INT74777

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Context Info
Confidence 0.50
First Reported 1998
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.70
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
nasal 2
endothelial cells 1
bladder 1
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 98.36 Very High Very High Very High
Inflammatory mediators 1 87.76 High High
Inflammation 6 83.68 Quite High
interstitial cystitis 1 81.16 Quite High
cva 3 75.32 Quite High
cytokine 9 75.00 Quite High
Pain 2 71.96 Quite High
local anesthetic 1 55.28 Quite High
ischemia 1 46.28 Quite Low
Inflammatory marker 1 36.08 Quite Low
Disease Link Frequency Relevance Heat
Anaphylaxis 212 99.32 Very High Very High Very High
Angina 8 98.36 Very High Very High Very High
Emergencies 16 97.84 Very High Very High Very High
Atherosclerosis 1 93.52 High High
Rupture 1 88.96 High High
Urticaria 12 88.24 High High
INFLAMMATION 4 87.76 High High
Interstitial Cystitis 1 81.16 Quite High
Cv General 3 Under Development 1 75.32 Quite High
Hypersensitivity 22 72.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Tryptase levels are elevated during spontaneous ischemic episodes in unstable angina but not after the ergonovine test in variant angina].
Positive_regulation (elevated) of Gene_expression (levels) of Tryptase associated with angina
1) Confidence 0.50 Published 1998 Journal Cardiologia Section Title Doc Link 9557375 Disease Relevance 0.84 Pain Relevance 0.62
Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.
Positive_regulation (stimulated) of in endothelial cells Gene_expression (production) of tryptase in bladder
2) Confidence 0.24 Published 2006 Journal J. Urol. Section Title Doc Link 16952710 Disease Relevance 0.25 Pain Relevance 0.17
In an emergency department study, elevated histamine levels were observed in 42 of 97 patients, but only 20 also exhibited increased tryptase levels [30].
Positive_regulation (increased) of Gene_expression (levels) of tryptase associated with emergencies
3) Confidence 0.16 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.03 Pain Relevance 0
However, tryptase levels may not be elevated in all forms of anaphylaxis (eg, it is frequently normal in foodassociated anaphylaxis) [18,30].
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of tryptase associated with anaphylaxis
4) Confidence 0.16 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.36 Pain Relevance 0
Furthermore, increased levels of eosinophil cationic protein (ECP) and albumin, but not tryptase, in nasal lavage from workers exposed to UV coatings have been observed.
Positive_regulation (increased) of Gene_expression (levels) of tryptase in nasal
5) Confidence 0.12 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.21 Pain Relevance 0.13

General Comments

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