INT748

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.56
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
macrophages 1
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 5 99.60 Very High Very High Very High
spinal inflammation 24 99.08 Very High Very High Very High
Arthritis 6 97.60 Very High Very High Very High
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 99.86 Very High Very High Very High
Low Back Pain 29 99.60 Very High Very High Very High
Disease 11 99.52 Very High Very High Very High
Rheumatic Diseases 1 97.88 Very High Very High Very High
Seronegative Spondarthritis 2 97.60 Very High Very High Very High
Necrosis 2 86.76 High High
Cancer 2 86.40 High High
Genetic Predisposition To Disease 1 44.24 Quite Low
Arthritis 4 36.64 Quite Low
Infection 1 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, in macrophages from HLA-B27-expressing disease-prone transgenic rats, HLA-B27 dimer-like structures are readily detected after stimulation with interferon (IFN)-?
Transcription (detected) of HLA-B27 in macrophages associated with targeted disruption and disease
1) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.28 Pain Relevance 0.08
Antigen HLA-B27 was found in 276 of these 652 patients attending the ward for rheumatic diseases (42.4 per cent) and in 37 of the 302 unrelated persons in the control group (12.2 per cent).
Transcription (found) of HLA-B27 associated with rheumatic diseases
2) Confidence 0.63 Published 1979 Journal Acta Orthop Scand Section Abstract Doc Link 91304 Disease Relevance 0.52 Pain Relevance 0.49
CONCLUSION: The expression of mRNA of HLA-B27 determined with quantitative RT-PCR correlated with clinical disease activity in patients with AS.


Spec (determined) Transcription (expression) of HLA-B27
3) Confidence 0.52 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16755659 Disease Relevance 0 Pain Relevance 0
The HLA-B alleles were detected by PCR-SSP technique and the TNF-alpha polymorphism by PCR-RFLP.
Transcription (detected) of HLA-B
4) Confidence 0.52 Published 2006 Journal Hum. Immunol. Section Abstract Doc Link 17055360 Disease Relevance 0.52 Pain Relevance 0.14
From a longitudinal case analysis, data on quantitative measurement of HLA-B27 mRNA was shown to be valuable for patient's management.
Transcription (measurement) of HLA-B27
5) Confidence 0.39 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16755659 Disease Relevance 0 Pain Relevance 0
Quantitative measurement of HLA-B27 mRNA in patients with ankylosing spondylitis-- correlation with clinical activity.
Transcription (measurement) of HLA-B27 associated with spinal inflammation
6) Confidence 0.39 Published 2006 Journal J. Rheumatol. Section Title Doc Link 16755659 Disease Relevance 0.10 Pain Relevance 0.19
For further validation of the significance of increased HLA-B27 mRNA expression in AS patients, extended experiments were conducted in another 10 patients with definite AS possessing HLA-B27/B60 (B*40012).
Transcription (expression) of HLA-B27
7) Confidence 0.39 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16755659 Disease Relevance 0.15 Pain Relevance 0

General Comments

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