INT74683

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Context Info
Confidence 0.23
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
sciatic nerve 2
Mmp12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 19 100.00 Very High Very High Very High
Sciatic nerve 2 99.30 Very High Very High Very High
Inflammation 30 98.72 Very High Very High Very High
chemokine 3 90.20 High High
Neuritis 11 89.20 High High
cytokine 12 88.44 High High
corticosteroid 1 84.40 Quite High
Potency 1 62.56 Quite High
Arthritis 4 51.52 Quite High
Osteoarthritis 23 35.16 Quite Low
Disease Link Frequency Relevance Heat
Aneurism 21 99.00 Very High Very High Very High
INFLAMMATION 33 98.72 Very High Very High Very High
Disease 4 92.12 High High
Abdominal Aortic Aneurysm 3 90.08 High High
Experimental Autoimmune Neuritis 11 89.20 High High
Rupture 1 72.48 Quite High
Atherosclerosis 4 61.60 Quite High
Necrosis 2 59.12 Quite High
Cancer 3 58.76 Quite High
Arthritis 11 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prominent infiltration of inflammatory cells into the sciatic nerve was concordant with a significant increase in the expression levels of matrilysin and macrophage metalloelastase.
Positive_regulation (increase) of Gene_expression (expression) of macrophage metalloelastase in sciatic nerve associated with inflammation and sciatic nerve
1) Confidence 0.23 Published 1998 Journal Brain Section Abstract Doc Link 9549524 Disease Relevance 1.03 Pain Relevance 0.85
By increasing the expression of matrix metalloproteinases (MMP-3, MMP-9, MMP-10, MMP-12, and MMP-13) while inhibiting the expression of genes encoding essential components of the ECM (such as collagen type II and aggrecan-1), the elevated IL-1?
Positive_regulation (increasing) of Gene_expression (expression) of MMP-12 associated with metalloproteinase
2) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.20 Pain Relevance 0.30
Increased levels of MMP-2, MMP-3, MMP-9 and MMP-12 have been identified in aneurysm vessel walls [23-27].
Positive_regulation (Increased) of Gene_expression (levels) of MMP-12 associated with aneurism
3) Confidence 0.05 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.79 Pain Relevance 0.26

General Comments

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