INT74727

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Context Info
Confidence 0.00
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
striatum 1
cortex 1
Slc6a4 (Mus musculus)
Hpic1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 14 100.00 Very High Very High Very High
Dopamine 10 100.00 Very High Very High Very High
Neurotransmitter 4 75.00 Quite High
gABA 2 25.00 Low Low
fluoxetine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 2 92.52 High High
Dyskinesias 4 75.00 Quite High
Drug Induced Neurotoxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In synaptosome preparations from mouse striatum and cortex, the HP metabolites haloperidol pyridinium (HPP+), reduced haloperidol pyridinium (RHPP+), and haloperidol tetrahydropyridine (HPTP) inhibited the presynaptic uptake of dopamine and serotonin, with greater affinity for the serotonin transporter.
serotonin transporter Binding (affinity) of haloperidol tetrahydropyridine in cortex associated with dopamine and serotonin
1) Confidence 0.00 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555021 Disease Relevance 0.24 Pain Relevance 0.34
In synaptosome preparations from mouse striatum and cortex, the HP metabolites haloperidol pyridinium (HPP+), reduced haloperidol pyridinium (RHPP+), and haloperidol tetrahydropyridine (HPTP) inhibited the presynaptic uptake of dopamine and serotonin, with greater affinity for the serotonin transporter.
serotonin transporter Binding (affinity) of haloperidol tetrahydropyridine in striatum associated with dopamine and serotonin
2) Confidence 0.00 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555021 Disease Relevance 0.24 Pain Relevance 0.34

General Comments

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