INT74684

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.69
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
macrophages 1
sciatic nerve 1
alveolar macrophages 1
T lymphocytes 1
Mmp12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 40 100.00 Very High Very High Very High
Sciatic nerve 6 98.98 Very High Very High Very High
Inflammation 84 98.40 Very High Very High Very High
chemokine 9 94.76 High High
cytokine 30 94.28 High High
Neuritis 33 90.48 High High
corticosteroid 1 84.00 Quite High
Osteoarthritis 46 78.72 Quite High
fibrosis 11 62.56 Quite High
Potency 3 62.56 Quite High
Disease Link Frequency Relevance Heat
Aneurism 21 99.00 Very High Very High Very High
INFLAMMATION 99 98.40 Very High Very High Very High
Pulmonary Disease 69 97.20 Very High Very High Very High
Emphysema 9 95.36 Very High Very High Very High
Disease 43 91.48 High High
Experimental Autoimmune Neuritis 33 90.48 High High
Abdominal Aortic Aneurysm 3 90.08 High High
Hypertrophy 2 89.28 High High
Arthritis 22 88.88 High High
Hyperplasia 1 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both matrilysin and macrophage metalloelastase were detected in invading macrophages, T lymphocytes and resident Schwann cells.
Gene_expression (detected) of macrophage metalloelastase in macrophages
1) Confidence 0.31 Published 1998 Journal Brain Section Abstract Doc Link 9549524 Disease Relevance 0.95 Pain Relevance 0.78
Prominent infiltration of inflammatory cells into the sciatic nerve was concordant with a significant increase in the expression levels of matrilysin and macrophage metalloelastase.
Gene_expression (expression) of macrophage metalloelastase in sciatic nerve associated with inflammation and sciatic nerve
2) Confidence 0.31 Published 1998 Journal Brain Section Abstract Doc Link 9549524 Disease Relevance 1.03 Pain Relevance 0.84
Further studies are required to determine the precise role of PDE4 in modulating MMP12 synthesis and release from alveolar macrophages.
Gene_expression (synthesis) of MMP12 in alveolar macrophages
3) Confidence 0.22 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.56 Pain Relevance 0.12
By increasing the expression of matrix metalloproteinases (MMP-3, MMP-9, MMP-10, MMP-12, and MMP-13) while inhibiting the expression of genes encoding essential components of the ECM (such as collagen type II and aggrecan-1), the elevated IL-1?
Gene_expression (expression) of MMP-12 associated with metalloproteinase
4) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.20 Pain Relevance 0.30
It also blocked the IL-1-induced expression of matrix-specific proteases such as MMP-3, MMP-9, MMP-10, MMP-12, and ADAMTS-1.
Gene_expression (expression) of MMP-12
5) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794517 Disease Relevance 0.26 Pain Relevance 0.18
Both matrilysin and macrophage metalloelastase were detected in invading macrophages, T lymphocytes and resident Schwann cells.
Gene_expression (detected) of macrophage metalloelastase in T lymphocytes
6) Confidence 0.10 Published 1998 Journal Brain Section Abstract Doc Link 9549524 Disease Relevance 0.95 Pain Relevance 0.78
Bronchoalveolar lavage samples from human subjects with COPD associated with wood-smoke exposure demonstrated significantly higher MMP activity, specifically pro-MMP-2, pro-MMP-9, and MMP-9, and gene expression of MMP-2 and MMP-12, when compared with healthy controls (Montano et al. 2004).
Gene_expression (expression) of MMP-12 associated with pulmonary disease and metalloproteinase
7) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459932 Disease Relevance 0.96 Pain Relevance 0.42
Increased levels of MMP-2, MMP-3, MMP-9 and MMP-12 have been identified in aneurysm vessel walls [23-27].
Gene_expression (levels) of MMP-12 associated with aneurism
8) Confidence 0.06 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.79 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox