INT74688

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 8
Speculated 11
Reported most in Abstract
Documents 55
Total Number 67
Disease Relevance 22.16
Pain Relevance 25.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 11
sympathetic 4
nucleus 3
spinal 3
spinal cord 3
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 79 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
anesthesia 23 99.92 Very High Very High Very High
electroacupuncture 133 99.82 Very High Very High Very High
Spinal sensitization 3 99.80 Very High Very High Very High
Stimulus evoked pain 2 99.72 Very High Very High Very High
medulla 83 99.68 Very High Very High Very High
Sciatic nerve 19 99.68 Very High Very High Very High
Clonidine 24 99.64 Very High Very High Very High
Hyperalgesia 17 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 67 100.00 Very High Very High Very High
Nociception 39 100.00 Very High Very High Very High
Schizophrenia 42 99.84 Very High Very High Very High
Hypersensitivity 4 99.72 Very High Very High Very High
Hyperalgesia 18 99.64 Very High Very High Very High
Pain 37 99.54 Very High Very High Very High
Diabetic Neuropathy 4 99.46 Very High Very High Very High
Salivary Gland Disease 11 99.44 Very High Very High Very High
Cough 144 99.12 Very High Very High Very High
Diabetes Mellitus 138 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite in vivo studies suggesting an important function for nitric oxide (NO) in the spinal cord in the transmission of pain signals, sympathetic nerve activity and presumably other spinal functions, changes of neuronal NO synthase (nNOS)-containing neurons with aging in the spinal cord has not been investigated.
Regulation (changes) of nNOS in sympathetic associated with pain, aging and spinal cord
1) Confidence 0.62 Published 2005 Journal J. Mol. Histol. Section Abstract Doc Link 16240168 Disease Relevance 0.25 Pain Relevance 0.38
Thus, regulation of nNOS may contribute to the development of neuronal plasticity after specific types of peripheral nerve injury.
Regulation (regulation) of nNOS in neuronal associated with nervous system injury and peripheral nerve injury
2) Confidence 0.62 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.96 Pain Relevance 0.94
The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.
Regulation (influence) of nitric oxide synthase 1 in kidney associated with anesthesia
3) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 11404282 Disease Relevance 0 Pain Relevance 0.16
The aim of this study was to investigate the electroacupuncture-related changes of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the brainstem of spontaneously hypertensive rats (SHR).
Regulation (changes) of nNOS in brainstem associated with medulla, hypertension, electroacupuncture and neuronal nitric oxide synthase
4) Confidence 0.60 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11595335 Disease Relevance 0.17 Pain Relevance 0.32
The present study was aimed at the determination of the gene expression of nNOS-interacting DHHC domain-containing protein with dendritic mRNA (NIDD), a recently identified protein regulating nNOS enzyme activity, in rat SC and dorsal root ganglia (DRG) and studying its regulation in states of nociceptive hypersensitivity in a rat model of neuropathic or inflammatory pain.
Regulation (regulating) of nNOS in DRG associated with nociception, ipn, neuropathic pain, hypersensitivity and spinal cord
5) Confidence 0.58 Published 2008 Journal J. Mol. Histol. Section Abstract Doc Link 17899403 Disease Relevance 0.91 Pain Relevance 0.68
Importantly, we clarified the potential roles of PKCgamma in the regulation of nNOS and COX-2 following intrathecal injection with KA in the rat spinal cord.
Regulation (regulation) of nNOS in spinal cord associated with spinal cord and intrathecal
6) Confidence 0.56 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489538 Disease Relevance 0 Pain Relevance 0.52
However, rosuvastatin had no influence on nNOS mRNA and protein expression.
Neg (no) Regulation (influence) of nNOS
7) Confidence 0.55 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513366 Disease Relevance 0.67 Pain Relevance 0.45
The present data support a role for abnormal nNOS activity in mechanisms that trigger seizures and suggest a possible NO-mediated interplay between GABA(A) and glutamate receptors.
Regulation (role) of nNOS associated with gaba, convulsion and glutamate receptor
8) Confidence 0.54 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850575 Disease Relevance 0.25 Pain Relevance 0.51
These findings imply that NIDD may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival, and even pain process, possibly via regulating the enzyme nNOS activity.
Regulation (regulating) of nNOS in nerve associated with pain
9) Confidence 0.53 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17873365 Disease Relevance 0.10 Pain Relevance 0.19
The aim of this study was to investigate the electroacupuncture-related changes of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the brainstem of spontaneously hypertensive rats (SHR).
Regulation (changes) of neuronal nitric oxide synthase in brainstem associated with medulla, hypertension, electroacupuncture and neuronal nitric oxide synthase
10) Confidence 0.53 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11595335 Disease Relevance 0.17 Pain Relevance 0.32
Electroacupuncture-related changes of NADPH-diaphorase and neuronal nitric oxide synthase in the brainstem of spontaneously hypertensive rats.
Regulation (changes) of neuronal nitric oxide synthase in brainstem associated with medulla, hypertension, electroacupuncture and neuronal nitric oxide synthase
11) Confidence 0.53 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11595335 Disease Relevance 0.19 Pain Relevance 0.64
Our data suggest a potential role for NIDD in the maintenance of thermal pain hypersensitivity possibly via regulating the nNOS activity.
Regulation (regulating) of nNOS associated with hypersensitivity and stimulus evoked pain
12) Confidence 0.50 Published 2008 Journal J. Mol. Histol. Section Abstract Doc Link 17899403 Disease Relevance 1.07 Pain Relevance 0.73
Carboxy-terminal post synaptic density protein/Drosophila disc large tumor suppressor/zonula occuldens-1 protein (PDZ) ligand of neuronal nitric oxide synthase (CAPON), as an adaptor, interacts with nNOS via the PDZ domain helping regulate nNOS activity at postsynaptic sites in neurons.
Regulation (regulate) of nNOS in neurons associated with cancer and neuronal nitric oxide synthase
13) Confidence 0.48 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 17768032 Disease Relevance 0.10 Pain Relevance 0.20
These results suggest that CAPON as well as Dexras1 may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival and even pain process, possibly via regulating the nNOS activity or through the downstream targets of Dexras1.
Regulation (regulating) of nNOS in nerve associated with pain
14) Confidence 0.48 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 17768032 Disease Relevance 0.10 Pain Relevance 0.24
The purpose of our study was to investigate the possible influence of local injections of botulinum toxin A on the activity of neuronal nitric oxide synthase (nNOS) in cephalic salivary glands of adult rats.
Spec (possible) Regulation (influence) of nNOS in salivary glands associated with salivary gland disease and neuronal nitric oxide synthase
15) Confidence 0.45 Published 2003 Journal ORL J. Otorhinolaryngol. Relat. Spec. Section Abstract Doc Link 12925814 Disease Relevance 0.25 Pain Relevance 0.12
Despite in vivo studies suggesting an important function for nitric oxide (NO) in the spinal cord in the transmission of pain signals, sympathetic nerve activity and presumably other spinal functions, changes of neuronal NO synthase (nNOS)-containing neurons with aging in the spinal cord has not been investigated.
Regulation (changes) of neuronal NO synthase in sympathetic associated with pain, aging and spinal cord
16) Confidence 0.45 Published 2005 Journal J. Mol. Histol. Section Abstract Doc Link 16240168 Disease Relevance 0.25 Pain Relevance 0.38
In previous studies, neuronal nitric oxide synthase (nNOS) in the jejunal myenteric plexus, a key enzyme responsible for the release of NO, has been demonstrated to increase after splanchinic ganglionectomy (sympathetic nerve transection).
Regulation (responsible) of nNOS in sympathetic associated with ganglionectomy and neuronal nitric oxide synthase
17) Confidence 0.45 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.42
To assess the possible roles of neuronal nitric oxide synthase (nNOS) in spinal sensitization after nerve injury, we examined the distribution of nNOS immunoreactivity in dorsal root ganglia (DRGs) and dorsal horn of the corresponding spinal segments.
Spec (possible) Regulation (roles) of nNOS in spinal associated with nervous system injury, spinal sensitization, dorsal horn and neuronal nitric oxide synthase
18) Confidence 0.45 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12127013 Disease Relevance 0.34 Pain Relevance 0.44
To elucidate how glucocorticoids affect this mechanism, we studied the effects of intrathecal (it) injection of prednisolone acetate (PA) on a nociceptive stimulus and the changes of nNOS and NR2B subunit expression in the spinal dorsal horn of Sprague Dawley rats following chronic compression of the dorsal root ganglia (CCD).
Regulation (changes) of nNOS in spinal associated with nociception, spinal dorsal horn and intrathecal
19) Confidence 0.45 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.33 Pain Relevance 0.67
The effects of the putatively selective inhibitor of neuronal nitric oxide synthase (nNOS) 1-(2-trifluoromethylphenyl) imidazole (TRIM) were investigated on contractility, intracellular calcium and nitrergic relaxations in the rat anococcygeus muscle.
Regulation (effects) of neuronal nitric oxide synthase in anococcygeus associated with neuronal nitric oxide synthase
20) Confidence 0.45 Published 2007 Journal Nitric Oxide Section Abstract Doc Link 16769230 Disease Relevance 0 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox