INT7470

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2010
Negated 0
Speculated 6
Reported most in Abstract
Documents 37
Total Number 44
Disease Relevance 19.55
Pain Relevance 19.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
neurons 19
PVN 12
plasma 6
pituitary 4
autonomic 3
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 53 100.00 Very High Very High Very High
Enkephalin 42 100.00 Very High Very High Very High
opioid receptor 9 99.98 Very High Very High Very High
Serotonin 20 99.96 Very High Very High Very High
Raphe magnus 25 99.68 Very High Very High Very High
Pain threshold 11 99.62 Very High Very High Very High
Morphine 9 99.60 Very High Very High Very High
cocaine 30 99.44 Very High Very High Very High
tetrodotoxin 12 99.40 Very High Very High Very High
Central grey 24 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 5 99.92 Very High Very High Very High
Chronic Renal Failure 124 99.82 Very High Very High Very High
Stress 64 99.80 Very High Very High Very High
Pain 55 99.74 Very High Very High Very High
Myocardial Infarction 90 99.68 Very High Very High Very High
Shock 44 99.44 Very High Very High Very High
Urological Neuroanatomy 31 99.32 Very High Very High Very High
Aggression 93 99.00 Very High Very High Very High
Hyponatremia 85 98.96 Very High Very High Very High
Diabetes Mellitus 6 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN.
Positive_regulation (induced) of Gene_expression (expression) of AVP hnRNA in PVN associated with tetrodotoxin and sodium channel
1) Confidence 0.70 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.15
Furthermore, AVP hnRNA expression induced by forskolin was attenuated by dexamethasone treatment in the presence of TTX.
Positive_regulation (induced) of Gene_expression (expression) of AVP hnRNA associated with tetrodotoxin and dexamethasone
2) Confidence 0.70 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.66
The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.
Spec (might) Positive_regulation (transferred) of Gene_expression (transferred) of AVP in PVN associated with pain and raphe magnus
3) Confidence 0.70 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.65 Pain Relevance 1.04
Hence, a functional MAPK signaling pathway appears to be critical for AVP gene expression in the SCN.
Spec (appears) Positive_regulation (critical) of Gene_expression (expression) of AVP gene in SCN
4) Confidence 0.69 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.47
Parvocellular neurones showed expected increases in vasopressin hnRNA expression following LPS injection and a further increase after i.p. hypertonic saline injection (due to the painful component).
Positive_regulation (increases) of Gene_expression (expression) of vasopressin hnRNA associated with pain
5) Confidence 0.69 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12535156 Disease Relevance 0.09 Pain Relevance 0.10
Electrical acupuncture of "Zusanli" points (St. 36) decreased AVP concentration in the hypothalamic paraventricular nucleus (PVN), and increased AVP concentration in the hypothalamic supraoptic nucleus (SON), periaqueductial gray (PAG), caudate nucleus (CdN) and raphe magnus nucleus (RMN), but did not change AVP concentration in the pituitary, spinal cord and plasma.
Positive_regulation (increased) of Gene_expression (concentration) of AVP in raphe magnus nucleus associated with raphe magnus, urological neuroanatomy, acupuncture and spinal cord
6) Confidence 0.50 Published 2009 Journal Peptides Section Abstract Doc Link 19022309 Disease Relevance 0.17 Pain Relevance 1.34
The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid.
Positive_regulation (increase) of Gene_expression (concentration) of AVP in neurons associated with raphe magnus, pain and glutamate
7) Confidence 0.50 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.58 Pain Relevance 1.07
The colchicine procedure reported increases in AVP synthesis in both the SON and PVH in diabetic animals, a result compatible with that obtained previously for whole hypothalamus using radiolabeled procedures.
Positive_regulation (increases) of Gene_expression (synthesis) of AVP in hypothalamus associated with diabetes mellitus
8) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0.20 Pain Relevance 0.44
Basal vasopressin mRNA expression in the paraventricular and supraoptic nuclei decreased slightly 6 h after LPS injection, without changes in vasopressin transcription as indicated by vasopressin heteronuclear (hn) RNA levels.
Positive_regulation (Basal) of Gene_expression (expression) of vasopressin mRNA
9) Confidence 0.50 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12535156 Disease Relevance 0.10 Pain Relevance 0.07
Role of the ICF compartment in reducing variability of ECF [Na+] and circulating AVP level
Positive_regulation (circulating) of Gene_expression (level) of AVP
10) Confidence 0.50 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0 Pain Relevance 0
The results showed that: (1) pain stimulation elevated AVP concentration in both PVN and PAG perfusion liquid, in which the peak of AVP concentration in PVN perfusion liquid occurred earlier than that in PAG perfusion liquid; (2) PVN cauterization weakened pain stimulation-induced PAG releasing AVP, in which the inhibitive effect of bilateral PVN cauterization showed stronger than that of unilateral PVN cauterization; (3) microinjection of l-glutamate sodium into PVN, which excited local neurons, increased AVP concentration in PAG perfusion liquid in a dose-dependent manner.
Positive_regulation (elevated) of Gene_expression (concentration) of AVP in neurons associated with pain, glutamate and central grey
11) Confidence 0.49 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123712 Disease Relevance 1.28 Pain Relevance 1.17
At the 5 d after surgery AVP stored in the magnocellular neurons in the hypothalamus nuclei was released by the ectopic neural lobe and the plasma AVP concentration increased.
Positive_regulation (increased) of Gene_expression (concentration) of plasma AVP in neural lobe
12) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.60 Pain Relevance 0.03
The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid.
Positive_regulation (elevated) of Gene_expression (concentrations) of AVP associated with dopamine, glutamate, gaba, neurotransmitter, enkephalin, central grey and serotonin
13) Confidence 0.49 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17341433 Disease Relevance 0.75 Pain Relevance 1.50
ANT lesions also produced an up-regulation of CRH and AVP mRNA relative to operated control rats.
Positive_regulation (up-regulation) of Gene_expression (produced) of AVP in ANT
14) Confidence 0.49 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0
Finally, tetraethylammonium and apamine also antagonized the inhibition of CRF/AVP-evoked ACTH release by 8-Br-cGMP.
Positive_regulation (evoked) of Gene_expression (evoked) of AVP
15) Confidence 0.49 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2169519 Disease Relevance 0 Pain Relevance 0.06
Twenty-four hr later, immunoreactive (IR) levels of AVP and OXT increased considerably, as previously noted.
Positive_regulation (increased) of Gene_expression (levels) of AVP
16) Confidence 0.46 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0.12 Pain Relevance 0.35
There was marked upregulation of cleaved Caspase-3 expression of vasopressin neurons in hypophysectomy rats.
Positive_regulation (upregulation) of Gene_expression (expression) of vasopressin in neurons
17) Confidence 0.46 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2442085 Disease Relevance 0.88 Pain Relevance 0
There was a negative relationship between the PVN AVP concentration and the pain threshold; pain stimulation enhanced the AVP, not OXT mRNA expression in the PVN using in situ hybridization and RT-PCR; intraventricular injection of anti-AVP serum completely reversed L-glutamate sodium injection into the PVN-induced antinociception, and administration of naloxone - the opiate peptide antagonist, partly blocked this L-glutamate sodium effect, but anti-OXT serum pretreatment did not influence this L-glutamate sodium effect; L-glutamate sodium injection into the PVN-induced analgesia was inhibited by V2 receptor antagonist - d(CH2)5[D-Ile2, Ile4, Ala-NH2(9)]AVP, not V1 receptor antagonist - d(CH2)5Tyr(Me)AVP.
Positive_regulation (enhanced) of Gene_expression (expression) of AVP in PVN associated with antinociception, pain, glutamate, pain threshold, antagonist, narcan, opiate and analgesia
18) Confidence 0.46 Published 2006 Journal Brain Res. Section Abstract Doc Link 16409991 Disease Relevance 0.49 Pain Relevance 1.76
Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation.
Positive_regulation (transferred) of Gene_expression (transferred) of Arginine vasopressin in nucleus associated with pain and raphe magnus
19) Confidence 0.45 Published 2009 Journal Peptides Section Title Doc Link 19520128 Disease Relevance 0.59 Pain Relevance 1.08
The results showed that (1) pain stimulation increased both NA and AVP concentrations in the PVN perfusion liquid; (2) PVN administration of l-glutamate sodium increased AVP, not NA concentration in the PVN perfusion liquid; (3) AVP or d(CH(2))(5)Tyr(Et)DAVP (AVP-receptor antagonist) neither changed pain threshold, nor influenced NA concentration in the PVN perfusion liquid; (4) Microinjection of NA into PVN could increase pain threshold in a dose-dependent manner, while PVN administration with phentolamine (alpha-receptor antagonist), not propranolol (beta-receptor antagonist) decreased pain threshold; (5) Administration of NA increased AVP concentration, while phentolamine, not propranolol decreased AVP concentration in the PVN perfusion liquid.
Positive_regulation (increased) of Gene_expression (concentrations) of AVP in PVN associated with pain, pain threshold, glutamate and antagonist
20) Confidence 0.44 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19573913 Disease Relevance 0.69 Pain Relevance 0.91

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