INT74716

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.17
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Htr4) plasma membrane (Htr4) cytoplasm (Htr4)
signal transducer activity (Htr4)
Anatomy Link Frequency
visceral 2
Htr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nud 1 98.64 Very High Very High Very High
analgesia 9 98.48 Very High Very High Very High
antinociception 3 98.36 Very High Very High Very High
hypoalgesia 9 97.96 Very High Very High Very High
Pain 12 93.48 High High
antagonist 14 87.36 High High
Visceral pain 3 71.60 Quite High
agonist 10 50.00 Quite Low
Serotonin 4 10.00 Low Low
Cholecystokinin 1 8.56 Low Low
Disease Link Frequency Relevance Heat
Dyspepsia 1 98.64 Very High Very High Very High
Hypoalagesia 9 97.96 Very High Very High Very High
Nociception 6 96.68 Very High Very High Very High
Pain 9 93.48 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 71.60 Quite High
Gallstones 6 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 3 5.00 Very Low Very Low Very Low
Gallbladder Disease 3 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rationale for the therapeutic use of agents acting at 5-HT4 receptors to modulate visceral hypersensitivity supposes that continuous mucosal stimuli cause auto-inhibition and desensitization of 5-HT4 receptors [49], and intramural sensory pathways [50].
Negative_regulation (desensitization) of 5-HT4 in visceral associated with nud
1) Confidence 0.42 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1434748 Disease Relevance 0.10 Pain Relevance 0.05
In summary, findings of the present study imply that: i) antagonism of 5-HT4 receptors mediates antinociception in enteric viscera and, to a lesser extent, in cutaneous terminals, and ii) dual inactivation of both 5-HT4 and 5-HT3 receptors induces visceral analgesia, a fact which might have clinical importance.
Negative_regulation (inactivation) of 5-HT4 in visceral associated with antinociception and analgesia
2) Confidence 0.42 Published 1998 Journal Brain Res. Section Abstract Doc Link 9554939 Disease Relevance 0.59 Pain Relevance 0.88
This effect was likely mediated through inactivation of peripheral 5-HT4 receptors.
Negative_regulation (inactivation) of 5-HT4
3) Confidence 0.42 Published 1998 Journal Brain Res. Section Abstract Doc Link 9554939 Disease Relevance 0.67 Pain Relevance 0.85
After the 1:1 combination, the hypoalgesic effect disappeared, which indicates that simultaneous inactivation of 5-HT3 and 5-HT4 receptors antagonized peripherally 5-HT4-mediated hypoalgesia by an unknown mechanism.
Negative_regulation (inactivation) of 5-HT4 associated with hypoalgesia
4) Confidence 0.18 Published 1998 Journal Brain Res. Section Abstract Doc Link 9554939 Disease Relevance 0.68 Pain Relevance 0.94

General Comments

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