INT74726

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2011
Negated 0
Speculated 5
Reported most in Abstract
Documents 61
Total Number 66
Disease Relevance 21.01
Pain Relevance 27.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
cortex 4
brain 3
adult brain 2
synapse 2
precursor cell 2
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 766 100.00 Very High Very High Very High
Dopamine 308 100.00 Very High Very High Very High
sSRI 730 99.98 Very High Very High Very High
fluoxetine 607 99.98 Very High Very High Very High
cocaine 483 99.98 Very High Very High Very High
Nucleus accumbens 22 99.84 Very High Very High Very High
Desipramine 4 99.80 Very High Very High Very High
Kinase C 45 99.66 Very High Very High Very High
Hippocampus 53 99.58 Very High Very High Very High
isoflurane 23 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 281 99.92 Very High Very High Very High
Hyperplasia 4 99.90 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

28 99.88 Very High Very High Very High
Cognitive Disorder 10 99.86 Very High Very High Very High
Depression 224 99.64 Very High Very High Very High
Anxiety Disorder 150 99.40 Very High Very High Very High
INFLAMMATION 23 99.32 Very High Very High Very High
Hypoxia 8 98.96 Very High Very High Very High
Acidosis 171 98.90 Very High Very High Very High
Disease 15 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of this investigation was to determine whether inhibition of SERT function leads to changes in gut motility and sensitivity.
Spec (whether) Negative_regulation (inhibition) of SERT in gut
1) Confidence 0.59 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16700726 Disease Relevance 0.42 Pain Relevance 0.40
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction.
Negative_regulation (decreased) of serotonin transporter in bowel associated with serotonin and hyperplasia
2) Confidence 0.55 Published 2005 Journal Neurogastroenterol. Motil. Section Title Doc Link 16336502 Disease Relevance 0.93 Pain Relevance 0.30
Fluoxetine, a serotonin transporter (SERT) inhibitor, produced CPP in DD, but not control mice, suggesting that serotonin mediates cocaine CPP in DD mice.
Negative_regulation (inhibitor) of SERT associated with serotonin, cocaine and fluoxetine
3) Confidence 0.53 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18003826 Disease Relevance 0 Pain Relevance 1.11
CONCLUSIONS: The reduction in SERT density and anxiolytic-like effects with duloxetine, fluoxetine and, potentially, paroxetine suggest that down-regulation of the SERT may be a relevant mechanism in therapeutic response to these antidepressants.


Negative_regulation (regulation) of SERT
4) Confidence 0.51 Published 2007 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 17335951 Disease Relevance 0 Pain Relevance 0
Together, these results suggest that a low estrogen state increases SERT activity in the hippocampus despite an apparent reduction in SERT density.
Negative_regulation (reduction) of SERT in hippocampus associated with hippocampus
5) Confidence 0.51 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298349 Disease Relevance 0.31 Pain Relevance 0.70
Inhibition of the serotonin transporter (5-HTT) is a principal initial target of many antidepressants.
Negative_regulation (Inhibition) of 5-HTT associated with antidepressant and serotonin
6) Confidence 0.51 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12464448 Disease Relevance 0.06 Pain Relevance 0.21
Sert mRNA levels were highly reduced in the VT retina of Zic2kd/kd embryos compared with WT littermates (Figure 3A).
Negative_regulation (reduced) of Sert in embryos
7) Confidence 0.50 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
This demonstrates that inhibition of Sert does not affect the refinement of cRGCs.
Negative_regulation (inhibition) of Sert
8) Confidence 0.50 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.13 Pain Relevance 0.26
Nevertheless, the partial rescue of the Zic2 missexpression phenotype by blocking Sert demonstrates clearly that Zic2 upregulates Sert, which then inhibits the proper refinement and arborization of retinal axons at the colliculus.
Negative_regulation (blocking) of Sert
9) Confidence 0.50 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.35
Additionally, fluoxetine, a serotonin transporter (SERT) inhibitor, also had no effect on these parameters.
Negative_regulation (inhibitor) of SERT associated with serotonin and fluoxetine
10) Confidence 0.49 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12006604 Disease Relevance 0.15 Pain Relevance 1.20
Thus infection induced inflammation increases EC numbers, as has been reported in PI-IBS, and reduces SERT.
Negative_regulation (reduces) of SERT associated with inflammation and infection
11) Confidence 0.48 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16336502 Disease Relevance 1.04 Pain Relevance 0.28
Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse.
Negative_regulation (inhibition) of serotonin transporter associated with serotonin
12) Confidence 0.43 Published 2006 Journal Neurogastroenterol. Motil. Section Title Doc Link 16700726 Disease Relevance 0.43 Pain Relevance 0.41
These results demonstrate that reduced SERT function (via pharmacological blockade) significantly alters GI motility and sensitivity in mice, and support the concept that altered SERT expression and function could contribute to symptoms associated with IBS and IBD.
Negative_regulation (reduced) of SERT associated with inflammatory bowel disease and spastic colon
13) Confidence 0.43 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16700726 Disease Relevance 0.46 Pain Relevance 0.40
RESULTS: Duloxetine and fluoxetine both reduced SERT density in cortex and induced anxiolytic-like effects.
Negative_regulation (reduced) of SERT in cortex
14) Confidence 0.43 Published 2007 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 17335951 Disease Relevance 0 Pain Relevance 0
The only two downregulated genes in the list were the neural precursor cell-expressed, developmentally downregulated gene 9 (Nedd9/HEF1) and the serotonin transporter (Sert; encoded by slc6a4).
Negative_regulation (downregulated) of serotonin transporter in precursor cell associated with serotonin
15) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.09 Pain Relevance 0.12
Mucosal SERT and tryptophan hydroxylase-1 expression are decreased in experimental inflammation, IBS-C, IBS-D, and ulcerative colitis.
Negative_regulation (decreased) of SERT associated with inflammatory bowel disease and inflammation
16) Confidence 0.41 Published 2005 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 15798484 Disease Relevance 1.02 Pain Relevance 0.43
Cocaine inhibition of SERT and/or NET in the absence of DAT inhibition in DAT-CI mice leads to locomotor suppression.
Negative_regulation (inhibition) of SERT associated with cocaine
17) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.67
It is not clear whether cocaine inhibition of SERT or NET enhances or dampens locomotor stimulation in wild type mice where DAT is also inhibited.
Spec (whether) Negative_regulation (inhibition) of SERT associated with cocaine
18) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.61
To examine whether these transporters are involved in MPTP-induced neuroblast apoptosis in the SVZ, terminal deoxynucleotidyl transferase-mediated dUTP endlabeling (TUNEL)-positive cells were semiquantitatively analyzed after the injection of GBR12909 (GBR), a DAT inhibitor; tetrabenazine (TBZ), a VMAT2 inhibitor; fluoxetine (FLU), a SERT inhibitor, or desipramine (DES), a NET inhibitor, prior to MPTP injection.
Negative_regulation (inhibitor) of SERT in neuroblast associated with parkinson's disease, desipramine, apoptosis and fluoxetine
19) Confidence 0.39 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19616025 Disease Relevance 1.39 Pain Relevance 0.44
This is in line with previous studies reporting declines in operant responding for drugs and intracranial self-stimulation with fluoxetine treatment, suggesting that the effect of SERT blockade can be generalized to different reward types.
Negative_regulation (blockade) of SERT associated with fluoxetine
20) Confidence 0.38 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17356573 Disease Relevance 0 Pain Relevance 0.44

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