INT74680

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Context Info
Confidence 0.23
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.33
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
sciatic nerve 1
lung 1
Mmp12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 99.30 Very High Very High Very High
Inflammation 39 98.72 Very High Very High Very High
metalloproteinase 18 90.56 High High
Neuritis 11 89.20 High High
corticosteroid 1 84.40 Quite High
cytokine 10 78.44 Quite High
cINOD 9 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aneurism 21 99.00 Very High Very High Very High
INFLAMMATION 51 98.72 Very High Very High Very High
Nicotine Addiction 10 97.88 Very High Very High Very High
Pulmonary Disease 55 96.84 Very High Very High Very High
Disease 21 92.12 High High
Abdominal Aortic Aneurysm 3 90.08 High High
Experimental Autoimmune Neuritis 11 89.20 High High
Rupture 1 72.48 Quite High
Emphysema 8 72.00 Quite High
Atherosclerosis 4 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prominent infiltration of inflammatory cells into the sciatic nerve was concordant with a significant increase in the expression levels of matrilysin and macrophage metalloelastase.
Positive_regulation (increase) of macrophage metalloelastase in sciatic nerve associated with inflammation and sciatic nerve
1) Confidence 0.23 Published 1998 Journal Brain Section Abstract Doc Link 9549524 Disease Relevance 1.03 Pain Relevance 0.85
The proposed role of macrophage derived MMP12 in the emphysematous changes to the lung in chronic smoking models in mice (Shapiro et al 2003) would suggest that PDE4 inhibitors will be ineffective at inhibiting emphysematous changes to the lung.
Positive_regulation (derived) of MMP12 in lung associated with nicotine addiction
2) Confidence 0.15 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.51 Pain Relevance 0.05
Increased levels of MMP-2, MMP-3, MMP-9 and MMP-12 have been identified in aneurysm vessel walls [23-27].
Positive_regulation (Increased) of MMP-12 associated with aneurism
3) Confidence 0.05 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.79 Pain Relevance 0.26

General Comments

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