INT7469

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 4.70
Pain Relevance 14.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
PVN 7
plasma 6
neurons 4
SON 3
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 31 100.00 Very High Very High Very High
Morphine 26 100.00 Very High Very High Very High
Enkephalin 12 99.98 Very High Very High Very High
fluoxetine 34 99.96 Very High Very High Very High
Serotonin 18 99.96 Very High Very High Very High
Neuropeptide 4 99.84 Very High Very High Very High
Pain 44 99.74 Very High Very High Very High
intrathecal 7 99.62 Very High Very High Very High
Pain threshold 4 99.62 Very High Very High Very High
withdrawal 2 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 62 99.74 Very High Very High Very High
Anxiety Disorder 20 99.38 Very High Very High Very High
Pressure And Volume Under Development 1 99.14 Very High Very High Very High
Stress 15 99.04 Very High Very High Very High
Urological Neuroanatomy 5 98.84 Very High Very High Very High
Hemorrhage 6 98.28 Very High Very High Very High
INFLAMMATION 8 96.32 Very High Very High Very High
Nociception 2 93.56 High High
Aggression 3 83.44 Quite High
Body Weight 1 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent evidence that 5-hydroxytryptamine (5-HT or serotonin) enhances the release and the gene expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) suggests that 5-HT can excite the PVN magnocellular neurons.
Positive_regulation (enhances) of Gene_expression (expression) of oxytocin in nucleus associated with serotonin
1) Confidence 0.59 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561813 Disease Relevance 0 Pain Relevance 0.21
However, intravenous injection of oxytocin or anti-oxytocin serum did not influence acupuncture analgesia.
Positive_regulation (injection) of Gene_expression (injection) of anti-oxytocin associated with acupuncture and analgesia
2) Confidence 0.50 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17664006 Disease Relevance 0.24 Pain Relevance 1.23
However, intravenous injection of oxytocin or anti-oxytocin serum did not influence acupuncture analgesia.
Positive_regulation (injection) of Gene_expression (injection) of oxytocin associated with acupuncture and analgesia
3) Confidence 0.50 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17664006 Disease Relevance 0.24 Pain Relevance 1.22
There was a negative relationship between the PVN AVP concentration and the pain threshold; pain stimulation enhanced the AVP, not OXT mRNA expression in the PVN using in situ hybridization and RT-PCR; intraventricular injection of anti-AVP serum completely reversed L-glutamate sodium injection into the PVN-induced antinociception, and administration of naloxone - the opiate peptide antagonist, partly blocked this L-glutamate sodium effect, but anti-OXT serum pretreatment did not influence this L-glutamate sodium effect; L-glutamate sodium injection into the PVN-induced analgesia was inhibited by V2 receptor antagonist - d(CH2)5[D-Ile2, Ile4, Ala-NH2(9)]AVP, not V1 receptor antagonist - d(CH2)5Tyr(Me)AVP.
Positive_regulation (enhanced) of Gene_expression (expression) of OXT mRNA in PVN associated with antinociception, pain, glutamate, pain threshold, antagonist, narcan, opiate and analgesia
4) Confidence 0.48 Published 2006 Journal Brain Res. Section Abstract Doc Link 16409991 Disease Relevance 0.49 Pain Relevance 1.76
Intrathecal administration of oxytocin produced dose-dependent increases in the hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with inflammation.
Positive_regulation (increases) of Gene_expression (produced) of oxytocin associated with inflammation, withdrawal and intrathecal
5) Confidence 0.47 Published 2003 Journal Brain Res. Section Abstract Doc Link 12914962 Disease Relevance 0.32 Pain Relevance 0.95
The oxytocin innervation of these neurones and their expression of oxytocin receptors increases in the postpartum period, and the resultant enhanced sensitivity leads to a greater facilitatory response during lactation.
Positive_regulation (increases) of Gene_expression (expression) of oxytocin
6) Confidence 0.47 Published 1995 Journal J. Neuroendocrinol. Section Abstract Doc Link 7735292 Disease Relevance 0.08 Pain Relevance 0.13
In morphine-L dependent rats, naloxone increased the levels of oxytocin in SON and PVN, but decreased that in LC.
Positive_regulation (increased) of Gene_expression (levels) of oxytocin in SON associated with locus ceruleus, narcan and morphine
7) Confidence 0.45 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043533 Disease Relevance 0.10 Pain Relevance 0.88
Increases in plasma AVP and OT levels in response to both hypertonic saline and hemorrhage were markedly blunted in the hyponatremic rats compared to the normonatremic rats.
Positive_regulation (Increases) of Gene_expression (levels) of OT in plasma associated with cva
8) Confidence 0.41 Published 1995 Journal J. Neuroendocrinol. Section Abstract Doc Link 7735298 Disease Relevance 0.24 Pain Relevance 0.39
In water-sated rats, both L-arginine and kyotorphin increased blood pressure and plasma glucose levels coincident with elevating circulating levels of oxytocin, but not vasopressin.
Positive_regulation (elevating) of Gene_expression (levels) of oxytocin in plasma associated with pressure and volume under development
9) Confidence 0.37 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9527014 Disease Relevance 0.10 Pain Relevance 0.07
Naloxone also increased (p less than 0.05) oxytocin concentration in controls receiving CSF or saline.
Positive_regulation (increased) of Gene_expression (concentration) of oxytocin associated with narcan
10) Confidence 0.35 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796791 Disease Relevance 0 Pain Relevance 0.41
Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brain.
Positive_regulation (induces) of Gene_expression (expression) of oxytocin in neurons associated with catecholamine and neuropeptide
11) Confidence 0.31 Published 2009 Journal Brain Res. Section Title Doc Link 18955037 Disease Relevance 0.21 Pain Relevance 0.50
Injecting 8-OH-DPAT to saline pretreated rats produced a significant increase in plasma oxytocin (299%), ACTH (1456%) and corticosterone (170%) levels but not in plasma prolactin or renin concentrations.
Positive_regulation (increase) of Gene_expression (levels) of oxytocin in plasma
12) Confidence 0.29 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12213258 Disease Relevance 0.08 Pain Relevance 0.84
Under stress conditions, (1) cortisol concentrations were elevated throughout the 60-min sampling period after naloxone or saline but for only 20 min after morphine; maximum increases observed were 161% (naloxone), 150% (saline) and 112% (morphine); (2) prolactin levels were raised after saline (85-129%) and morphine (55-61%) but were unchanged after naloxone; (3) vasopressin concentrations decreased transiently (43%) after saline but not following naloxone or morphine; and (4) oxytocin levels did not change after any treatment.
Positive_regulation (increases) of Gene_expression (levels) of oxytocin associated with stress, narcan and morphine
13) Confidence 0.28 Published 1989 Journal Psychoneuroendocrinology Section Abstract Doc Link 2560223 Disease Relevance 0.33 Pain Relevance 1.07
Under stress conditions, (1) cortisol concentrations were elevated throughout the 60-min sampling period after naloxone or saline but for only 20 min after morphine; maximum increases observed were 161% (naloxone), 150% (saline) and 112% (morphine); (2) prolactin levels were raised after saline (85-129%) and morphine (55-61%) but were unchanged after naloxone; (3) vasopressin concentrations decreased transiently (43%) after saline but not following naloxone or morphine; and (4) oxytocin levels did not change after any treatment.
Neg (not) Positive_regulation (change) of Gene_expression (levels) of oxytocin associated with stress, narcan and morphine
14) Confidence 0.28 Published 1989 Journal Psychoneuroendocrinology Section Abstract Doc Link 2560223 Disease Relevance 0.31 Pain Relevance 1.02
The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
Positive_regulation (increased) of Gene_expression (expression) of oxytocin in PVN associated with fluoxetine
15) Confidence 0.28 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0.09 Pain Relevance 0.44
Our results suggest that enkephalin expression in both vasopressin and oxytocin neurons may increase in response to chronic stresses and provide another source of enkephalin in addition to the parvocellular neurons.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of oxytocin in neurons associated with stress and enkephalin
16) Confidence 0.21 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1349719 Disease Relevance 0.26 Pain Relevance 0.63
These changes resulting from maternal experience may facilitate the expression of oxytocin-mediated functions, such as milk ejection, in connection with later pregnancies.
Spec (may) Positive_regulation (facilitate) of Gene_expression (expression) of oxytocin
17) Confidence 0.17 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1878468 Disease Relevance 0 Pain Relevance 0
In morphine-L dependent rats, naloxone increased the levels of oxytocin in SON and PVN, but decreased that in LC.
Positive_regulation (increased) of in PVN Gene_expression (levels) of oxytocin in SON associated with locus ceruleus, narcan and morphine
18) Confidence 0.15 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043533 Disease Relevance 0.10 Pain Relevance 0.88
This effect is in part related to the increased level of oxytocin in the periaquaductal gray (PAG), which can influence the descending antinociceptive system.15
Positive_regulation (increased) of Gene_expression (level) of oxytocin associated with urological neuroanatomy and antinociceptive
19) Confidence 0.07 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813537 Disease Relevance 0.91 Pain Relevance 1.01
The occurrence of OCD has also been correlated with increased levels of oxytocin, a neuropeptide closely related to AVP [37].
Positive_regulation (increased) of Gene_expression (levels) of oxytocin associated with anxiety disorder and neuropeptide
20) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC55332 Disease Relevance 0.61 Pain Relevance 0.74

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