INT74682

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 72
Total Number 72
Disease Relevance 40.46
Pain Relevance 21.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
lung 6
brain 3
liver 3
vessels 2
hippocampus 1
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 1583 100.00 Very High Very High Very High
cytokine 171 100.00 Very High Very High Very High
Nerve growth factor 54 100.00 Very High Very High Very High
fibrosis 538 99.68 Very High Very High Very High
Angina 6 99.64 Very High Very High Very High
ischemia 171 99.56 Very High Very High Very High
Hyperalgesia 4 99.56 Very High Very High Very High
antidepressant 18 99.34 Very High Very High Very High
Hippocampus 51 99.32 Very High Very High Very High
Inflammation 374 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 74 99.96 Very High Very High Very High
Coronary Heart Disease 49 99.96 Very High Very High Very High
Injury 350 99.88 Very High Very High Very High
Bronchopulmonary Dysplasia 732 99.84 Very High Very High Very High
Reperfusion Injury 301 99.84 Very High Very High Very High
Pulmonary Fibrosis 223 99.68 Very High Very High Very High
Ureteral Obstruction 4 99.66 Very High Very High Very High
Pulmonary Disease 70 99.64 Very High Very High Very High
Cv General 3 Under Development 15 99.64 Very High Very High Very High
Pituitary Cancer 11 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that acute and chronic ECS differentially regulate the transcript levels of MMP-2/9 and TIMPs 1-4 and also increase gelatinase activity in the hippocampus.
Positive_regulation (increase) of gelatinase in hippocampus associated with hippocampus
1) Confidence 0.69 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.14 Pain Relevance 0.80
CONCLUSIONS: Our findings indicate that a long-term increase in gelatinolytic activity of active MMP-2 in Arg-induced pancreatitis causes continuous disorganization of type IV collagen in the BM and progressive acinar atrophy, whereas a transient increase in gelatinolytic activity of active MMP-2 is involved in the regeneration of type IV collagen structure in the BM and recovery from acinar injury.


Positive_regulation (increase) of MMP-2
2) Confidence 0.64 Published 2005 Journal Pancreas Section Body Doc Link 16258372 Disease Relevance 0 Pain Relevance 0
It was expected that the active forms of MMP-2 and MMP-9 might have been increased in the early phase of pulmonary fibrosis when the total MMP-2 and MMP-9 activity reached the maximum.
Positive_regulation (increased) of MMP-2 associated with fibrosis, metalloproteinase and pulmonary fibrosis
3) Confidence 0.55 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.42 Pain Relevance 1.04
They are also in keeping with the early increase in the active MMP2 fraction previously observed in the lungs of newborn rats exposed to hyperoxia [21].
Positive_regulation (increase) of MMP2 in lungs associated with hyperoxia
4) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.93 Pain Relevance 0
Given the hippocampal structural remodeling associated with antidepressant treatments, we hypothesized that antidepressants may regulate the expression and activity of MMP-2/9 and TIMPs 1-4.
Positive_regulation (activity) of MMP-2 associated with antidepressant
5) Confidence 0.46 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.17 Pain Relevance 0.70
Naltrexone treatment in BDL rats led to a decrease in the level of liver MMP-2 activity, which had already increased during cholestasis.
Positive_regulation (increased) of MMP-2 in liver
6) Confidence 0.46 Published 2007 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17295775 Disease Relevance 0.14 Pain Relevance 0
CONCLUSIONS: Our findings indicate that a long-term increase in gelatinolytic activity of active MMP-2 in Arg-induced pancreatitis causes continuous disorganization of type IV collagen in the BM and progressive acinar atrophy, whereas a transient increase in gelatinolytic activity of active MMP-2 is involved in the regeneration of type IV collagen structure in the BM and recovery from acinar injury.


Positive_regulation (increase) of MMP-2
7) Confidence 0.43 Published 2005 Journal Pancreas Section Body Doc Link 16258372 Disease Relevance 0 Pain Relevance 0
The corneas were excised and processed for immunohistochemical staining, Western blot assay, and zymography studies to determine the localization of the production of the following matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-8, and MMP-9.
Positive_regulation (following) of MMP-2 in corneas
8) Confidence 0.41 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.06 Pain Relevance 0
However, second samples had significantly higher MMP2 contents and higher levels of activated MMP2 in BPD infants.
Positive_regulation (activated) of MMP2 associated with bronchopulmonary dysplasia
9) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.68 Pain Relevance 0
The MMP16 genotype also influenced the size of the activated MMP2 fraction in the infants' tracheal aspirates.
Positive_regulation (activated) of MMP2
10) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.87 Pain Relevance 0.09
The functional domains of MMP16 and MMP14 are not interchangeable for pro-MMP2 activation and collagenolysis, despite their similarities [28].
Positive_regulation (activation) of MMP2
11) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.12 Pain Relevance 0.03
Despite increases in MMP-2 protein levels in diabetic rats, there was no difference in MMP-2 activity between control and GK rats.
Positive_regulation (increases) of MMP-2 associated with diabetes mellitus and metalloproteinase
12) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.81 Pain Relevance 0.59
Another study reported increased MMP-2 and MMP-9 activity and rapid degradation of occludin after temporary focal ischemia (38).
Positive_regulation (increased) of MMP-2 associated with ischemia and metalloproteinase
13) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.89 Pain Relevance 0.19
This peak is marked by the increase in active soluble 17 kDa TNF-alpha and by gelatinase A (MMP-2) upregulation.
Positive_regulation (upregulation) of MMP-2
14) Confidence 0.39 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650133 Disease Relevance 0.93 Pain Relevance 0.83
Gelatinolytic activity of active MMP-2 increased significantly from day 13 to day 40 after the first intraperitoneal Arg injection, whereas it decreased to the baseline level on day 35 after the first intraperitoneal Cn injection and on day 42 after intraductal infusion of NaTc.
Positive_regulation (increased) of MMP-2
15) Confidence 0.37 Published 2005 Journal Pancreas Section Body Doc Link 16258372 Disease Relevance 0.05 Pain Relevance 0
In keeping with our observation that BPD was associated with an elevated active fraction of MMP2, the MMP16 genotypes associated with a lower risk of BPD, i.e.
Positive_regulation (elevated) of MMP2 associated with bronchopulmonary dysplasia
16) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.61 Pain Relevance 0
The fraction of activated gelatinase was calculated as the activated/total enzyme ratio.


Positive_regulation (activated) of gelatinase
17) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0 Pain Relevance 0
MMP2 has also been implicated in the pathogenesis of BPD [5], [6].
Positive_regulation (implicated) of MMP2 associated with bronchopulmonary dysplasia
18) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 1.09 Pain Relevance 0
Type I transmembrane MT-MMPs participate in the activation of the zymogen form of MMP2 (pro-MMP2).
Positive_regulation (activation) of MMP2 associated with metalloproteinase
19) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.45 Pain Relevance 0.30
Inflammation after epithelial injury is believed to be the integral part of the pathophysiology of pulmonary fibrosis,16 especially in early phase, although the links between fibrosis and inflammation have been debated.17-19 Dysregulated wound repair is also believed to be important pathogenetic mechanisms.18,19 Key players, such as TGF-beta 1, TNF, and IL-1 beta have been reported to be crucial in sustaining inflammation and promoting progressive fibrosis.10,20,21 MMPs and their inhibitors, TIMPs, have been known to play important roles in pulmonary fibrosis through their function in matrix protein degradation and its control.3-5 Among many types of MMPs, MMP-2 and MMP-9 have been known to be important and to show increased activity in many pulmonary diseases including pulmonary fibrosis.4,5,22,23 Herein, we demonstrated that the activity of MMP-2 and MMP-9 in the bronchoalveolar lavage fluid and lung parenchyma increased rapidly in the early phase, reaching the peak levels on the 4th day, and then consistently decreased thereafter.
Positive_regulation (increased) of MMP-2 in parenchyma associated with fibrosis, pulmonary disease, inflammation, injury, metalloproteinase and pulmonary fibrosis
20) Confidence 0.37 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 1.11 Pain Relevance 0.87

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