
Negated 0
Speculated 7
Reported most in Abstract
Documents 109
Total Number 116
Disease Relevance 9.46
Pain Relevance 66.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
neurohypophysis 31
plasma 17
neural lobe 14
neurons 8
tail 4
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 253 100.00 Very High Very High Very High
Opioid 141 100.00 Very High Very High Very High
Enkephalin 58 100.00 Very High Very High Very High
Dopamine 58 100.00 Very High Very High Very High
noradrenaline 41 100.00 Very High Very High Very High
Cholecystokinin 21 100.00 Very High Very High Very High
Nucleus accumbens 1 100.00 Very High Very High Very High
Endogenous opioid 104 99.98 Very High Very High Very High
Morphine 94 99.98 Very High Very High Very High
opiate 68 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 22 100.00 Very High Very High Very High
Hyperalgesia 3 99.92 Very High Very High Very High
Volume Depletion And Dehydration 27 98.88 Very High Very High Very High
Pressure Volume 2 Under Development 13 97.84 Very High Very High Very High
Hypertension 12 97.00 Very High Very High Very High
Hemorrhage 15 96.68 Very High Very High Very High
Urological Neuroanatomy 9 95.72 Very High Very High Very High
Premature Birth 2 88.80 High High
Hyperphagia 3 87.36 High High
Vomiting 1 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pethidine (meperidine) inhibition of oxytocin secretion and action in parturient rats.
Negative_regulation (inhibition) of Localization (secretion) of oxytocin associated with algil
1) Confidence 0.59 Published 1991 Journal Am. J. Physiol. Section Title Doc Link 1877695 Disease Relevance 0 Pain Relevance 0.93
Injection of the opiate antagonist naloxone counteracted the inhibition of oxytocin secretion and largely prevented the slowing of parturition.
Negative_regulation (inhibition) of Localization (secretion) of oxytocin associated with antagonist, narcan and opiate
2) Confidence 0.59 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1877695 Disease Relevance 0 Pain Relevance 0.79
This observation indicates liberation of an endogenous opioid, during stimulation of the neurohypophysis, leading to inhibition of the oxytocin secretion.
Negative_regulation (inhibition) of Localization (secretion) of oxytocin in neurohypophysis associated with endogenous opioid
3) Confidence 0.59 Published 1988 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2848232 Disease Relevance 0.09 Pain Relevance 0.69
They are unlikely to be of neurohypophysial origin and may probably come from the adrenal medulla, since acute adrenalectomy negated the inhibitory effect of relaxin on oxytocin release.
Negative_regulation (effect) of Localization (release) of oxytocin in adrenal medulla associated with medulla
4) Confidence 0.59 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.36
Thus pethidine inhibits oxytocin secretion in all three conditions; this inhibition is probably mediated by central opioid receptors.
Negative_regulation (inhibits) of Localization (secretion) of oxytocin associated with algil and opioid receptor
5) Confidence 0.59 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1877695 Disease Relevance 0 Pain Relevance 0.98
To test whether the opiates from the intermediate lobe inhibit the release of oxytocin, we performed similar experiments on the isolated neural lobe, after almost total removal of intermediate lobe tissue.
Spec (whether) Negative_regulation (inhibit) of Localization (release) of oxytocin in lobe associated with opiate
6) Confidence 0.59 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6324042 Disease Relevance 0 Pain Relevance 0.49
An endogenous opioid regulatory mechanism inhibiting oxytocin secretion becomes activated immediately prior to and during parturition.
Negative_regulation (inhibiting) of Localization (secretion) of oxytocin associated with endogenous opioid
7) Confidence 0.59 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 2842005 Disease Relevance 0 Pain Relevance 0.75
Accordingly, in late pregnant rats, oxytocin neurons are restrained from premature activation and stimulated oxytocin secretion is inhibited, preserving the expanded neurohypophysial oxytocin stores for parturition.
Negative_regulation (inhibited) of Localization (secretion) of oxytocin in neurons
8) Confidence 0.59 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.15 Pain Relevance 0.11
The potentiating effect of naloxone upon oxytocin release was undiminished, suggesting that the endogenous opiate responsible for inhibiting oxytocin secretion comes from the neural lobe itself.
Negative_regulation (inhibiting) of Localization (secretion) of oxytocin in neural lobe associated with narcan and opiate
9) Confidence 0.59 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6324042 Disease Relevance 0 Pain Relevance 0.48
Oxytocin release is inhibited by opiates from the neural lobe, not those from the intermediate lobe.
Negative_regulation (inhibited) of Localization (release) of Oxytocin in neural lobe associated with opiate
10) Confidence 0.59 Published 1983 Journal Neurosci. Lett. Section Title Doc Link 6324042 Disease Relevance 0 Pain Relevance 0.48
The results suggest that, following an i.p. injection of hypertonic saline, endogenous opioids act at the neurosecretory terminals to partially inhibit oxytocin release.
Negative_regulation (inhibit) of Localization (release) of oxytocin associated with endogenous opioid
11) Confidence 0.59 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3399134 Disease Relevance 0 Pain Relevance 0.18
Experiments were carried out to establish whether infusion of relaxin prolongs gestation and labour in the rat by suppressing release of oxytocin, and whether the effects of relaxin on birth could be reversed by the opioid antagonist naloxone.
Spec (whether) Negative_regulation (suppressing) of Localization (release) of oxytocin associated with antagonist, narcan and opioid
12) Confidence 0.59 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3783086 Disease Relevance 0 Pain Relevance 0.23
Thus our hypothesis is that stress activates opioid pathways which delay parturition by inhibiting oxytocin release.
Negative_regulation (inhibiting) of Localization (release) of oxytocin associated with stress and opioid
13) Confidence 0.58 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 3655612 Disease Relevance 0.17 Pain Relevance 0.45
Interruption of parturition in rats by morphine: a result of inhibition of oxytocin secretion.
Negative_regulation (inhibition) of Localization (secretion) of oxytocin associated with narcan and morphine
14) Confidence 0.58 Published 1989 Journal J. Endocrinol. Section Title Doc Link 2754376 Disease Relevance 0 Pain Relevance 1.26
It is concluded that morphine given during parturition acts centrally through opioid receptors to inhibit oxytocin secretion, and impairs the expression of maternal behaviour.
Negative_regulation (inhibit) of Localization (secretion) of oxytocin associated with opioid receptor and morphine
15) Confidence 0.58 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2754376 Disease Relevance 0 Pain Relevance 0.90
Oxytocin secretion is inhibited by opioids, and oxytocin is important in parturition.
Negative_regulation (inhibited) of Localization (secretion) of Oxytocin associated with opioid
16) Confidence 0.58 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2754376 Disease Relevance 0 Pain Relevance 0.78
Opioid receptors in the neurohypophysis are predominantly of the kappa-subtype and selective kappa-agonists suppress electrically evoked release of oxytocin (OXT) and vasopressin (AVP).
Negative_regulation (suppress) of Localization (release) of oxytocin in neurohypophysis associated with agonist and opioid receptor
17) Confidence 0.58 Published 1988 Journal Brain Res. Section Abstract Doc Link 2902908 Disease Relevance 0 Pain Relevance 0.39
However morphine blocked oxytocin release into blood indicative of a central inhibitory action on the firing rate of oxytocin neurones, contrasted with insensitivity to morphine of oxytocin secretion from the dendrites stimulated directly by hyperosmolarity.
Negative_regulation (blocked) of Localization (release) of oxytocin in blood associated with morphine
18) Confidence 0.58 Published 1994 Journal Neuropeptides Section Abstract Doc Link 7991066 Disease Relevance 0 Pain Relevance 0.62
This was in accordance with the bremazocine inhibition of oxytocin release after submaximal electrical stimulation seen in isolated neurointermediate lobes.
Negative_regulation (inhibition) of Localization (release) of oxytocin in lobes
19) Confidence 0.58 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.19
The biphasic time course of the plasma oxytocin response can be explained by a combination of an inhibition of oxytocin release from the neurohypophysis and an increased water excretion leading to an elevation in plasma sodium, which may be responsible for the late rise in plasma oxytocin.
Negative_regulation (inhibition) of Localization (release) of oxytocin in plasma
20) Confidence 0.58 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.19

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