INT7474

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 3.31
Pain Relevance 18.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
nerve 2
tail 2
nucleus 1
THAL 1
ear 1
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 84 100.00 Very High Very High Very High
antagonist 77 100.00 Very High Very High Very High
Clonidine 74 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
monoamine 6 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
intrathecal 3 99.98 Very High Very High Very High
Somatostatin 3 99.78 Very High Very High Very High
antinociception 3 99.72 Very High Very High Very High
noradrenaline 20 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 5 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.84 Very High Very High Very High
Neuropathic Pain 6 97.64 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 5 96.28 Very High Very High Very High
Nervous System Injury 2 96.20 Very High Very High Very High
Muscle Rigidity 8 92.40 High High
Schizophrenia 2 91.32 High High
Convulsion 3 88.04 High High
Shock 2 87.48 High High
Aids-related Complex 1 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an attempt to evaluate the possible functional role of alpha-2 adrenoceptors located on noradrenergic nerve endings in the regulation of cerebral norepinephrine metabolism, we have measured the effects of clonidine and idazoxan on cerebral free 3,4-dihydroxyphenylethyleneglycol (DOPEG) levels (an index of norepinephrine turnover) in the rat after surgical and experimental manipulations that allow an exclusive interaction of the alpha-2 adrenergic agents with presynaptic alpha-2 autoreceptors.
Gene_expression (presynaptic) of alpha-2 in nerve associated with clonidine
1) Confidence 0.67 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027307 Disease Relevance 0 Pain Relevance 0.23
The prophylactic effects of clonidine were blocked by simultaneous infusion of idazoxan, an alpha-2 adrenergic antagonist, which suggests strongly that these effects were produced at an alpha-2 receptor.
Gene_expression (produced) of alpha-2 associated with antagonist and clonidine
2) Confidence 0.67 Published 1993 Journal Brain Res. Section Abstract Doc Link 7908598 Disease Relevance 0 Pain Relevance 0.71
The reverse was true in the rabbit ear vein. pA2 values for prazosin (rat tissues, 9.7-10; guinea-pig aorta, 9.1-9.3) and for yohimbine (rat tissues, 6.6-6.9; guinea-pig aorta, 6.2-6.3; rabbit ear vein, 7.9) suggested that alpha 1H (high affinity for prazosin)-, alpha 1L (lower affinity for prazosin)-, and alpha 2-adrenoceptors were predominantly distributed in the rat tissues, the guinea-pig aorta, and in the rabbit ear vein, respectively.
Gene_expression (distributed) of alpha 2 in ear
3) Confidence 0.66 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7589178 Disease Relevance 0.09 Pain Relevance 0.34
The present results demonstrate that alpha 2 autoreceptors are a major mechanism in the control of NA efflux in the BSTV.
Gene_expression (mechanism) of alpha 2 in BSTV associated with noradrenaline
4) Confidence 0.65 Published 1993 Journal Brain Res. Section Abstract Doc Link 8097660 Disease Relevance 0 Pain Relevance 0.76
Thus, these functional, anatomical and neurochemical correlates of the alpha 2 binding site distribution establish a neurological basis for the complex pharmacological effects of centrally acting alpha 2 agonists.
Gene_expression (distribution) of alpha 2 associated with agonist
5) Confidence 0.65 Published 1984 Journal Brain Res. Section Abstract Doc Link 6324960 Disease Relevance 0.07 Pain Relevance 0.55
The facilitation was selective for alpha-2 antagonists because neither the alpha-1 antagonist corynanthine (0.1-10.0 mg/kg i.p.), nor the beta antagonist propranolol (0.1-10.0 mg/kg i.p.), nor the selective beta-1 antagonist ICI 89,406 (10 micrograms/40 microliter i.c.v.) nor the beta-2 antagonist ICI 118,551 (0.5-5.0 mg/kg i.p.) modified kindling development.
Gene_expression (antagonists) of alpha-2 associated with antagonist
6) Confidence 0.64 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2885413 Disease Relevance 0.15 Pain Relevance 0.62
Lumbar intrathecal injection of alpha-2, but not alpha-1 or an opiate agonist, resulted in a dose-dependent reversal of the allodynia, with the ordering of activity (ED50 in micrograms in parentheses) being dexmedetomidine (0.9) > oxymetazoline (14) = guanfacine (17) = 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline (19) = 2-(2,6-diethylphenylamino)-2-imidazoline (21) = clonidine (22) > morphine (> 30) = methoxamine (> 30 micrograms).
Gene_expression (injection) of alpha-2 associated with allodynia, agonist, opiate, morphine, clonidine and intrathecal
7) Confidence 0.62 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815335 Disease Relevance 0.62 Pain Relevance 1.23
BACKGROUND: When administered intrathecally, alpha-2 adrenergic agonists produce spinally mediated antinociception, but also rapidly redistribute to supraspinal sites.
Gene_expression (produce) of alpha-2 associated with antinociception and agonist
8) Confidence 0.58 Published 2003 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12648203 Disease Relevance 0 Pain Relevance 0.15
The thick ascending limb (THAL) possesses both alpha-2 and beta-adrenergic receptors.
Gene_expression (possesses) of alpha-2 in THAL
9) Confidence 0.57 Published 2001 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 11507016 Disease Relevance 0 Pain Relevance 0.17
The presence of alpha-2 adrenoceptors which mediate vasoconstriction was demonstrated.
Gene_expression (presence) of alpha-2 associated with increased venous pressure under development
10) Confidence 0.57 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6094793 Disease Relevance 0.10 Pain Relevance 0.17
It is concluded that presynaptic alpha-2 adrenoceptors present on serotonergic nerve endings in the hypothalamus are not activated by endogenous NE and do not seem to play a physiological role in the regulation of serotonergic neurotransmission.
Gene_expression (present) of alpha-2 in nerve
11) Confidence 0.55 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6323679 Disease Relevance 0 Pain Relevance 0.43
However, presynaptic inhibitory alpha-2 adrenoceptors can be acted upon by exogenous agonists to inhibit 5-HT release.
Gene_expression (presynaptic) of alpha-2 associated with agonist
12) Confidence 0.48 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6323679 Disease Relevance 0 Pain Relevance 0.41
Synergism of alpha 1, alpha 2, and beta were required for full antinatriuresis.
Gene_expression (Synergism) of alpha 2
13) Confidence 0.45 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3028153 Disease Relevance 0.09 Pain Relevance 0.11
An alpha-1 antagonist reversed only rigidity, whereas, alpha-2 antagonists and beta-agonists were generally ineffective in all tests.
Gene_expression (ineffective) of alpha-2 associated with antagonist and agonist
14) Confidence 0.43 Published 1992 Journal J Pharmacol Toxicol Methods Section Abstract Doc Link 1349839 Disease Relevance 0.68 Pain Relevance 0.63
Thus, idazoxan and Wy 27127 were equipotent alpha 2-adrenoceptor antagonists in vitro, however, the alpha 2:alpha 1 selectivity of Wy 27127 was considerably greater than that of idazoxan by virtue of weaker alpha 1-adrenoceptor antagonism.
Gene_expression (antagonists) of alpha 2 associated with antagonist
15) Confidence 0.30 Published 1986 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2881217 Disease Relevance 0 Pain Relevance 0.38
The displacement of 3H-ligands to alpha-2, serotonin1 (5-HT1), dopamine, beta and opiate receptors is either absent or takes place at relatively higher concentrations.
Neg (absent) Gene_expression (absent) of alpha-2 associated with dopamine and opiate
16) Confidence 0.26 Published 1988 Journal Drugs Exp Clin Res Section Abstract Doc Link 2839325 Disease Relevance 0 Pain Relevance 0.15
Based on the potency ratio between alpha-1 and alpha-2 blocking activities, DHC or YO was most selective for alpha-1 or alpha-2 subtype, respectively, among the four YO analogs.
Gene_expression (selective) of alpha-2 associated with potency
17) Confidence 0.26 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1976443 Disease Relevance 0 Pain Relevance 0.38
The magnitude of these changes and particularly the rapidity of the alpha-2 changes suggest that clorgyline-induced alpha-2 autoreceptor changes may precede and contribute to the changes in postsynpatic alpha-1- and beta-receptors.
Gene_expression (precede) of alpha-2 autoreceptor
18) Confidence 0.26 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6123960 Disease Relevance 0 Pain Relevance 0.24
Greater than 77% of alpha 2 adrenoceptors in the locus ceruleus must be available for the hypnotic response to alpha 2 agonists to be expressed.
Gene_expression (expressed) of alpha 2
19) Confidence 0.24 Published 1995 Journal Anesthesiology Section Body Doc Link 7717568 Disease Relevance 0 Pain Relevance 0
The mixed alpha-1/alpha-2 adrenergic agonist clonidine and the highly specific alpha-2 adrenergic agonist UK-14304, both partially and dose-dependently produced flupirtine appropriate responding.
Gene_expression (produced) of alpha-2 associated with agonist and clonidine
20) Confidence 0.22 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2901483 Disease Relevance 0.09 Pain Relevance 1.18

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