INT74695

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Context Info
Confidence 0.73
First Reported 1998
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 41
Total Number 43
Disease Relevance 53.33
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
liver 9
macrophages 2
placenta 2
kidney 2
blood 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
metalloproteinase 63 99.10 Very High Very High Very High
Peripheral nervous system 4 99.06 Very High Very High Very High
Endogenous opioid 3 98.20 Very High Very High Very High
cytokine 29 97.60 Very High Very High Very High
Inflammation 103 97.24 Very High Very High Very High
Multiple sclerosis 3 94.88 High High
Neuritis 1 89.92 High High
alcohol 2 88.20 High High
Disease Link Frequency Relevance Heat
Colon Cancer 1968 100.00 Very High Very High Very High
Metastasis 1920 99.98 Very High Very High Very High
Cancer 1809 99.84 Very High Very High Very High
Duchenne Muscular Dystrophy 40 98.28 Very High Very High Very High
Muscular Dystrophy 280 98.12 Very High Very High Very High
Hypertrophic Cardiomyopathy 84 97.72 Very High Very High Very High
Stress 27 97.48 Very High Very High Very High
INFLAMMATION 103 97.24 Very High Very High Very High
Alcohol Addiction 2 97.20 Very High Very High Very High
Frailty 151 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE-2 is expressed in the kidney, heart and other organs and is not inhibited by ACE inhibitors [17].
Gene_expression (expressed) of ACE in heart
1) Confidence 0.73 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.33 Pain Relevance 0
Our past clinical research also proved that ACEI preparation Fosinopril can inhibit NF-?
Gene_expression (preparation) of ACE
2) Confidence 0.65 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.65 Pain Relevance 0.23
and MMPs/TIMPs.7 The results of this study show that ACEI preparation Benazepril can remarkably reduce TLR4, TNF-?
Gene_expression (preparation) of ACE associated with metalloproteinase
3) Confidence 0.65 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.66 Pain Relevance 0.23
Our current results suggest a possible explanation for this, as the increased expression of ACE mRNA (and protein) at this time would require additional, or at least continued, captopril treatment to ensure sustained inhibition of ACE activity.


Gene_expression (expression) of ACE mRNA
4) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.66 Pain Relevance 0
The timing of this reduction in ACE expression is of interest as it occurs during the critical exponential growth phase (day 10 to 19).
Gene_expression (expression) of ACE
5) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.99 Pain Relevance 0
However, our immunohistochemical analysis suggests that at least some of the expression of ACE in CRC metastases is derived from infiltrating cells.
Gene_expression (expression) of ACE associated with colon cancer and metastasis
6) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.64 Pain Relevance 0
The significant reduction in ACE expression at day 16 following captopril treatment suggests that in addition to the inhibition of ACE activity, captopril also reduces ACE levels, presumably leading to an even greater inhibition of ANG II production.
Gene_expression (expression) of ACE
7) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.32 Pain Relevance 0
In particular, CRC metastases were characterised by high ACE and MasR expression, but low AT1R and angiotensinogen mRNA levels compared to the liver.
Gene_expression (expression) of ACE in liver associated with colon cancer and metastasis
8) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.03 Pain Relevance 0
A significant increase in ACE mRNA expression was observed at day 5 in the tumor-bearing liver compared to sham livers (P = 0.0412), indicating an effect of tumor induction.
Gene_expression (expression) of ACE mRNA in liver associated with cancer
9) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.21 Pain Relevance 0
However, in the late plateau stages (day 21 onwards) of CRC metastases growth, captopril treatment was associated with a reversion of ACE expression back to the levels seen in untreated tumors at day 21.
Gene_expression (expression) of ACE associated with cancer, colon cancer and metastasis
10) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.86 Pain Relevance 0
ACE and ACE2 expression in CRC liver metastases
Gene_expression (expression) of ACE in liver associated with colon cancer and metastasis
11) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.41 Pain Relevance 0
Key components of the RAS, namely angiotensinogen, ACE, ACE2, AT1R, AT2R, and the MasR were expressed in the sham liver, tumor-induced liver, and in CRC liver metastases (tumors) at all stages examined.
Gene_expression (expressed) of ACE in liver associated with cancer, colon cancer and metastasis
12) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.00 Pain Relevance 0
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Gene_expression (expression) of ACE in liver associated with cancer, colon cancer and metastasis
13) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.69 Pain Relevance 0
The genotyping of the 5-HT2A, 5-HTT, AGT, ACE, and AT1R polymorphisms showed a significantly higher frequency of carriers of the AT1R C allele (AC+CC genotypes) in the HCM patients without sarcomeric gene mutations compared to the healthy controls (p = 0.015; OR = 1.56; 95% CI = 1.09-2.23) (Table 2).
Gene_expression (genotyping) of ACE associated with hypertrophic cardiomyopathy
14) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.81 Pain Relevance 0
We examined the difference for the main characteristics between the 5-HT2A, 5-HTT, AGT, ACE, and AT1R genotypes in the 205 patients without sarcomeric mutations.
Gene_expression (genotypes) of ACE
15) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.57 Pain Relevance 0
It is known that infiltrating macrophages, which typically associate with stromal intrusions, express ACE [40].
Gene_expression (express) of ACE in macrophages
16) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.38 Pain Relevance 0
ACE, AT1R, MasR, and angiotensinogen were differentially expressed in control CRC liver metastases compared to the naïve (non-tumor bearing) and the tumor-bearing liver.
Gene_expression (expressed) of ACE in liver associated with cancer, colon cancer and metastasis
17) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.20 Pain Relevance 0
JZ established ACE IHC protocols.
Gene_expression (protocols) of ACE IHC
18) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.92 Pain Relevance 0
ACE and ACE2 expression in CRC liver metastases
Gene_expression (liver) of ACE in liver associated with colon cancer and metastasis
19) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.42 Pain Relevance 0
In the first experiment, basal mRNA levels of mu- and delta-opioid receptors, and of opioid-degrading enzymes enkephalinase (neutral endopeptidase 24.11; NEP) and angiotensin-converting enzyme (ACE) in the brain regions of C57BL/6 and DBA/2 mice did not reveal genetically determined differences in these parameters between the two strains.
Spec (determined) Gene_expression (levels) of ACE in brain associated with delta opioid receptors, sprains and strains and opioid
20) Confidence 0.56 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.35 Pain Relevance 0.37

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