INT74681

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 15.58
Pain Relevance 10.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
stellate cells 4
neutrophils 3
epithelial cells 2
endometrium 2
tear 2
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 588 100.00 Very High Very High Very High
cytokine 60 100.00 Very High Very High Very High
chemokine 14 100.00 Very High Very High Very High
Angina 5 99.84 Very High Very High Very High
fibrosis 192 99.72 Very High Very High Very High
Neuritis 11 98.84 Very High Very High Very High
Dismenorea 10 98.44 Very High Very High Very High
Inflammation 138 95.60 Very High Very High Very High
alcohol 15 92.96 High High
ischemia 169 92.76 High High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 88 99.96 Very High Very High Very High
Cv General 3 Under Development 5 99.84 Very High Very High Very High
Reperfusion Injury 196 99.62 Very High Very High Very High
Myocardial Infarction 9 99.44 Very High Very High Very High
Experimental Autoimmune Neuritis 11 98.84 Very High Very High Very High
Pulmonary Hypertension 35 98.56 Very High Very High Very High
Bronchopulmonary Dysplasia 122 98.52 Very High Very High Very High
Dysmenorrhea 10 98.44 Very High Very High Very High
Endometriosis (extended) 11 98.40 Very High Very High Very High
Fibrosis 126 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zhou et al found increased MMP2 expression and activity in their ?
Positive_regulation (increased) of Gene_expression (expression) of MMP2
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.49 Pain Relevance 0.18
CONCLUSION: This study provides preliminary evidence that topical application of some NSAIDs can induce the early expression of MMP-1, MMP-2, and MMP-8 in the cornea, suggesting that MMPs play a role in the corneal cytotoxicity of certain NSAIDs.


Positive_regulation (induce) of Gene_expression (expression) of MMP-2 in cornea
2) Confidence 0.41 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
The pattern of change in the activated MMP2 fraction differed significantly according to BPD status, with lower levels at birth in BDP infants, followed by a steep increase during the first days of life (p?
Positive_regulation (activated) of Gene_expression (fraction) of MMP2 associated with bronchopulmonary dysplasia
3) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.62 Pain Relevance 0
A significant association was found between polymorphisms in the MMP16 gene and the activated MMP2 fraction in second samples, but not in first samples (day 0) (Figure 1).
Neg (not) Positive_regulation (activated) of Gene_expression (fraction) of MMP2
4) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.49 Pain Relevance 0
Although there was no statistically significant difference in the expression between the MMP-2 and MMP-9, MMP-2 appeared to be expressed at a higher level on the 4th day, compared to MMP-9 and also showed a tendency to decline less rapidly (Fig. 5).


Positive_regulation (level) of Gene_expression (expressed) of MMP-2 associated with metalloproteinase
5) Confidence 0.40 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.28 Pain Relevance 0.68
The overall expression of MMP-2 and MMP-9 along the time sequence dynamically changed according to the immunohistochemical score.
Positive_regulation (changed) of Gene_expression (expression) of MMP-2 associated with metalloproteinase
6) Confidence 0.40 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.48 Pain Relevance 0.70
TGF-beta 1, the most potent fibrogenic cytokine, has been reported to increase in pulmonary fibrosis and to be expressed in alveolar epithelial cells in higher levels even in later phase of pulmonary fibrosis.37,38 It was also reported that TGF-beta 1 induces transition of alveolar epithelial cells to mesenchymal/fibroblasts-like cells and MMP-2 expression in those cells,39 possibly suggesting that MMP-2 production in alveolar epithelial cells by TGF-beta 1 may promote pulmonary fibrosis.
Positive_regulation (promote) of Gene_expression (production) of MMP-2 in epithelial cells associated with fibrosis, metalloproteinase, pulmonary fibrosis and cytokine
7) Confidence 0.40 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.72 Pain Relevance 1.05
During hepatic fibrogenesis, MMPs involved in fibrillar collagen degradation are down-regulated, whereas the expression of MMP-2 is markedly increased (12).
Positive_regulation (increased) of Gene_expression (expression) of MMP-2 associated with fibrosis and metalloproteinase
8) Confidence 0.38 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.35 Pain Relevance 0.42
Furthermore, the upregulation of MMP-2 expression in the basal ganglia of piglets 6 h after hypoxia-resuscitation has also been reported [16], but there were no significant differences between the reoxygenated groups.
Positive_regulation (upregulation) of Gene_expression (expression) of MMP-2 in basal ganglia associated with hypoxia
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.22 Pain Relevance 0.09
Our study provides preliminary evidence that topical application of fluoroquinolone drugs can induce the expression of MMP-1, MMP-2, MMP-8 and MMP-9 in the undebrided corneal epithelium compared to artificial tear eye drops.



Positive_regulation (induce) of Gene_expression (expression) of MMP-2 in tear
10) Confidence 0.24 Published 2003 Journal BMC Ophthalmol Section Abstract Doc Link PMC239861 Disease Relevance 0.09 Pain Relevance 0.23
In vivo, MMP-2 expression increased in astrocytic endfeet of rats exposed to MCAO, while MMP-9 expression was localized to neutrophils and endothelial cells [22].
Positive_regulation (increased) of Gene_expression (expression) of MMP-2 in neutrophils
11) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.55 Pain Relevance 0.42
Eutopic endometrium from controls in the proliferative phase showed significantly increased expressions of MMP-2 mRNA compared with that in the secretory phase (P < 0.05).
Positive_regulation (increased) of Gene_expression (expressions) of MMP-2 mRNA in endometrium
12) Confidence 0.19 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.10 Pain Relevance 0
Compared with control-fed C+CsA+Cer rats, their ethanol-fed E+CsA+Cer counterparts showed marked increases in pancreatic NF-kappaB activation and cytokine/chemokine mRNA expression, collagen and fibronectin, the expression and activities of matrix metalloproteinase-2 and -9, and activation of pancreatic stellate cells.
Positive_regulation (activation) of Gene_expression (expression) of matrix metalloproteinase-2 in stellate cells associated with chemokine, metalloproteinase and cytokine
13) Confidence 0.17 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17884979 Disease Relevance 1.22 Pain Relevance 0.96
Compared with control-fed C+CsA+Cer rats, their ethanol-fed E+CsA+Cer counterparts showed marked increases in pancreatic NF-kappaB activation and cytokine/chemokine mRNA expression, collagen and fibronectin, the expression and activities of matrix metalloproteinase-2 and -9, and activation of pancreatic stellate cells.
Positive_regulation (increases) of Gene_expression (expression) of matrix metalloproteinase-2 in stellate cells associated with chemokine, metalloproteinase and cytokine
14) Confidence 0.17 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17884979 Disease Relevance 1.24 Pain Relevance 0.97
Expression levels of 92 kDa gelatinase and stromelysin-1 were significantly increased early in the development of EAN and continued to rise, peaking at day 15 coincident with maximum disease severity.
Positive_regulation (increased) of Gene_expression (Expression) of gelatinase associated with disease and neuritis
15) Confidence 0.15 Published 1998 Journal Brain Section Abstract Doc Link 9549524 Disease Relevance 1.39 Pain Relevance 1.08
Our group and others have previously demonstrated an increased expression of gelatinases, MMP 2 and MMP 9 in monocrotaline induced pulmonary hypertension [5,11].
Positive_regulation (increased) of Gene_expression (expression) of MMP 2 associated with pulmonary hypertension
16) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.32 Pain Relevance 0.03
Yano et al demonstrated that LIRI resulted in MMP-9 induction, but not MMP-2 expression 24 hours after LIRI [45].
Positive_regulation (induction) of Gene_expression (expression) of MMP-2 associated with reperfusion injury and metalloproteinase
17) Confidence 0.12 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 1.03 Pain Relevance 0.50
Nevertheless, we found that levels of both pro- and active MMP-9 and MMP-2 per microliter BALf are elevated 24 hours after LIRI, which correlates well with the presence of neutrophils in left lung BALf.
Positive_regulation (elevated) of Gene_expression (levels) of MMP-2 in left lung associated with reperfusion injury and metalloproteinase
18) Confidence 0.11 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 1.10 Pain Relevance 0.49
Gene expressions of prolyl hydroxylase and tissue inhibitors of matrix metalloproteinase-2 were elevated.
Positive_regulation (elevated) of Gene_expression (expressions) of matrix metalloproteinase-2 associated with metalloproteinase
19) Confidence 0.11 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17616939 Disease Relevance 0.71 Pain Relevance 0.47
Increased levels of MMP-2 have been noted after transplantation of human umbilical cord blood stem cells(UCBSCs) in rats leading to a decrease in the glial scar size; however, the underlying mechanism is not yet clear.


Positive_regulation (Increased) of Gene_expression (levels) of MMP-2 in stem cells associated with cicatrix and metalloproteinase
20) Confidence 0.10 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 1.05 Pain Relevance 0.33

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