INT7479

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1980
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.71
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ggh) extracellular space (Ggh) extracellular region (Ggh)
lysosome (Ggh)
Anatomy Link Frequency
pituitary 2
plasma 1
blood 1
DIA 1
sensory nerves 1
Ggh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 2 99.84 Very High Very High Very High
Analgesic 8 99.82 Very High Very High Very High
Clonidine 24 99.80 Very High Very High Very High
dexamethasone 5 99.56 Very High Very High Very High
anesthesia 4 97.72 Very High Very High Very High
ketamine 2 97.56 Very High Very High Very High
Inflammation 10 97.52 Very High Very High Very High
substantia gelatinosa 1 96.44 Very High Very High Very High
qutenza 4 95.52 Very High Very High Very High
Somatostatin 9 94.88 High High
Disease Link Frequency Relevance Heat
Hypertension 11 100.00 Very High Very High Very High
Sprains And Strains 7 99.48 Very High Very High Very High
Obesity 42 99.10 Very High Very High Very High
INFLAMMATION 9 97.52 Very High Very High Very High
Sleep Disorders 2 92.52 High High
Pain 2 84.08 Quite High
Cv Unclassified Under Development 6 82.56 Quite High
Hypotension 1 79.68 Quite High
Pressure And Volume Under Development 1 79.16 Quite High
Insulin Resistance 3 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of the H-channel conductance (GH) ranged between -55 and -120 mV.
Positive_regulation (activation) of GH
1) Confidence 0.62 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 7535916 Disease Relevance 0 Pain Relevance 0.12
lean but not in obese rats (pretreated or not with hexarelin); lean rats chronically treated with hexarelin showed a greater increase in plasma GH as compared with control counterparts.
Positive_regulation (increase) of GH in plasma associated with obesity
2) Confidence 0.54 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 1.31 Pain Relevance 0.09
Analysis of variance, considering only those data from mystacial VIB, GH, and HS fibers, indicated significant differences for all of the following measures: number of collaterals, number of boutons per collateral, arbor area, arbor circumference, and arbor circularity (form factor).
Positive_regulation (mystacial) of GH in boutons
3) Confidence 0.50 Published 1988 Journal J. Comp. Neurol. Section Abstract Doc Link 3343389 Disease Relevance 0.11 Pain Relevance 0.11
These studies demonstrate that in another strain of hypertensive rat, the GH rat, alpha 2-adrenoceptor density is increased as compared to the normotensive control at 12 but not 4 weeks of age.
Positive_regulation (increased) of GH associated with hypertension and sprains and strains
4) Confidence 0.49 Published 1992 Journal J Auton Pharmacol Section Abstract Doc Link 1349889 Disease Relevance 0.84 Pain Relevance 0.35
At the end of the experiment, pituitary GH mRNA levels were significantly reduced in obese rats and hexarelin administration failed to increase pituitary GH mRNA and IGF-I concentrations in plasma and heart.
Neg (failed) Positive_regulation (increase) of GH in pituitary associated with obesity
5) Confidence 0.47 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 1.24 Pain Relevance 0.09
At caudal stimulation sites the tachypnea was accompanied by tonic DIA activity and cessation of GH.
Positive_regulation (cessation) of GH in DIA
6) Confidence 0.44 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 19135182 Disease Relevance 0.26 Pain Relevance 0.33
These findings are compatible with clonidine leading to stimulation of GH by inducing endogenous GHRH release.
Positive_regulation (stimulation) of GH associated with clonidine
7) Confidence 0.39 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 1.08
The heart-protective activity afforded by the peptide was divorced from any stimulation of the GH axis and is probably exerted through activation of specific cardiac receptors.
Positive_regulation (stimulation) of GH in heart
8) Confidence 0.36 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 0.59 Pain Relevance 0.03
The airways of the genetically hypertensive rat (GH) are hyperinnervated by substance P-containing sensory nerves and exhibit reduced inflammatory responsiveness to substance P and to capsaicin.
Positive_regulation (hyperinnervated) of GH in sensory nerves associated with qutenza, inflammation, hypertension and substance p
9) Confidence 0.29 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915843 Disease Relevance 0.64 Pain Relevance 0.61
Administration of clonidine markedly increased the GH responsiveness to GRF in rats anesthetized with urethane or ketamine.
Positive_regulation (increased) of GH associated with ketamine and clonidine
10) Confidence 0.29 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102470 Disease Relevance 0 Pain Relevance 0.56
The action on pituitary cells was restricted to those molecules as no changes occurred in LH, FSH, GH, TSH and PRL levels, after otherwise identical experimental conditions.
Neg (no) Positive_regulation (occurred) of GH in pituitary
11) Confidence 0.18 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2820173 Disease Relevance 0.72 Pain Relevance 0.33
In DEX-treated animals, the GH response to GHRH was partially blunted (5-min peak values, 270 +/- 50 ng/ml in saline-treated vs. 160 +/- 10 ng/ml in DEX-treated, P < 0.05); however, the simultaneous administration of BIM-23627 (0.2 mg/kg, iv) restored higher amplitude GH pulse, leading to a significantly higher overall mean GH response (area under the curve, 4200 +/- 120 ng/ml/30 min vs. 2800 +/- 100 ng/ml/30 min after GHRH alone; P < 0.05).
Positive_regulation (response) of GH associated with dexamethasone
12) Confidence 0.17 Published 2002 Journal Endocrinology Section Abstract Doc Link 11897676 Disease Relevance 0 Pain Relevance 0.80
Acute administration of narcotic analgesics to rats increases the blood levels of ACTH, GH and prolactin, and decreases levels of LH and TSH, however, there is no general consensus regarding changes in serum FSH, ADH and oxytocin as induced by narcotics in rats.
Positive_regulation (increases) of GH in blood associated with analgesic
13) Confidence 0.10 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6110621 Disease Relevance 0 Pain Relevance 0.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox