INT74745

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 9.85
Pain Relevance 14.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm8) signal transducer activity (Grm8)
Anatomy Link Frequency
synapses 4
neurons 3
masseter 2
nucleus accumbens 1
cerebellar granule cells 1
Grm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 278 100.00 Very High Very High Very High
Glutamate 183 100.00 Very High Very High Very High
Glutamate receptor 80 100.00 Very High Very High Very High
withdrawal 17 99.84 Very High Very High Very High
depression 527 99.56 Very High Very High Very High
Morphine 18 99.34 Very High Very High Very High
central pain 10 99.34 Very High Very High Very High
projection neuron 1 99.32 Very High Very High Very High
Nucleus accumbens 26 98.40 Very High Very High Very High
Substantia nigra 10 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Frailty 25 99.72 Very High Very High Very High
Depression 527 99.56 Very High Very High Very High
Pain 112 99.34 Very High Very High Very High
Nociception 22 99.04 Very High Very High Very High
Brain Injury 150 95.92 Very High Very High Very High
Hypersensitivity 12 91.88 High High
Hyperalgesia 6 90.56 High High
Injury 60 90.16 High High
Contusions 4 89.88 High High
Arthritis 76 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, our Western blot analyses revealed that mGluR 5 protein, but not mGluR 1 protein, is reliably detected in trigeminal ganglia and the masseter nerve.
Neg (not) Gene_expression (detected) of mGluR in masseter
1) Confidence 0.68 Published 2007 Journal Neuroscience Section Abstract Doc Link 17306466 Disease Relevance 0.46 Pain Relevance 0.31
First, our Western blot analyses revealed that mGluR 5 protein, but not mGluR 1 protein, is reliably detected in trigeminal ganglia and the masseter nerve.
Neg (not) Gene_expression (detected) of mGluR in masseter
2) Confidence 0.68 Published 2007 Journal Neuroscience Section Abstract Doc Link 17306466 Disease Relevance 0.46 Pain Relevance 0.31
Such nigral mGluR activation may produce opposite effects upon basal and NMDA-evoked release of DA in the SN.
Gene_expression (produce) of mGluR associated with substantia nigra
3) Confidence 0.59 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11960611 Disease Relevance 0 Pain Relevance 0.51
These results demonstrate that treatment with agonists to group II and III mGluRs following SCI affects mechanical responses, exploratory behavior, and mGluR2/3 expression without affecting the amount of tissue spared, suggesting that the level of mGluR expression after SCI may modulate nociceptive responses.
Gene_expression (expression) of mGluR associated with nociception, frailty and agonist
4) Confidence 0.59 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 11771948 Disease Relevance 1.00 Pain Relevance 0.38
Additionally, the differential distribution of distinct mGluR subtypes mRNA in particular thalamic nuclei of normal rats suggests that they could be involved in the processing of somatosensory information.
Gene_expression (distribution) of mGluR
5) Confidence 0.57 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.14 Pain Relevance 0.30
Evoked and spontaneous behavioral measures of CCP, locomotor recovery, changes in mGluR expression, and amount of spared tissue were examined.
Gene_expression (expression) of mGluR associated with central pain
6) Confidence 0.52 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 11771948 Disease Relevance 1.25 Pain Relevance 0.81
We suggested that the damaged neurons utilize a self-protection first mechanism [17], because mGluR expression shows a characteristic time sequence (the damaged neurons begin to express protective group III mGluRs to protect themselves at first, and then express the neuro-harmful group I mGluRs), and the activation of group II and III mGluRs has been reported to be neuroprotective both in vitro and in vivo [35-37].
Gene_expression (expression) of mGluR in neurons
7) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.81 Pain Relevance 0.19
To begin evaluating mGluRs in SCI, we quantified the changes in mGluR expression after SCI in control (naive), sham, and impact injured adult male Sprague-Dawley rats (200-250 g).
Gene_expression (expression) of mGluR associated with frailty
8) Confidence 0.44 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11476590 Disease Relevance 0.74 Pain Relevance 0.42
Metabotropic glutamate receptors (mGluR) are coupled to multiple intracellular second messenger systems through G-proteins and densely expressed by medium spiny projection neurons in the rat striatum.
Gene_expression (expressed) of mGluR in striatum associated with glutamate receptor and projection neuron
9) Confidence 0.42 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555048 Disease Relevance 0 Pain Relevance 0.33
However, the expression of group II mGluR decreased when the expression of group I and III mGluRs increased in our study.
Gene_expression (expression) of mGluR
10) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.68 Pain Relevance 0.12
To confirm group I mGluR expression in cultured neurons, both in situ hybridization and immunocytochemistry were performed, which detected moderate levels of mGluR1 and mGluR5 mRNAs and protein products in most neurons (>70%), respectively.
Gene_expression (expression) of mGluR in neurons
11) Confidence 0.36 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11165379 Disease Relevance 0 Pain Relevance 0.26
We have shown that activation of a group III mGluR depresses eEPSC amplitude concurrently with an increase in sEPSC frequency (Evans et al., 2000a, 2001), suggesting that AP-dependent and independent glutamate release may be differentially modulated by this receptor in layer V of the EC.
Gene_expression (depresses) of mGluR associated with glutamate
12) Confidence 0.33 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0 Pain Relevance 0.14
A selective group II mGluR antagonist (EGLU, 10 ?
Gene_expression (antagonist) of mGluR associated with antagonist
13) Confidence 0.32 Published 2006 Journal Mol Pain Section Body Doc Link PMC1471776 Disease Relevance 0.58 Pain Relevance 0.68
A selective group II mGluR antagonist (EGLU) reverses the effects of LY354740
Gene_expression (antagonist) of mGluR associated with antagonist
14) Confidence 0.32 Published 2006 Journal Mol Pain Section Body Doc Link PMC1471776 Disease Relevance 0.59 Pain Relevance 0.71
This potentiation occurred through insertion of the higher conducting GluR2-lacking AMPAR into both synaptic pathways, which subsequently permitted expression of metabotropic glutamate receptor (mGluR)-dependent LTD through reinsertion of the lower conducting GluR2-containing AMPAR at these synapses [16].
Gene_expression (expression) of mGluR in synapses associated with depression and glutamate receptor
15) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.25 Pain Relevance 1.02
Calcium current inhibition in cells expressing the group I mGluR, mGluR5b was 29 ± 2% (figure 6; n = 21), similar to that through other group I mGluRs tested (see figure 2).
Gene_expression (expressing) of mGluR
16) Confidence 0.31 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
The latter hypothesis predicts a reduction in mGluR cell surface expression or perhaps a change in surface distribution in the presence of Siah1a, such as occurs in the presence of Homer proteins [24,44,45].
Gene_expression (expression) of mGluR
17) Confidence 0.31 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
Effect of Siah1a on mGluR surface expression and localization
Gene_expression (expression) of mGluR
18) Confidence 0.31 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.07
9-tetrahydrocannabinol (THC), induced GluR2-lacking AMPAR insertion into the PPN Glu-DA synapses without significant effects on the local Glu-DA synapses, thus permitting subsequent expression of mGluR-dependent LTD through GluR2-containing AMPAR reinsertion at the PPN Glu-DA synapses [16].
Gene_expression (expression) of mGluR in synapses associated with depression
19) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.31 Pain Relevance 0.96
-ethyl-4-carboxyphenylglycine (CPPG, 10 µM) and II/III mGluR antagonist (RS)-?
Gene_expression (antagonist) of mGluR associated with antagonist
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.81 Pain Relevance 1.00

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