INT74814

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.69
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
neurons 3
neuropil 1
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 16 100.00 Very High Very High Very High
Antinociceptive 1 99.98 Very High Very High Very High
GABAergic 48 99.80 Very High Very High Very High
Pain 173 99.64 Very High Very High Very High
Analgesic 1 99.52 Very High Very High Very High
Glutamate 68 99.14 Very High Very High Very High
antagonist 88 98.82 Very High Very High Very High
Dorsal horn 5 94.72 High High
Spinal cord 12 94.24 High High
intrathecal 2 93.24 High High
Disease Link Frequency Relevance Heat
Pain 177 99.64 Very High Very High Very High
Nociception 19 95.28 Very High Very High Very High
Arthritis 147 92.60 High High
Neuropathic Pain 7 78.36 Quite High
Anxiety Disorder 12 66.60 Quite High
Hypersensitivity 1 53.80 Quite High
Injury 4 51.68 Quite High
Ganglion Cysts 8 46.72 Quite Low
Depression 6 45.72 Quite Low
Rheumatoid Arthritis 1 17.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between mGluR1 and GABAergic transmission further suggests that pain-related decrease of inhibitory transmission is an active process that involves activation of mGluR1.
mGluR1 Binding (interaction) of associated with pain and gabaergic
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.61 Pain Relevance 0.77
To isolate Ca influx through VGCCs, all glutamate-activated Ca sources were blocked using a combination of NMDAR, metabotropic glutamate receptor (mGluR), Ca-permeable AMPAR, and kainate receptor antagonists (CPP, MK801, MPEP, CPCCOEt, Joro spider toxin, NASPM, UBP302, respectively).
mGluR Binding (combination) of associated with glutamate, antagonist and glutamate receptor
2) Confidence 0.36 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2734993 Disease Relevance 0 Pain Relevance 0.38
The results obtained with highly selective antagonists for mGluR1 and mGluR5 [40,42,52,53] show that presynaptic mGluR1, but not postsynaptic mGluR5, can account for the pain-related changes of excitatory and inhibitory transmission in CeLC neurons.
mGluR1 Binding (account) of in neurons associated with pain and antagonist
3) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.62 Pain Relevance 0.82
mGluR1, but not mGluR5, can account for the pain-related changes of excitatory and inhibitory transmission in CeLC neurons
mGluR1 Binding (account) of in neurons associated with pain
4) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.70 Pain Relevance 0.78
In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats.
mGluR1 Binding (activity) of associated with analgesic and antinociceptive
5) Confidence 0.31 Published 1998 Journal Neuroreport Section Title Doc Link 9559947 Disease Relevance 0.75 Pain Relevance 1.02
Compelling anatomical and electrophysiological studies have indicated the presence of mGluR1 and mGluR5 in the neuropil of all the trigeminal nuclei [15].
mGluR1 Binding (presence) of in neuropil
6) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.32
All neurons except those injected with the mGluR1a-GFP or GFP-Siah1a-CT constructs, were co-injected with "enhanced" green fluorescent protein cDNA (0.005 ?
mGluR1a-GFP Neg (except) Binding (injected) of in neurons
7) Confidence 0.14 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

General Comments

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