INT74812

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 10.10
Pain Relevance 9.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
skin 4
spinal 2
spinal cord 2
nerve 2
DRG 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 39 100.00 Very High Very High Very High
Spinal cord 17 100.00 Very High Very High Very High
COX2 16 100.00 Very High Very High Very High
aspirin 9 100.00 Very High Very High Very High
cOX1 7 100.00 Very High Very High Very High
cINOD 23 99.98 Very High Very High Very High
dexamethasone 6 99.86 Very High Very High Very High
dorsal root ganglion 19 99.84 Very High Very High Very High
electroacupuncture 9 99.64 Very High Very High Very High
Hyperalgesia 19 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 44 100.00 Very High Very High Very High
Diabetes Mellitus 9 99.86 Very High Very High Very High
Ganglion Cysts 19 99.84 Very High Very High Very High
Hyperalgesia 21 99.62 Very High Very High Very High
Necrosis 1 98.72 Very High Very High Very High
Cancer 11 98.54 Very High Very High Very High
Pain 8 97.64 Very High Very High Very High
Disease 6 97.64 Very High Very High Very High
Injury 5 97.20 Very High Very High Very High
Nociception 5 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the induction of COX-2 mRNA was inhibited by 2 Hz EA at various intensities, there was no significant change.
Negative_regulation (inhibited) of Positive_regulation (induction) of COX associated with electroacupuncture
1) Confidence 0.34 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942684 Disease Relevance 0.73 Pain Relevance 0.79
Vitamin D3 and tamoxifen, however, not only stimulate the release of AA from cells: they amplify rather than inhibits induced COX activity.
Negative_regulation (inhibits) of Positive_regulation (induced) of COX
2) Confidence 0.33 Published 2003 Journal FASEB J. Section Abstract Doc Link 12724337 Disease Relevance 0.48 Pain Relevance 0.21
Non-steroidal anti-inflammatory drugs inhibit constitutive (COX-1) and induced cyclooxygenase (COX-2), blocking prostaglandin production.
Negative_regulation (inhibit) of Positive_regulation (induced) of COX associated with inflammation and cinod
3) Confidence 0.27 Published 1998 Journal Neuroreport Section Abstract Doc Link 9559932 Disease Relevance 0.27 Pain Relevance 0.29
Non-steroidal anti-inflammatory drugs inhibit constitutive (COX-1) and induced cyclooxygenase (COX-2), blocking prostaglandin production.
Negative_regulation (blocking) of Positive_regulation (induced) of COX associated with inflammation and cinod
4) Confidence 0.27 Published 1998 Journal Neuroreport Section Abstract Doc Link 9559932 Disease Relevance 0.27 Pain Relevance 0.29
This increase in COX-2 mRNA concentration in the spinal cord on the opposite side of the inflammatory insult was abolished by resveratrol.
Negative_regulation (abolished) of Positive_regulation (increase) of COX in spinal cord associated with inflammation and spinal cord
5) Confidence 0.25 Published 2008 Journal Pain Section Abstract Doc Link 18814970 Disease Relevance 1.05 Pain Relevance 0.90
Celecoxib reduced the elevated PGE(2) levels in brain of kainate-treated rats and inhibited induced COX activity, demonstrating the ability of this compound to act on COX-2 in CNS.
Negative_regulation (inhibited) of Positive_regulation (induced) of COX in CNS associated with central nervous system
6) Confidence 0.23 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.26 Pain Relevance 0.45
The changes in our view of the importance of NSAID-induced cyclo-oxygenase (COX) inhibition on the pathogenesis and prevention of NSAID-induced gastrointestinal injury is presented.
Negative_regulation (inhibition) of Positive_regulation (induced) of COX associated with injury and cinod
7) Confidence 0.20 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17132203 Disease Relevance 0.36 Pain Relevance 0.69
After afferent nerve denervation, however, COX-2 inhibitors or dexamethasone which suppresses the acid-induced up-regulation of COX-2 are highly ulcerogenic.
Negative_regulation (suppresses) of Positive_regulation (up-regulation) of COX in nerve associated with cox-2 inhibitor and dexamethasone
8) Confidence 0.19 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787758 Disease Relevance 0.17 Pain Relevance 0.25
In conclusion, the antinociceptive effect exhibited by resveratrol was related to the prevention of COX-2 mRNA increase induced by carrageenan.
Negative_regulation (prevention) of Positive_regulation (increase) of COX associated with antinociceptive
9) Confidence 0.19 Published 2008 Journal Pain Section Abstract Doc Link 18814970 Disease Relevance 0.95 Pain Relevance 0.88
Resveratrol induced a prolonged antinociceptive effect, which was correlated to the inhibition of COX-2 mRNA increase in DRG and cord elicited by carrageenan.
Negative_regulation (inhibition) of Positive_regulation (increase) of COX in DRG associated with dorsal root ganglion and antinociceptive
10) Confidence 0.19 Published 2008 Journal Pain Section Abstract Doc Link 18814970 Disease Relevance 1.11 Pain Relevance 0.70
We examined whether inhibition of the proinflammatory cytokines, tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1), or selective blockade of cyclooxygenase-2 (COX-2), the COX isoform induced during inflammation, would accelerate postoperative small bowel transit in our model.
Spec (whether) Negative_regulation (blockade) of Positive_regulation (induced) of COX in bowel associated with necrosis, inflammation, cancer and cytokine
11) Confidence 0.16 Published 1999 Journal J. Surg. Res. Section Abstract Doc Link 10452868 Disease Relevance 0.55 Pain Relevance 0.34
Chronic treatment with insulin or ICI222155, an aldose reductase inhibitor (ARI) previously shown to prevent spinal polyol accumulation and formalin-evoked hyperalgesia in diabetic rats, prevented elevated spinal COX-2 protein and activity in diabetic rats.
Negative_regulation (prevented) of Positive_regulation (elevated) of COX in spinal associated with hyperalgesia and diabetes mellitus
12) Confidence 0.15 Published 2007 Journal Diabetes Section Abstract Doc Link 17287466 Disease Relevance 1.22 Pain Relevance 0.76
The up-regulation of COX-2 in the skin was also observed 3 and 6 h after carrageenan and was completely suppressed in the rats treated with N-monomethyl-L-arginine acetate.
Negative_regulation (suppressed) of Positive_regulation (up-regulation) of COX in skin
13) Confidence 0.11 Published 2004 Journal Anesthesiology Section Body Doc Link 15448533 Disease Relevance 0 Pain Relevance 0
The up-regulation of COX-1 in the skin was observed 3 and 6 h after carrageenan and was not suppressed in the rats treated with N-monomethyl-L-arginine acetate.
Neg (not) Negative_regulation (suppressed) of Positive_regulation (up-regulation) of COX in skin
14) Confidence 0.11 Published 2004 Journal Anesthesiology Section Body Doc Link 15448533 Disease Relevance 0.05 Pain Relevance 0
This link may have been broken by drugs that selectively inhibit the inducible COX-2 enzyme.
Negative_regulation (inhibit) of Positive_regulation (inducible) of COX
15) Confidence 0.10 Published 1999 Journal Lancet Section Abstract Doc Link 9929039 Disease Relevance 0.36 Pain Relevance 0.83
Furthermore, a 1-h incubation with IL-1beta markedly increased the inducible COX-2 mRNA level, which was inhibited by an IL-1r antagonist and dexamethasone, whereas IL-1beta showed no effect on the level of constitutive COX-1 mRNA.
Negative_regulation (inhibited) of Positive_regulation (inducible) of COX associated with antagonist and dexamethasone
16) Confidence 0.05 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.38 Pain Relevance 0.84
The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone.
Negative_regulation (inhibitors) of Positive_regulation (specific) of COX associated with aspirin, antagonist and dexamethasone
17) Confidence 0.05 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.40 Pain Relevance 0.84
Considering that the induction of COX 1 and COX2 are inhibited by ketoprofen, and that these enzymes are located in the stromal compartment of the CAM, we propose that its antiangiogenic effect may occur via inhibition of the two COX isoforms.
Negative_regulation (inhibited) of Positive_regulation (induction) of COX associated with cox2 and cox1
18) Confidence 0.02 Published 2003 Journal Biol. Res. Section Abstract Doc Link 14513718 Disease Relevance 0.24 Pain Relevance 0.19
The classic target of NSAIDs is the prevention of cyclooxygenase (COX) activation.
Negative_regulation (prevention) of Positive_regulation (activation) of COX associated with cinod
19) Confidence 0.02 Published 2006 Journal Ann. Neurol. Section Abstract Doc Link 16402383 Disease Relevance 0.93 Pain Relevance 0.45
The expression of the induced COX is inhibited by glucocorticoids which is not the case with the COX known up to then.
Negative_regulation (inhibited) of Positive_regulation (induced) of COX
20) Confidence 0.01 Published 2001 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 11571832 Disease Relevance 0.33 Pain Relevance 0.24

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